CNR2 — 52 ClinVar variants
All ClinVar germline CNR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Benign · 1 Likely benign · 49 Uncertain significance
Full CNR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNR2 p.Ala199Thr Uncertain significance Single submitter
- CNR2 p.Ala328Val Uncertain significance Single submitter
- CNR2 p.Ala332Ser Uncertain significance Single submitter
- CNR2 p.Ala342Ser Uncertain significance Single submitter
- CNR2 p.Arg147Cys Uncertain significance Single submitter
- CNR2 p.Arg236Gln Uncertain significance Single submitter
- CNR2 p.Arg242Lys Uncertain significance Single submitter
- CNR2 p.Arg302Gln Uncertain significance Single submitter
- CNR2 p.Arg334Ile Uncertain significance Single submitter
- CNR2 p.Asn20Lys Uncertain significance Single submitter
- CNR2 p.Asp15Tyr Uncertain significance Single submitter
- CNR2 p.Asp24Tyr Uncertain significance Single submitter
- CNR2 p.Asp354His Uncertain significance Single submitter
- CNR2 p.Cys89Tyr Uncertain significance Single submitter
- CNR2 p.Glu330Ala Uncertain significance Single submitter
- CNR2 p.Glu330Lys Uncertain significance Single submitter
- CNR2 p.Gly233Glu Uncertain significance Single submitter
- CNR2 p.Gly30Asp Uncertain significance Single submitter
- CNR2 p.His211Leu Uncertain significance Single submitter
- CNR2 p.Ile110Met Uncertain significance Single submitter
- CNR2 p.Ile110Thr Uncertain significance Single submitter
- CNR2 p.Ile186Asn Uncertain significance Single submitter
- CNR2 p.Ile73Phe Uncertain significance Single submitter
- CNR2 p.Ile9Thr Uncertain significance Single submitter
- CNR2 p.Lys142Arg Uncertain significance Single submitter
- CNR2 p.Lys23Arg Uncertain significance Single submitter
- CNR2 p.Lys319Asn Uncertain significance Single submitter
- CNR2 p.Met22Ile Uncertain significance Single submitter
- CNR2 p.Met22Leu Uncertain significance Single submitter
- CNR2 p.Met22Val Uncertain significance Single submitter
- CNR2 p.Pro260Arg Uncertain significance Single submitter
- CNR2 p.Pro296Ser Uncertain significance Single submitter
- CNR2 p.Pro31Leu Uncertain significance Single submitter
- CNR2 p.Pro333Leu Uncertain significance Single submitter
- CNR2 p.Ser13Cys Uncertain significance Single submitter
- CNR2 p.Ser19Tyr Uncertain significance Single submitter
- CNR2 p.Ser61Pro Uncertain significance Single submitter
- CNR2 p.Thr146Ile Uncertain significance Single submitter
- CNR2 p.Thr41Ile Uncertain significance Single submitter
- CNR2 p.Trp194Cys Uncertain significance Single submitter
- CNR2 p.Tyr70His Uncertain significance Single submitter
- CNR2 p.Val159Phe Uncertain significance Single submitter
- CNR2 p.Val164Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CNR2 p.Arg302Trp Uncertain significance Single submitter
- CNR2 p.Ile73Thr Uncertain significance Single submitter
- CNR2 p.Phe106Ser Uncertain significance Single submitter
- CNR2 p.Pro68Thr Uncertain significance Single submitter
- CNR2 p.Ser13Phe Uncertain significance Single submitter
- CNR2 p.Ser308Phe Uncertain significance Single submitter
All CNR2 variants
Benign 2
- p.Arg66Gln Multiple submitters
- p.Cys313= Multiple submitters
Likely benign 1
- p.Phe97= Single submitter
Uncertain significance 49
- p.Ala199Thr Single submitter ⚠
- p.Ala328Val Single submitter ⚠
- p.Ala332Ser Single submitter ⚠
- p.Ala342Ser Single submitter ⚠
- p.Arg147Cys Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg242Lys Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg334Ile Single submitter ⚠
- p.Asn20Lys Single submitter ⚠
- p.Asp15Tyr Single submitter ⚠
- p.Asp24Tyr Single submitter ⚠
- p.Asp354His Single submitter ⚠
- p.Cys89Tyr Single submitter ⚠
- p.Glu330Ala Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Gly233Glu Single submitter ⚠
- p.Gly30Asp Single submitter ⚠
- p.His211Leu Single submitter ⚠
- p.Ile110Met Single submitter ⚠
- p.Ile110Thr Single submitter ⚠
- p.Ile186Asn Single submitter ⚠
- p.Ile73Phe Single submitter ⚠
- p.Ile73Thr Single submitter ⚠
- p.Ile9Thr Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys23Arg Single submitter ⚠
- p.Lys319Asn Single submitter ⚠
- p.Met22Ile Single submitter ⚠
- p.Met22Leu Single submitter ⚠
- p.Met22Val Single submitter ⚠
- p.Phe106Ser Single submitter ⚠
- p.Pro260Arg Single submitter ⚠
- p.Pro296Ser Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Pro68Thr Single submitter ⚠
- p.Ser13Cys Single submitter ⚠
- p.Ser13Phe Single submitter ⚠
- p.Ser19Tyr Single submitter ⚠
- p.Ser308Phe Single submitter ⚠
- p.Ser61Pro Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr41Ile Single submitter ⚠
- p.Trp194Cys Single submitter ⚠
- p.Tyr70His Single submitter ⚠
- p.Val159Phe Single submitter ⚠
- p.Val164Ile Single submitter ⚠