CNOT11 — 29 ClinVar variants
All ClinVar germline CNOT11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Likely benign · 28 Uncertain significance
Full CNOT11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNOT11 p.Arg202His Uncertain significance Single submitter
- CNOT11 p.Arg60Ser Uncertain significance Single submitter
- CNOT11 p.Asp307Glu Uncertain significance Single submitter
- CNOT11 p.Gly36Ser Uncertain significance Single submitter
- CNOT11 p.Gly53Ala Uncertain significance Single submitter
- CNOT11 p.Gly59Ser Uncertain significance Single submitter
- CNOT11 p.Ile293Met Uncertain significance Single submitter
- CNOT11 p.Leu456Phe Uncertain significance Single submitter
- CNOT11 p.Lys314Thr Uncertain significance Single submitter
- CNOT11 p.Met189Leu Uncertain significance Single submitter
- CNOT11 p.Met212Val Uncertain significance Single submitter
- CNOT11 p.Pro158Ala Uncertain significance Single submitter
- CNOT11 p.Pro288Leu Uncertain significance Single submitter
- CNOT11 p.Pro2Leu Uncertain significance Single submitter
- CNOT11 p.Pro57Ser Uncertain significance Single submitter
- CNOT11 p.Ser120Gly Uncertain significance Single submitter
- CNOT11 p.Thr178Ser Uncertain significance Single submitter
- CNOT11 p.Thr304Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CNOT11 p.Ala365Pro Uncertain significance Single submitter
- CNOT11 p.Arg202Cys Uncertain significance Single submitter
- CNOT11 p.Arg286Cys Uncertain significance Single submitter
- CNOT11 p.Gln203His Uncertain significance Single submitter
- CNOT11 p.His279Arg Uncertain significance Single submitter
- CNOT11 p.Leu117Val Uncertain significance Single submitter
- CNOT11 p.Met110Ile Uncertain significance Single submitter
- CNOT11 p.Pro287Ser Uncertain significance Single submitter
- CNOT11 p.Pro54Leu Uncertain significance Single submitter
- CNOT11 p.Ser49Phe Uncertain significance Single submitter
All CNOT11 variants
Likely benign 1
- p.Thr435= Single submitter
Uncertain significance 28
- p.Ala365Pro Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg286Cys Single submitter ⚠
- p.Arg60Ser Single submitter ⚠
- p.Asp307Glu Single submitter ⚠
- p.Gln203His Single submitter ⚠
- p.Gly36Ser Single submitter ⚠
- p.Gly53Ala Single submitter ⚠
- p.Gly59Ser Single submitter ⚠
- p.His279Arg Single submitter ⚠
- p.Ile293Met Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu456Phe Single submitter ⚠
- p.Lys314Thr Single submitter ⚠
- p.Met110Ile Single submitter ⚠
- p.Met189Leu Single submitter ⚠
- p.Met212Val Single submitter ⚠
- p.Pro158Ala Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro288Leu Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Ser120Gly Single submitter ⚠
- p.Ser49Phe Single submitter ⚠
- p.Thr178Ser Single submitter ⚠
- p.Thr304Met Single submitter ⚠