Sugi Variant

Sugi Variant/CNNM4

CNNM4 — 555 ClinVar variants

All ClinVar germline CNNM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 248 flagged for review →

31 Pathogenic · 2 Pathogenic/Likely pathogenic · 14 Likely pathogenic · 16 Conflicting · 20 Benign · 4 Benign/Likely benign · 181 Likely benign · 287 Uncertain significance

Full CNNM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 248

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 154

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 154

Predictors split 91

The independent predictors disagree with each other — read with care.

All CNNM4 variants

Pathogenic 31

Pathogenic/Likely pathogenic 2

Likely pathogenic 14

Conflicting classifications of pathogenicity 16

Benign 20

Benign/Likely benign 4

Likely benign 181

Uncertain significance 287