CNBD2 — 100 ClinVar variants
All ClinVar germline CNBD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
8 Likely benign · 92 Uncertain significance
Full CNBD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNBD2 p.Ala121Thr Uncertain significance Single submitter
- CNBD2 p.Ala566Gly Uncertain significance Single submitter
- CNBD2 p.Ala566Thr Uncertain significance Single submitter
- CNBD2 p.Ala576Thr Uncertain significance Single submitter
- CNBD2 p.Ala88Thr Uncertain significance Single submitter
- CNBD2 p.Arg31Gln Uncertain significance Single submitter
- CNBD2 p.Arg3Lys Uncertain significance Single submitter
- CNBD2 p.Arg451Leu Uncertain significance Single submitter
- CNBD2 p.Arg544His Uncertain significance Single submitter
- CNBD2 p.Arg568Gln Uncertain significance Single submitter
- CNBD2 p.Arg69Leu Uncertain significance Single submitter
- CNBD2 p.Asn463Ser Uncertain significance Single submitter
- CNBD2 p.Asn475Ser Uncertain significance Single submitter
- CNBD2 p.Asp314Gly Uncertain significance Single submitter
- CNBD2 p.Cys392Arg Uncertain significance Single submitter
- CNBD2 p.Cys435Tyr Uncertain significance Single submitter
- CNBD2 p.Gln486Arg Uncertain significance Single submitter
- CNBD2 p.Gln67Glu Uncertain significance Single submitter
- CNBD2 p.Glu455Lys Uncertain significance Single submitter
- CNBD2 p.Gly39Val Uncertain significance Single submitter
- CNBD2 p.His177Gln Uncertain significance Single submitter
- CNBD2 p.His309Leu Uncertain significance Single submitter
- CNBD2 p.His56Asn Uncertain significance Single submitter
- CNBD2 p.Ile156Thr Uncertain significance Single submitter
- CNBD2 p.Ile313Arg Uncertain significance Single submitter
- CNBD2 p.Ile313Thr Uncertain significance Single submitter
- CNBD2 p.Ile395Thr Uncertain significance Single submitter
- CNBD2 p.Ile450Leu Uncertain significance Single submitter
- CNBD2 p.Ile468Leu Uncertain significance Single submitter
- CNBD2 p.Ile468Thr Uncertain significance Single submitter
- CNBD2 p.Ile524Val Uncertain significance Single submitter
- CNBD2 p.Leu12Phe Uncertain significance Single submitter
- CNBD2 p.Leu291Pro Uncertain significance Single submitter
- CNBD2 p.Leu322Pro Uncertain significance Single submitter
- CNBD2 p.Leu349Phe Uncertain significance Single submitter
- CNBD2 p.Leu534Ser Uncertain significance Single submitter
- CNBD2 p.Met281Ile Uncertain significance Single submitter
- CNBD2 p.Met328Leu Uncertain significance Single submitter
- CNBD2 p.Met394Thr Uncertain significance Single submitter
- CNBD2 p.Met394Val Uncertain significance Single submitter
- CNBD2 p.Met5Leu Uncertain significance Single submitter
- CNBD2 p.Met5Thr Uncertain significance Single submitter
- CNBD2 p.Phe363Cys Uncertain significance Single submitter
- CNBD2 p.Pro380Leu Uncertain significance Single submitter
- CNBD2 p.Pro431Leu Uncertain significance Single submitter
- CNBD2 p.Pro527Thr Uncertain significance Single submitter
- CNBD2 p.Pro551Thr Uncertain significance Single submitter
- CNBD2 p.Ser265Ala Uncertain significance Single submitter
- CNBD2 p.Ser389Leu Uncertain significance Single submitter
- CNBD2 p.Thr373Ala Uncertain significance Single submitter
- CNBD2 p.Thr74Ile Uncertain significance Single submitter
- CNBD2 p.Trp356Arg Uncertain significance Single submitter
- CNBD2 p.Tyr545Phe Uncertain significance Single submitter
- CNBD2 p.Val107Ile Uncertain significance Single submitter
- CNBD2 p.Val203Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CNBD2 p.Arg118Trp Uncertain significance Single submitter
- CNBD2 p.Arg133Cys Uncertain significance Single submitter
- CNBD2 p.Arg133His Uncertain significance Single submitter
- CNBD2 p.Arg139Cys Uncertain significance Single submitter
- CNBD2 p.Arg139His Uncertain significance Single submitter
- CNBD2 p.Arg141His Uncertain significance Single submitter
- CNBD2 p.Arg215Trp Uncertain significance Single submitter
- CNBD2 p.Arg234Trp Uncertain significance Single submitter
- CNBD2 p.Arg303His Likely benign Single submitter
- CNBD2 p.Arg518Trp Uncertain significance Single submitter
- CNBD2 p.Asp168Gly Uncertain significance Single submitter
- CNBD2 p.Asp175Val Uncertain significance Single submitter
- CNBD2 p.Asp295Glu Uncertain significance Single submitter
- CNBD2 p.Cys186Tyr Uncertain significance Single submitter
- CNBD2 p.Gln228His Uncertain significance Single submitter
- CNBD2 p.Glu167Lys Uncertain significance Single submitter
