CNN3 — 25 ClinVar variants
All ClinVar germline CNN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full CNN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNN3 p.Asn114Ser Uncertain significance Single submitter
- CNN3 p.Asn34Ser Uncertain significance Single submitter
- CNN3 p.Asp196Gly Uncertain significance Single submitter
- CNN3 p.Asp324Asn Uncertain significance Single submitter
- CNN3 p.Glu294Asp Uncertain significance Single submitter
- CNN3 p.Glu84Asp Uncertain significance Single submitter
- CNN3 p.Ile327Val Uncertain significance Single submitter
- CNN3 p.Ile44Val Uncertain significance Single submitter
- CNN3 p.Ile86Thr Uncertain significance Single submitter
- CNN3 p.Leu220Val Uncertain significance Single submitter
- CNN3 p.Lys192Arg Uncertain significance Single submitter
- CNN3 p.Met98Val Uncertain significance Single submitter
- CNN3 p.Ser162Gly Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CNN3 p.Ala217Thr Uncertain significance Single submitter
- CNN3 p.Asp230Asn Uncertain significance Single submitter
- CNN3 p.Glu146Asp Uncertain significance Single submitter
- CNN3 p.Glu311Lys Uncertain significance Single submitter
- CNN3 p.Ile140Thr Uncertain significance Single submitter
- CNN3 p.Pro270Ser Uncertain significance Single submitter
- CNN3 p.Pro67Ser Uncertain significance Single submitter
- CNN3 p.Ser241Leu Uncertain significance Single submitter
- CNN3 p.Ser293Trp Uncertain significance Single submitter
- CNN3 p.Tyr268Cys Uncertain significance Single submitter
- CNN3 p.Tyr320His Uncertain significance Single submitter
- CNN3 p.Val16Ile Uncertain significance Single submitter
All CNN3 variants
Uncertain significance 25
- p.Ala217Thr Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn34Ser Single submitter ⚠
- p.Asp196Gly Single submitter ⚠
- p.Asp230Asn Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Glu146Asp Single submitter ⚠
- p.Glu294Asp Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu84Asp Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Ile327Val Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Ile86Thr Single submitter ⚠
- p.Leu220Val Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Met98Val Single submitter ⚠
- p.Pro270Ser Single submitter ⚠
- p.Pro67Ser Single submitter ⚠
- p.Ser162Gly Single submitter ⚠
- p.Ser241Leu Single submitter ⚠
- p.Ser293Trp Single submitter ⚠
- p.Tyr268Cys Single submitter ⚠
- p.Tyr320His Single submitter ⚠
- p.Val16Ile Single submitter ⚠