CNFN — 13 ClinVar variants
All ClinVar germline CNFN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
13 Uncertain significance
Full CNFN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNFN p.Ala49Ser Uncertain significance Single submitter
- CNFN p.Ala91Val Uncertain significance Single submitter
- CNFN p.Asp55Asn Uncertain significance Single submitter
- CNFN p.Cys11Gly Uncertain significance Single submitter
- CNFN p.Cys61Ser Uncertain significance Single submitter
- CNFN p.Leu46Pro Uncertain significance Single submitter
- CNFN p.Met76Ile Uncertain significance Single submitter
- CNFN p.Tyr80Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CNFN variants
Uncertain significance 13
- p.Ala49Ser Single submitter ⚠
- p.Ala91Ser Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Asp55Asn Single submitter ⚠
- p.Cys11Gly Single submitter ⚠
- p.Cys47Phe Single submitter ⚠
- p.Cys59Gly Single submitter ⚠
- p.Cys61Ser Single submitter ⚠
- p.Gly27Ala Single submitter ⚠
- p.Gly68Cys Single submitter ⚠
- p.Leu46Pro Single submitter ⚠
- p.Met76Ile Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