CNST — 105 ClinVar variants
All ClinVar germline CNST variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
3 Likely benign · 102 Uncertain significance
Full CNST gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNST p.Ala134Pro Uncertain significance Single submitter
- CNST p.Ala144Thr Uncertain significance Single submitter
- CNST p.Ala403Ser Uncertain significance Single submitter
- CNST p.Ala407Ser Uncertain significance Single submitter
- CNST p.Ala499Val Uncertain significance Single submitter
- CNST p.Ala635Val Uncertain significance Single submitter
- CNST p.Arg115Ile Uncertain significance Single submitter
- CNST p.Arg115Ser Uncertain significance Single submitter
- CNST p.Arg217Gln Uncertain significance Single submitter
- CNST p.Arg27Lys Uncertain significance Single submitter
- CNST p.Arg441Cys Uncertain significance Single submitter
- CNST p.Arg461Cys Uncertain significance Single submitter
- CNST p.Arg461His Uncertain significance Single submitter
- CNST p.Arg607Lys Uncertain significance Single submitter
- CNST p.Asn479Ser Uncertain significance Single submitter
- CNST p.Asn541Ile Uncertain significance Single submitter
- CNST p.Asn568Asp Uncertain significance Single submitter
- CNST p.Asn89Lys Uncertain significance Single submitter
- CNST p.Asp3Gly Uncertain significance Single submitter
- CNST p.Asp440Tyr Uncertain significance Single submitter
- CNST p.Asp504Gly Uncertain significance Single submitter
- CNST p.Asp504His Uncertain significance Single submitter
- CNST p.Asp535His Uncertain significance Single submitter
- CNST p.Asp571Asn Uncertain significance Single submitter
- CNST p.Asp572His Uncertain significance Single submitter
- CNST p.Asp572Tyr Uncertain significance Single submitter
- CNST p.Asp5Asn Uncertain significance Single submitter
- CNST p.Asp702Glu Uncertain significance Single submitter
- CNST p.Cys338Tyr Uncertain significance Single submitter
- CNST p.Cys672Trp Uncertain significance Single submitter
- CNST p.Gln138Glu Uncertain significance Single submitter
- CNST p.Gln295His Uncertain significance Single submitter
- CNST p.Gln401His Uncertain significance Single submitter
- CNST p.Gln475Leu Uncertain significance Single submitter
- CNST p.Gln569Lys Uncertain significance Single submitter
- CNST p.Gln713His Uncertain significance Single submitter
- CNST p.Glu161Val Uncertain significance Single submitter
- CNST p.Glu311Gln Uncertain significance Single submitter
- CNST p.Glu313Gly Uncertain significance Single submitter
- CNST p.Gly258Ser Uncertain significance Single submitter
- CNST p.Gly306Glu Uncertain significance Single submitter
- CNST p.Gly319Val Uncertain significance Single submitter
- CNST p.Gly416Ser Uncertain significance Single submitter
- CNST p.Gly438Arg Uncertain significance Single submitter
- CNST p.Gly438Asp Uncertain significance Single submitter
- CNST p.Gly505Cys Uncertain significance Single submitter
- CNST p.Gly512Arg Uncertain significance Single submitter
- CNST p.Gly520Arg Uncertain significance Single submitter
- CNST p.Gly520Asp Uncertain significance Single submitter
- CNST p.Gly661Glu Uncertain significance Single submitter
- CNST p.Gly663Asp Uncertain significance Single submitter
- CNST p.Gly690Ser Uncertain significance Single submitter
- CNST p.His633Tyr Uncertain significance Single submitter
- CNST p.Ile13Met Uncertain significance Single submitter
- CNST p.Ile196Met Uncertain significance Single submitter
- CNST p.Leu142Val Uncertain significance Single submitter
- CNST p.Leu168Pro Uncertain significance Single submitter
- CNST p.Leu193His Uncertain significance Single submitter
- CNST p.Leu249Val Uncertain significance Single submitter
- CNST p.Leu43Phe Uncertain significance Single submitter
- CNST p.Leu43Pro Uncertain significance Single submitter
- CNST p.Leu523Phe Uncertain significance Single submitter
- CNST p.Leu77Trp Uncertain significance Single submitter
- CNST p.Lys123Arg Uncertain significance Single submitter
- CNST p.Lys123Gln Uncertain significance Single submitter
- CNST p.Lys167Glu Uncertain significance Single submitter
- CNST p.Lys254Glu Uncertain significance Single submitter
- CNST p.Lys266Thr Uncertain significance Single submitter
- CNST p.Lys310Arg Uncertain significance Single submitter
- CNST p.Lys533Arg Uncertain significance Single submitter
- CNST p.Lys710Glu Uncertain significance Single submitter
- CNST p.Met137Arg Uncertain significance Single submitter
- CNST p.Met342Ile Uncertain significance Single submitter
- CNST p.Met704Thr Uncertain significance Single submitter
- CNST p.Pro109Leu Uncertain significance Single submitter
