CNTFR — 45 ClinVar variants
All ClinVar germline CNTFR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 43 Uncertain significance
Full CNTFR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNTFR p.Ala297Thr Uncertain significance Single submitter
- CNTFR p.Ala313Ser Uncertain significance Single submitter
- CNTFR p.Ala316Val Uncertain significance Single submitter
- CNTFR p.Ala367Thr Uncertain significance Single submitter
- CNTFR p.Ala3Val Uncertain significance Single submitter
- CNTFR p.Ala8Val Uncertain significance Single submitter
- CNTFR p.Arg213Gln Uncertain significance Single submitter
- CNTFR p.Arg58Gln Uncertain significance Single submitter
- CNTFR p.Asn70Asp Uncertain significance Single submitter
- CNTFR p.Gly343Ser Uncertain significance Single submitter
- CNTFR p.Gly71Asp Uncertain significance Single submitter
- CNTFR p.His96Gln Uncertain significance Single submitter
- CNTFR p.Ile287Thr Uncertain significance Single submitter
- CNTFR p.Leu114Val Uncertain significance Single submitter
- CNTFR p.Lys241Met Uncertain significance Single submitter
- CNTFR p.Met169Leu Uncertain significance Single submitter
- CNTFR p.Pro248Ser Uncertain significance Single submitter
- CNTFR p.Pro349Leu Uncertain significance Single submitter
- CNTFR p.Pro4Ala Uncertain significance Single submitter
- CNTFR p.Pro66Ser Uncertain significance Single submitter
- CNTFR p.Thr120Ser Uncertain significance Single submitter
- CNTFR p.Thr357Ile Uncertain significance Single submitter
- CNTFR p.Val354Ile Uncertain significance Single submitter
-
CNTFR p.Asp234His
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 21
The independent predictors disagree with each other — read with care.
- CNTFR p.Ala22Thr Likely benign Single submitter
- CNTFR p.Ala365Thr Likely benign Single submitter
- CNTFR p.Ala54Val Uncertain significance Single submitter
- CNTFR p.Arg167Cys Uncertain significance Single submitter
- CNTFR p.Arg220His Uncertain significance Single submitter
- CNTFR p.Arg37Cys Uncertain significance Single submitter
- CNTFR p.Arg37His Uncertain significance Single submitter
- CNTFR p.Arg98Cys Uncertain significance Single submitter
- CNTFR p.Asp234Glu Uncertain significance Single submitter
- CNTFR p.Cys9Tyr Uncertain significance Single submitter
- CNTFR p.Gly262Ser Uncertain significance Single submitter
- CNTFR p.Gly71Ser Uncertain significance Single submitter
- CNTFR p.Leu68Pro Uncertain significance Single submitter
- CNTFR p.Leu76Phe Uncertain significance Single submitter
- CNTFR p.Pro122Ser Uncertain significance Single submitter
- CNTFR p.Pro31Leu Uncertain significance Single submitter
- CNTFR p.Thr140Ile Uncertain significance Single submitter
- CNTFR p.Thr311Met Uncertain significance Single submitter
- CNTFR p.Thr323Ala Uncertain significance Single submitter
- CNTFR p.Thr331Ile Uncertain significance Single submitter
- CNTFR p.Val42Met Uncertain significance Single submitter
All CNTFR variants
Likely benign 2
- p.Ala22Thr Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
Uncertain significance 43
- p.Ala297Thr Single submitter ⚠
- p.Ala313Ser Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala367Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg37Cys Single submitter ⚠
- p.Arg37His Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Asn70Asp Single submitter ⚠
- p.Asp234Glu Single submitter ⚠
- p.Cys9Tyr Single submitter ⚠
- p.Gly262Ser Single submitter ⚠
- p.Gly343Ser Single submitter ⚠
- p.Gly71Asp Single submitter ⚠
- p.Gly71Ser Single submitter ⚠
- p.His96Gln Single submitter ⚠
- p.Ile287Thr Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Leu68Pro Single submitter ⚠
- p.Leu76Phe Single submitter ⚠
- p.Lys241Met Single submitter ⚠
- p.Met169Leu Single submitter ⚠
- p.Pro122Ser Single submitter ⚠
- p.Pro248Ser Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Pro4Ala Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Thr120Ser Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr311Met Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Thr331Ile Single submitter ⚠
- p.Thr357Ile Single submitter ⚠
- p.Val354Ile Single submitter ⚠
- p.Val42Met Single submitter ⚠
- p.Asp234His No assertion criteria prostate cancer ⚠