CNDP2 — 86 ClinVar variants
All ClinVar germline CNDP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Benign · 5 Likely benign · 79 Uncertain significance
Full CNDP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNDP2 p.Thr403Ala Uncertain significance Multiple submitters
- CNDP2 p.Ala23Ser Uncertain significance Single submitter
- CNDP2 p.Ala268Thr Uncertain significance Single submitter
- CNDP2 p.Ala2Val Uncertain significance Single submitter
- CNDP2 p.Ala322Thr Uncertain significance Single submitter
- CNDP2 p.Ala396Pro Uncertain significance Single submitter
- CNDP2 p.Ala3Thr Uncertain significance Single submitter
- CNDP2 p.Ala400Thr Uncertain significance Single submitter
- CNDP2 p.Arg211Gly Uncertain significance Single submitter
- CNDP2 p.Arg254Met Uncertain significance Single submitter
- CNDP2 p.Arg369Cys Uncertain significance Single submitter
- CNDP2 p.Arg84Met Uncertain significance Single submitter
- CNDP2 p.Asp101Asn Uncertain significance Single submitter
- CNDP2 p.Cys95Arg Uncertain significance Single submitter
- CNDP2 p.Glu166Lys Uncertain significance Single submitter
- CNDP2 p.Glu285Lys Uncertain significance Single submitter
- CNDP2 p.Glu355Lys Uncertain significance Single submitter
- CNDP2 p.Glu373Asp Uncertain significance Single submitter
- CNDP2 p.Gly209Ser Uncertain significance Single submitter
- CNDP2 p.Gly233Ala Uncertain significance Single submitter
- CNDP2 p.Gly234Ser Uncertain significance Single submitter
- CNDP2 p.Gly338Asp Uncertain significance Single submitter
- CNDP2 p.Gly382Arg Uncertain significance Single submitter
- CNDP2 p.Gly65Ala Uncertain significance Single submitter
- CNDP2 p.His317Arg Uncertain significance Single submitter
- CNDP2 p.Ile154Phe Uncertain significance Single submitter
- CNDP2 p.Ile28Val Uncertain significance Single submitter
- CNDP2 p.Ile319Val Uncertain significance Single submitter
- CNDP2 p.Ile80Val Uncertain significance Single submitter
- CNDP2 p.Ile96Val Uncertain significance Single submitter
- CNDP2 p.Leu144Met Uncertain significance Single submitter
- CNDP2 p.Leu316Arg Uncertain significance Single submitter
- CNDP2 p.Lys201Asn Uncertain significance Single submitter
- CNDP2 p.Lys275Arg Uncertain significance Single submitter
- CNDP2 p.Lys375Arg Uncertain significance Single submitter
- CNDP2 p.Phe340Tyr Uncertain significance Single submitter
- CNDP2 p.Pro115Ala Uncertain significance Single submitter
- CNDP2 p.Pro136Leu Uncertain significance Single submitter
- CNDP2 p.Pro155Ser Uncertain significance Single submitter
- CNDP2 p.Pro204Ala Uncertain significance Single submitter
- CNDP2 p.Pro346Leu Uncertain significance Single submitter
- CNDP2 p.Ser223Thr Uncertain significance Single submitter
- CNDP2 p.Ser30Ile Uncertain significance Single submitter
- CNDP2 p.Thr349Ala Uncertain significance Single submitter
- CNDP2 p.Thr362Asn Uncertain significance Single submitter
- CNDP2 p.Thr428Met Uncertain significance Single submitter
- CNDP2 p.Val266Leu Uncertain significance Single submitter
- CNDP2 p.Val345Met Uncertain significance Single submitter
- CNDP2 p.Val420Met Uncertain significance Single submitter
- CNDP2 p.Val94Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CNDP2 p.Pro35Leu Benign Multiple submitters
- CNDP2 p.Ala322Gly Uncertain significance Single submitter
- CNDP2 p.Ala33Val Uncertain significance Single submitter
- CNDP2 p.Ala440Val Uncertain significance Single submitter
- CNDP2 p.Asp112Gly Uncertain significance Single submitter
- CNDP2 p.Asp16Asn Uncertain significance Single submitter
- CNDP2 p.Asp174Gly Uncertain significance Single submitter