- CNST p.Pro166Leu Uncertain significance Single submitter
- CNST p.Pro302Ala Uncertain significance Single submitter
- CNST p.Pro33Leu Uncertain significance Single submitter
- CNST p.Pro387Leu Uncertain significance Single submitter
- CNST p.Pro472Leu Uncertain significance Single submitter
- CNST p.Ser116Asn Uncertain significance Single submitter
- CNST p.Ser335Asn Uncertain significance Single submitter
- CNST p.Ser352Leu Uncertain significance Single submitter
- CNST p.Ser389Phe Uncertain significance Single submitter
- CNST p.Ser562Tyr Uncertain significance Single submitter
- CNST p.Ser64Cys Uncertain significance Single submitter
- CNST p.Thr247Met Uncertain significance Single submitter
- CNST p.Thr370Arg Uncertain significance Single submitter
- CNST p.Tyr586Cys Uncertain significance Single submitter
- CNST p.Tyr686Cys Uncertain significance Single submitter
- CNST p.Tyr9Cys Uncertain significance Single submitter
- CNST p.Val149Ile Uncertain significance Single submitter
- CNST p.Val181Phe Uncertain significance Single submitter
- CNST p.Val284Met Uncertain significance Single submitter
- CNST p.Val330Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CNST variants
Likely benign 3
- p.Arg441His Single submitter
- p.His328Arg Single submitter
- p.Pro384Arg Single submitter
Uncertain significance 102
- p.Ala134Pro Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala403Ser Single submitter ⚠
- p.Ala407Ser Single submitter ⚠
- p.Ala499Val Single submitter ⚠
- p.Ala635Val Single submitter ⚠
- p.Arg115Ile Single submitter ⚠
- p.Arg115Ser Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg217Leu Single submitter ⚠
- p.Arg27Lys Single submitter ⚠
- p.Arg441Cys Single submitter ⚠
- p.Arg461Cys Single submitter ⚠
- p.Arg461His Single submitter ⚠
- p.Arg607Lys Single submitter ⚠
- p.Asn479Ser Single submitter ⚠
- p.Asn541Ile Single submitter ⚠
- p.Asn568Asp Single submitter ⚠
- p.Asn89Lys Single submitter ⚠
- p.Asp3Gly Single submitter ⚠
- p.Asp440Tyr Single submitter ⚠
- p.Asp504Gly Single submitter ⚠
- p.Asp504His Single submitter ⚠
- p.Asp535His Single submitter ⚠
- p.Asp571Asn Single submitter ⚠
- p.Asp572His Single submitter ⚠
- p.Asp572Tyr Single submitter ⚠
- p.Asp5Asn Single submitter ⚠
- p.Asp702Glu Single submitter ⚠
- p.Cys338Tyr Single submitter ⚠
- p.Cys672Trp Single submitter ⚠
- p.Gln138Glu Single submitter ⚠
- p.Gln295His Single submitter ⚠
- p.Gln401His Single submitter ⚠
- p.Gln475Leu Single submitter ⚠
- p.Gln569Lys Single submitter ⚠
- p.Gln713His Single submitter ⚠
- p.Glu161Val Single submitter ⚠
- p.Glu311Gln Single submitter ⚠
- p.Glu313Gly Single submitter ⚠
- p.Gly258Ser Single submitter ⚠
- p.Gly306Glu Single submitter ⚠
- p.Gly319Val Single submitter ⚠
- p.Gly416Ser Single submitter ⚠
- p.Gly438Arg Single submitter ⚠
- p.Gly438Asp Single submitter ⚠
- p.Gly505Cys Single submitter ⚠
- p.Gly512Arg Single submitter ⚠
- p.Gly520Arg Single submitter ⚠
- p.Gly520Asp Single submitter ⚠
- p.Gly661Glu Single submitter ⚠
- p.Gly663Asp Single submitter ⚠
- p.Gly690Ser Single submitter ⚠
- p.His633Tyr Single submitter ⚠
- p.Ile13Met Single submitter ⚠
- p.Ile177Thr Single submitter
- p.Ile196Met Single submitter ⚠
- p.Leu142Val Single submitter ⚠
- p.Leu168Pro Single submitter ⚠
- p.Leu193His Single submitter ⚠
- p.Leu249Val Single submitter ⚠
- p.Leu43Phe Single submitter ⚠
- p.Leu43Pro Single submitter ⚠
- p.Leu523Phe Single submitter ⚠
- p.Leu552Ser Single submitter ⚠
- p.Leu77Trp Single submitter ⚠
- p.Lys123Arg Single submitter ⚠
- p.Lys123Gln Single submitter ⚠
- p.Lys167Glu Single submitter ⚠
- p.Lys254Glu Single submitter ⚠
- p.Lys266Thr Single submitter ⚠
- p.Lys310Arg Single submitter ⚠
- p.Lys533Arg Single submitter ⚠
- p.Lys710Glu Single submitter ⚠
- p.Met137Arg Single submitter ⚠
- p.Met342Ile Single submitter ⚠
- p.Met704Thr Single submitter ⚠
- p.Pro109Leu Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro302Ala Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro387Leu Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Ser116Asn Single submitter ⚠
- p.Ser172Pro Single submitter ⚠
- p.Ser335Asn Single submitter ⚠
- p.Ser352Leu Single submitter ⚠
- p.Ser389Phe Single submitter ⚠
- p.Ser562Tyr Single submitter ⚠
- p.Ser64Cys Single submitter ⚠
- p.Thr247Met Single submitter ⚠
- p.Thr370Arg Single submitter ⚠
- p.Thr675Met Single submitter
- p.Trp238Arg Single submitter ⚠
- p.Tyr219Cys Single submitter ⚠
- p.Tyr586Cys Single submitter ⚠
- p.Tyr686Cys Single submitter ⚠
- p.Tyr9Cys Single submitter ⚠
- p.Val149Ile Single submitter ⚠
- p.Val181Phe Single submitter ⚠
- p.Val284Met Single submitter ⚠
- p.Val330Met Single submitter ⚠