CNRIP1 — 20 ClinVar variants
All ClinVar germline CNRIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
20 Uncertain significance
Full CNRIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNRIP1 p.Arg102Gln Uncertain significance Single submitter
- CNRIP1 p.Asp20Glu Uncertain significance Single submitter
- CNRIP1 p.Gly66Val Uncertain significance Single submitter
- CNRIP1 p.Leu57Gln Uncertain significance Single submitter
- CNRIP1 p.Pro110Leu Uncertain significance Single submitter
- CNRIP1 p.Pro110Thr Uncertain significance Single submitter
- CNRIP1 p.Thr86Met Uncertain significance Single submitter
- CNRIP1 p.Val123Ile Uncertain significance Single submitter
- CNRIP1 p.Val48Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CNRIP1 p.Arg131Gln Uncertain significance Single submitter
- CNRIP1 p.Arg131Trp Uncertain significance Single submitter
- CNRIP1 p.Arg15Ser Uncertain significance Single submitter
- CNRIP1 p.Arg9Leu Uncertain significance Single submitter
- CNRIP1 p.Glu118Lys Uncertain significance Single submitter
- CNRIP1 p.Ile52Thr Uncertain significance Single submitter
- CNRIP1 p.Leu57Pro Uncertain significance Single submitter
- CNRIP1 p.Lys130Glu Uncertain significance Single submitter
- CNRIP1 p.Phe111Leu Uncertain significance Single submitter
- CNRIP1 p.Pro104Ser Uncertain significance Single submitter
- CNRIP1 p.Val27Met Uncertain significance Single submitter
All CNRIP1 variants
Uncertain significance 20
- p.Arg102Gln Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg131Trp Single submitter ⚠
- p.Arg15Ser Single submitter ⚠
- p.Arg9Leu Single submitter ⚠
- p.Asp20Glu Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.Ile52Thr Single submitter ⚠
- p.Leu57Gln Single submitter ⚠
- p.Leu57Pro Single submitter ⚠
- p.Lys130Glu Single submitter ⚠
- p.Phe111Leu Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro110Thr Single submitter ⚠
- p.Thr86Met Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val27Met Single submitter ⚠
- p.Val48Ala Single submitter ⚠