- CNBD2 p.Gly150Asp Uncertain significance Single submitter
- CNBD2 p.Gly42Glu Uncertain significance Single submitter
- CNBD2 p.Ile104Ser Uncertain significance Single submitter
- CNBD2 p.Ile89Ser Uncertain significance Single submitter
- CNBD2 p.Ile91Phe Uncertain significance Single submitter
- CNBD2 p.Lys413Asn Uncertain significance Single submitter
- CNBD2 p.Met205Thr Uncertain significance Single submitter
- CNBD2 p.Phe235Ser Uncertain significance Single submitter
- CNBD2 p.Phe457Ile Uncertain significance Single submitter
- CNBD2 p.Phe488Cys Uncertain significance Single submitter
- CNBD2 p.Pro178Leu Uncertain significance Single submitter
- CNBD2 p.Pro278His Uncertain significance Single submitter
- CNBD2 p.Pro508Ala Uncertain significance Single submitter
- CNBD2 p.Pro508Thr Uncertain significance Single submitter
- CNBD2 p.Pro556Thr Uncertain significance Single submitter
- CNBD2 p.Pro557Ala Uncertain significance Single submitter
- CNBD2 p.Pro557Thr Uncertain significance Single submitter
- CNBD2 p.Pro96Ala Uncertain significance Single submitter
- CNBD2 p.Pro96Thr Uncertain significance Single submitter
- CNBD2 p.Trp98Cys Uncertain significance Single submitter
- CNBD2 p.Val32Gly Uncertain significance Single submitter
- CNBD2 p.Val414Leu Uncertain significance Single submitter
All CNBD2 variants
Likely benign 8
- p.Ala121Ser Single submitter
- p.Ala23Thr Single submitter
- p.Arg303His Single submitter ⚠
- p.Arg518Gln Single submitter
- p.Met443Val Single submitter
- p.Pro380Ser Single submitter
- p.Tyr8His Single submitter
- p.Val412Met Single submitter
Uncertain significance 92
- p.Ala121Thr Single submitter ⚠
- p.Ala566Gly Single submitter ⚠
- p.Ala566Thr Single submitter ⚠
- p.Ala576Thr Single submitter ⚠
- p.Ala88Thr Single submitter ⚠
- p.Arg118Trp Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg234Trp Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg3Lys Single submitter ⚠
- p.Arg451Leu Single submitter ⚠
- p.Arg518Trp Single submitter ⚠
- p.Arg544His Single submitter ⚠
- p.Arg568Gln Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Asn463Ser Single submitter ⚠
- p.Asn475Ser Single submitter ⚠
- p.Asp168Gly Single submitter ⚠
- p.Asp175Val Single submitter ⚠
- p.Asp295Glu Single submitter ⚠
- p.Asp314Gly Single submitter ⚠
- p.Cys186Tyr Single submitter ⚠
- p.Cys392Arg Single submitter ⚠
- p.Cys435Tyr Single submitter ⚠
- p.Gln228His Single submitter ⚠
- p.Gln486Arg Single submitter ⚠
- p.Gln67Glu Single submitter ⚠
- p.Glu167Lys Single submitter ⚠
- p.Glu455Lys Single submitter ⚠
- p.Gly150Asp Single submitter ⚠
- p.Gly39Val Single submitter ⚠
- p.Gly42Glu Single submitter ⚠
- p.His177Gln Single submitter ⚠
- p.His309Leu Single submitter ⚠
- p.His56Asn Single submitter ⚠
- p.Ile104Ser Single submitter ⚠
- p.Ile156Thr Single submitter ⚠
- p.Ile313Arg Single submitter ⚠
- p.Ile313Thr Single submitter ⚠
- p.Ile395Thr Single submitter ⚠
- p.Ile450Leu Single submitter ⚠
- p.Ile468Leu Single submitter ⚠
- p.Ile468Thr Single submitter ⚠
- p.Ile524Val Single submitter ⚠
- p.Ile89Ser Single submitter ⚠
- p.Ile91Phe Single submitter ⚠
- p.Leu12Phe Single submitter ⚠
- p.Leu291Pro Single submitter ⚠
- p.Leu322Pro Single submitter ⚠
- p.Leu349Phe Single submitter ⚠
- p.Leu534Ser Single submitter ⚠
- p.Lys413Asn Single submitter ⚠
- p.Met205Thr Single submitter ⚠
- p.Met281Ile Single submitter ⚠
- p.Met328Leu Single submitter ⚠
- p.Met394Thr Single submitter ⚠
- p.Met394Val Single submitter ⚠
- p.Met5Leu Single submitter ⚠
- p.Met5Thr Single submitter ⚠
- p.Phe235Ser Single submitter ⚠
- p.Phe363Cys Single submitter ⚠
- p.Phe457Ile Single submitter ⚠
- p.Phe488Cys Single submitter ⚠
- p.Pro178Leu Single submitter ⚠
- p.Pro278His Single submitter ⚠
- p.Pro380Leu Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro508Ala Single submitter ⚠
- p.Pro508Thr Single submitter ⚠
- p.Pro527Thr Single submitter ⚠
- p.Pro551Thr Single submitter ⚠
- p.Pro556Thr Single submitter ⚠
- p.Pro557Ala Single submitter ⚠
- p.Pro557Thr Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Pro96Thr Single submitter ⚠
- p.Ser265Ala Single submitter ⚠
- p.Ser389Leu Single submitter ⚠
- p.Thr373Ala Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Trp356Arg Single submitter ⚠
- p.Trp98Cys Single submitter ⚠
- p.Tyr545Phe Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val32Gly Single submitter ⚠
- p.Val414Leu Single submitter ⚠