CNOT4 — 54 ClinVar variants
All ClinVar germline CNOT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
54 Uncertain significance
Full CNOT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNOT4 p.Ala101Ser Uncertain significance Single submitter
- CNOT4 p.Ala459Thr Uncertain significance Single submitter
- CNOT4 p.Arg323Gln Uncertain significance Single submitter
- CNOT4 p.Arg342His Uncertain significance Single submitter
- CNOT4 p.Arg3Cys Uncertain significance Single submitter
- CNOT4 p.Arg497Leu Uncertain significance Single submitter
- CNOT4 p.Arg505His Uncertain significance Single submitter
- CNOT4 p.Asn319Ser Uncertain significance Single submitter
- CNOT4 p.Asp289Gly Uncertain significance Single submitter
- CNOT4 p.Gln480Pro Uncertain significance Single submitter
- CNOT4 p.His442Tyr Uncertain significance Single submitter
- CNOT4 p.His455Arg Uncertain significance Single submitter
- CNOT4 p.Ile419Met Uncertain significance Single submitter
- CNOT4 p.Leu436Val Uncertain significance Single submitter
- CNOT4 p.Leu472Met Uncertain significance Single submitter
- CNOT4 p.Pro429Ala Uncertain significance Single submitter
- CNOT4 p.Pro433Leu Uncertain significance Single submitter
- CNOT4 p.Pro529Arg Uncertain significance Single submitter
- CNOT4 p.Ser435Pro Uncertain significance Single submitter
- CNOT4 p.Ser470Pro Uncertain significance Single submitter
- CNOT4 p.Ser507Thr Uncertain significance Single submitter
- CNOT4 p.Thr267Ala Uncertain significance Single submitter
- CNOT4 p.Thr331Ala Uncertain significance Single submitter
- CNOT4 p.Thr445Ala Uncertain significance Single submitter
- CNOT4 p.Val111Leu Uncertain significance Single submitter
- CNOT4 p.Val142Ala Uncertain significance Single submitter
- CNOT4 p.Val259Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CNOT4 p.Asn250His Uncertain significance Single submitter
- CNOT4 p.Asp281Tyr Uncertain significance Single submitter
- CNOT4 p.Ser321Gly Uncertain significance Single submitter
- CNOT4 p.Ser490Asn Uncertain significance Single submitter
- CNOT4 p.Thr256Met Uncertain significance Single submitter
- CNOT4 p.Val181Ile Uncertain significance Single submitter
All CNOT4 variants
Uncertain significance 54
- p.Ala101Ser Single submitter ⚠
- p.Ala459Thr Single submitter ⚠
- p.Ala583Thr Single submitter
- p.Ala587Val Single submitter
- p.Ala649Pro Single submitter
- p.Ala669Thr Single submitter
- p.Arg323Gln Single submitter ⚠
- p.Arg342His Single submitter ⚠
- p.Arg3Cys Single submitter ⚠
- p.Arg497Leu Single submitter ⚠
- p.Arg505His Single submitter ⚠
- p.Asn250His Single submitter ⚠
- p.Asn319Ser Single submitter ⚠
- p.Asn568Thr Single submitter
- p.Asn570Ser Single submitter
- p.Asp281Tyr Single submitter ⚠
- p.Asp289Gly Single submitter ⚠
- p.Gln480Pro Single submitter ⚠
- p.Gln653His Single submitter
- p.Gly572Asp Single submitter
- p.His442Tyr Single submitter ⚠
- p.His455Arg Single submitter ⚠
- p.Ile419Met Single submitter ⚠
- p.Ile615Val Single submitter
- p.Leu436Val Single submitter ⚠
- p.Leu472Met Single submitter ⚠
- p.Lys554Glu Single submitter
- p.Pro429Ala Single submitter ⚠
- p.Pro433Leu Single submitter ⚠
- p.Pro529Arg Single submitter ⚠
- p.Pro680Leu Single submitter
- p.Pro687Leu Single submitter
- p.Pro688Gln Single submitter
- p.Pro696Thr Single submitter
- p.Pro697Ala Single submitter
- p.Pro697Leu Single submitter
- p.Ser321Gly Single submitter ⚠
- p.Ser435Pro Single submitter ⚠
- p.Ser470Pro Single submitter ⚠
- p.Ser490Asn Single submitter ⚠
- p.Ser507Thr Single submitter ⚠
- p.Ser577Ala Single submitter
- p.Ser597Gly Single submitter
- p.Ser625Cys Single submitter
- p.Thr256Met Single submitter ⚠
- p.Thr267Ala Single submitter ⚠
- p.Thr331Ala Single submitter ⚠
- p.Thr445Ala Single submitter ⚠
- p.Thr702Pro Single submitter
- p.Thr709Ala Single submitter
- p.Val111Leu Single submitter ⚠
- p.Val142Ala Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val259Ala Single submitter ⚠