CNTF — 47 ClinVar variants
All ClinVar germline CNTF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
2 Benign · 3 Likely benign · 42 Uncertain significance
Full CNTF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNTF p.Ala108Thr Uncertain significance Single submitter
- CNTF p.Ala117Val Uncertain significance Single submitter
- CNTF p.Arg136His Uncertain significance Single submitter
- CNTF p.Arg177His Uncertain significance Single submitter
- CNTF p.Arg19His Uncertain significance Single submitter
- CNTF p.Arg28His Uncertain significance Single submitter
- CNTF p.Arg89Met Uncertain significance Single submitter
- CNTF p.Arg89Thr Uncertain significance Single submitter
- CNTF p.Asn197Lys Uncertain significance Single submitter
- CNTF p.Asp51Gly Uncertain significance Single submitter
- CNTF p.Asp54Tyr Uncertain significance Single submitter
- CNTF p.Asp62His Uncertain significance Single submitter
- CNTF p.Gln122Glu Uncertain significance Single submitter
- CNTF p.Gln163Arg Uncertain significance Single submitter
- CNTF p.Gln183Pro Uncertain significance Single submitter
- CNTF p.Gly149Ser Uncertain significance Single submitter
- CNTF p.Gly150Ala Uncertain significance Single submitter
- CNTF p.Gly190Arg Uncertain significance Single submitter
- CNTF p.His97Gln Uncertain significance Single submitter
- CNTF p.Ile186Ser Uncertain significance Single submitter
- CNTF p.Ile194Val Uncertain significance Single submitter
- CNTF p.Leu165Arg Uncertain significance Single submitter
- CNTF p.Leu176Phe Uncertain significance Single submitter
- CNTF p.Leu23Pro Uncertain significance Single submitter
- CNTF p.Leu44Arg Uncertain significance Single submitter
- CNTF p.Leu50Met Uncertain significance Single submitter
- CNTF p.Leu9Arg Uncertain significance Single submitter
- CNTF p.Met56Leu Uncertain significance Single submitter
- CNTF p.Met56Thr Uncertain significance Single submitter
- CNTF p.Pro187Leu Uncertain significance Single submitter
- CNTF p.Pro8Leu Uncertain significance Single submitter
- CNTF p.Thr101Asn Uncertain significance Single submitter
- CNTF p.Thr35Arg Uncertain significance Single submitter
- CNTF p.Val96Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CNTF p.Arg13His Uncertain significance Single submitter
- CNTF p.Arg72Gln Uncertain significance Single submitter
- CNTF p.Gly158Ser Uncertain significance Single submitter
- CNTF p.Leu176Val Uncertain significance Single submitter
- CNTF p.Lys154Asn Uncertain significance Single submitter
- CNTF p.Pro135Leu Uncertain significance Single submitter
- CNTF p.Ser20Pro Uncertain significance Single submitter
All CNTF variants
Benign 2
- p.Asn49Ser Multiple submitters
- c.115-6G>A Single submitter
Likely benign 3
- p.Arg189Cys Single submitter
- p.Ile144Phe Single submitter
- p.Thr101Ala Single submitter
Uncertain significance 42
- p.Ala108Thr Single submitter ⚠
- p.Ala117Val Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg13His Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg19Leu Single submitter
- p.Arg28His Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg89Met Single submitter ⚠
- p.Arg89Thr Single submitter ⚠
- p.Asn197Lys Single submitter ⚠
- p.Asp51Gly Single submitter ⚠
- p.Asp54Tyr Single submitter ⚠
- p.Asp62His Single submitter ⚠
- p.Gln122Glu Single submitter ⚠
- p.Gln163Arg Single submitter ⚠
- p.Gln183Pro Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly150Ala Single submitter ⚠
- p.Gly158Ser Single submitter ⚠
- p.Gly190Arg Single submitter ⚠
- p.His97Gln Single submitter ⚠
- p.Ile186Ser Single submitter ⚠
- p.Ile194Val Single submitter ⚠
- p.Leu165Arg Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu176Val Single submitter ⚠
- p.Leu23Pro Single submitter ⚠
- p.Leu44Arg Single submitter ⚠
- p.Leu50Met Single submitter ⚠
- p.Leu9Arg Single submitter ⚠
- p.Lys154Asn Single submitter ⚠
- p.Met56Leu Single submitter ⚠
- p.Met56Thr Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser20Pro Single submitter ⚠
- p.Thr101Asn Single submitter ⚠
- p.Thr35Arg Single submitter ⚠
- p.Val96Leu Single submitter ⚠