- CNDP2 p.Glu271Gly Uncertain significance Single submitter
- CNDP2 p.Glu320Gln Uncertain significance Single submitter
- CNDP2 p.Gly139Ser Uncertain significance Single submitter
- CNDP2 p.Gly151Val Uncertain significance Single submitter
- CNDP2 p.Gly261Ser Uncertain significance Single submitter
- CNDP2 p.Gly379Ser Uncertain significance Single submitter
- CNDP2 p.Ile11Met Uncertain significance Single submitter
- CNDP2 p.Ile64Phe Uncertain significance Single submitter
- CNDP2 p.Met240Leu Uncertain significance Single submitter
- CNDP2 p.Pro76Leu Uncertain significance Single submitter
- CNDP2 p.Ser235Leu Uncertain significance Single submitter
- CNDP2 p.Ser249Phe Uncertain significance Single submitter
- CNDP2 p.Thr93Asn Uncertain significance Single submitter
- CNDP2 p.Tyr190Cys Uncertain significance Single submitter
- CNDP2 p.Tyr377Cys Uncertain significance Single submitter
- CNDP2 p.Val31Met Uncertain significance Single submitter
All CNDP2 variants
Benign 2
- c.1211-8C>A Multiple submitters
- p.Pro35Leu Multiple submitters ⚠
Likely benign 5
- c.367+9C>T Single submitter
- p.Ala138= Single submitter
- p.Arg369His Single submitter
- p.Gly354Ser Single submitter
- p.Leu162= Single submitter
Uncertain significance 79
- p.Thr403Ala Multiple submitters ⚠
- p.Ala23Ser Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala322Gly Single submitter ⚠
- p.Ala322Thr Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala396Pro Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala400Thr Single submitter ⚠
- p.Ala440Val Single submitter ⚠
- p.Arg211Gly Single submitter ⚠
- p.Arg254Met Single submitter ⚠
- p.Arg308Ter Single submitter
- p.Arg369Cys Single submitter ⚠
- p.Arg84Met Single submitter ⚠
- p.Asp101Asn Single submitter ⚠
- p.Asp112Gly Single submitter ⚠
- p.Asp16Asn Single submitter ⚠
- p.Asp174Asn Single submitter
- p.Asp174Gly Single submitter ⚠
- p.Asp252Gly Single submitter
- p.Asp283Gly Single submitter
- p.Cys95Arg Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu271Gly Single submitter ⚠
- p.Glu285Lys Single submitter ⚠
- p.Glu320Gln Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.Glu373Asp Single submitter ⚠
- p.Gly139Ser Single submitter ⚠
- p.Gly151Val Single submitter ⚠
- p.Gly209Ser Single submitter ⚠
- p.Gly233Ala Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly261Arg Single submitter
- p.Gly261Ser Single submitter ⚠
- p.Gly338Asp Single submitter ⚠
- p.Gly379Ser Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.Gly56Arg Single submitter
- p.Gly65Ala Single submitter ⚠
- p.Gly83Ser Single submitter
- p.His317Arg Single submitter ⚠
- p.Ile11Met Single submitter ⚠
- p.Ile154Phe Single submitter ⚠
- p.Ile28Val Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Ile64Phe Single submitter ⚠
- p.Ile80Val Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Leu144Met Single submitter ⚠
- p.Leu316Arg Single submitter ⚠
- p.Lys201Asn Single submitter ⚠
- p.Lys275Arg Single submitter ⚠
- p.Lys375Arg Single submitter ⚠
- p.Met240Leu Single submitter ⚠
- p.Phe340Tyr Single submitter ⚠
- p.Pro115Ala Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro204Ala Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser223Thr Single submitter ⚠
- p.Ser235Leu Single submitter ⚠
- p.Ser249Phe Single submitter ⚠
- p.Ser30Ile Single submitter ⚠
- p.Thr349Ala Single submitter ⚠
- p.Thr362Asn Single submitter ⚠
- p.Thr428Met Single submitter ⚠
- p.Thr93Asn Single submitter ⚠
- p.Tyr190Cys Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Val266Leu Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val345Met Single submitter ⚠
- p.Val420Met Single submitter ⚠
- p.Val94Met Single submitter ⚠