CNNM3 — 140 ClinVar variants

All ClinVar germline CNNM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →

3 Likely benign · 137 Uncertain significance

Full CNNM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 137

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 72

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 65

The independent predictors disagree with each other — read with care.

All CNNM3 variants

Likely benign 3

p.Asn657Ser Single submitter
p.Val49Ala Single submitter
p.Val5Ala Single submitter

Uncertain significance 137

p.Ala221Gly Multiple submitters ⚠
p.Ala128Val Single submitter ⚠
p.Ala142Thr Single submitter ⚠
p.Ala146Val Single submitter ⚠
p.Ala158Thr Single submitter ⚠
p.Ala162Glu Single submitter ⚠
p.Ala176Thr Single submitter ⚠
p.Ala191Thr Single submitter ⚠
p.Ala194Asp Single submitter ⚠
p.Ala197Val Single submitter ⚠
p.Ala202Gly Single submitter ⚠
p.Ala207Val Single submitter ⚠
p.Ala242Asp Single submitter ⚠
p.Ala24Thr Single submitter ⚠
p.Ala252Val Single submitter ⚠
p.Ala255Glu Single submitter ⚠
p.Ala294Gly Single submitter ⚠
p.Ala294Thr Single submitter ⚠
p.Ala329Thr Single submitter ⚠
p.Ala329Val Single submitter ⚠
p.Ala339Pro Single submitter ⚠
p.Ala4Val Single submitter ⚠
p.Ala53Val Single submitter ⚠
p.Ala54Val Single submitter ⚠
p.Ala623Val Single submitter ⚠
p.Ala685Val Single submitter ⚠
p.Ala72Ser Single submitter ⚠
p.Ala72Val Single submitter ⚠
p.Ala7Val Single submitter ⚠
p.Ala80Asp Single submitter ⚠
p.Ala80Ser Single submitter ⚠
p.Ala8Val Single submitter ⚠
p.Arg102Gly Single submitter ⚠
p.Arg106Leu Single submitter ⚠
p.Arg10Gly Single submitter ⚠
p.Arg10Trp Single submitter ⚠
p.Arg182Gln Single submitter ⚠
p.Arg183Cys Single submitter ⚠
p.Arg188Gly Single submitter ⚠
p.Arg188Trp Single submitter ⚠
p.Arg189Cys Single submitter ⚠
p.Arg215Cys Single submitter ⚠
p.Arg246Leu Single submitter ⚠
p.Arg289Trp Single submitter ⚠
p.Arg32Pro Single submitter ⚠
p.Arg356Cys Single submitter ⚠
p.Arg502Cys Single submitter ⚠
p.Arg506Gln Single submitter ⚠
p.Arg515Cys Single submitter ⚠
p.Arg608Gly Single submitter ⚠
p.Arg654Gly Single submitter ⚠
p.Arg98Cys Single submitter ⚠
p.Asn387Ser Single submitter ⚠
p.Asp303Ala Single submitter ⚠
p.Asp334His Single submitter ⚠
p.Asp372Glu Single submitter ⚠
p.Asp41Gly Single submitter ⚠
p.Cys86Arg Single submitter ⚠
p.Gln155Arg Single submitter ⚠
p.Gln167Arg Single submitter ⚠
p.Gln167Lys Single submitter ⚠
p.Gln219Arg Single submitter ⚠
p.Glu26Lys Single submitter ⚠
p.Glu422Lys Single submitter ⚠
p.Glu430Lys Single submitter ⚠
p.Glu454Lys Single submitter ⚠
p.Glu518Gly Single submitter ⚠
p.Glu578Lys Single submitter ⚠
p.Gly126Trp Single submitter ⚠
p.Gly12Ala Single submitter ⚠
p.Gly227Ser Single submitter ⚠
p.Gly298Ser Single submitter ⚠
p.Gly35Asp Single submitter ⚠
p.Gly47Val Single submitter ⚠
p.Gly571Arg Single submitter ⚠
p.Gly672Ser Single submitter ⚠
p.Gly679Asp Single submitter ⚠
p.Gly694Ser Single submitter ⚠
p.Gly702Glu Single submitter ⚠
p.Gly706Asp Single submitter ⚠
p.Gly85Ser Single submitter ⚠
p.His113Tyr Single submitter ⚠
p.Ile441Thr Single submitter ⚠
p.Ile445Leu Single submitter ⚠
p.Leu105Val Single submitter ⚠
p.Leu139Met Single submitter ⚠
p.Leu159Arg Single submitter ⚠
p.Leu251Pro Single submitter ⚠
p.Leu267Val Single submitter ⚠
p.Leu276Val Single submitter ⚠
p.Leu279Val Single submitter ⚠
p.Leu293Arg Single submitter ⚠
p.Leu304Ile Single submitter ⚠
p.Leu318Arg Single submitter ⚠
p.Leu480Ser Single submitter ⚠
p.Leu548Val Single submitter ⚠
p.Leu63Val Single submitter ⚠
p.Leu66Phe Single submitter ⚠
p.Lys475Glu Single submitter ⚠
p.Lys681Thr Single submitter ⚠
p.Met362Leu Single submitter ⚠
p.Phe71Val Single submitter ⚠
p.Pro112Gln Single submitter ⚠
p.Pro133Leu Single submitter ⚠
p.Pro163Ser Single submitter ⚠
p.Pro186Leu Single submitter ⚠
p.Pro29Leu Single submitter ⚠
p.Pro378Thr Single submitter ⚠
p.Pro554Leu Single submitter ⚠
p.Pro600Thr Single submitter ⚠
p.Pro693His Single submitter ⚠
p.Pro705Leu Single submitter ⚠
p.Ser114Leu Single submitter ⚠
p.Ser411Phe Single submitter ⚠
p.Ser661Phe Single submitter ⚠
p.Ser74Thr Single submitter ⚠
p.Thr266Ser Single submitter ⚠
p.Thr383Ile Single submitter ⚠
p.Thr500Pro Single submitter ⚠
p.Thr583Met Single submitter ⚠
p.Thr619Met Single submitter ⚠
p.Thr683Ser Single submitter ⚠
p.Trp135Arg Single submitter ⚠
p.Tyr584Cys Single submitter ⚠
p.Tyr624Cys Single submitter ⚠
p.Val110Gly Single submitter ⚠
p.Val119Met Single submitter ⚠
p.Val166Ala Single submitter ⚠
p.Val211Ala Single submitter ⚠
p.Val360Leu Single submitter ⚠
p.Val440Met Single submitter ⚠
p.Val460Leu Single submitter ⚠
p.Val483Ala Single submitter ⚠
p.Val490Ile Single submitter ⚠
p.Val510Ile Single submitter ⚠
p.Val630Leu Single submitter ⚠
p.Val707Phe Single submitter ⚠