COLGALT2 — 96 ClinVar variants
All ClinVar germline COLGALT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
3 Likely benign · 93 Uncertain significance
Full COLGALT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COLGALT2 p.Ala142Val Uncertain significance Single submitter
- COLGALT2 p.Ala155Val Uncertain significance Single submitter
- COLGALT2 p.Ala271Val Uncertain significance Single submitter
- COLGALT2 p.Ala584Thr Uncertain significance Single submitter
- COLGALT2 p.Ala7Ser Uncertain significance Single submitter
- COLGALT2 p.Arg222Gln Uncertain significance Single submitter
- COLGALT2 p.Arg244Gly Uncertain significance Single submitter
- COLGALT2 p.Arg320His Uncertain significance Single submitter
- COLGALT2 p.Arg351Gly Uncertain significance Single submitter
- COLGALT2 p.Arg404Met Uncertain significance Single submitter
- COLGALT2 p.Arg440Cys Uncertain significance Single submitter
- COLGALT2 p.Arg470Gly Uncertain significance Single submitter
- COLGALT2 p.Arg589Lys Uncertain significance Single submitter
- COLGALT2 p.Arg596Gln Uncertain significance Single submitter
- COLGALT2 p.Arg596Trp Uncertain significance Single submitter
- COLGALT2 p.Asn382Ser Uncertain significance Single submitter
- COLGALT2 p.Asn514Ser Uncertain significance Single submitter
- COLGALT2 p.Asn63Lys Uncertain significance Single submitter
- COLGALT2 p.Asp399Asn Uncertain significance Single submitter
- COLGALT2 p.Asp426Glu Uncertain significance Single submitter
- COLGALT2 p.Asp492Asn Uncertain significance Single submitter
- COLGALT2 p.Asp579Asn Uncertain significance Single submitter
- COLGALT2 p.Asp586Asn Uncertain significance Single submitter
- COLGALT2 p.Asp618Asn Uncertain significance Single submitter
- COLGALT2 p.Gln149Pro Uncertain significance Single submitter
- COLGALT2 p.Gln508Arg Uncertain significance Single submitter
- COLGALT2 p.Glu125Lys Uncertain significance Single submitter
- COLGALT2 p.Glu130Lys Uncertain significance Single submitter
- COLGALT2 p.Glu287Gln Uncertain significance Single submitter
- COLGALT2 p.Glu40Gln Uncertain significance Single submitter
- COLGALT2 p.Glu537Lys Uncertain significance Single submitter
- COLGALT2 p.Glu543Gly Uncertain significance Single submitter
- COLGALT2 p.Gly39Arg Uncertain significance Single submitter
- COLGALT2 p.Gly73Cys Uncertain significance Single submitter
- COLGALT2 p.His135Arg Uncertain significance Single submitter
- COLGALT2 p.His443Asp Uncertain significance Single submitter
- COLGALT2 p.His533Arg Uncertain significance Single submitter
- COLGALT2 p.His70Pro Uncertain significance Single submitter
- COLGALT2 p.His70Tyr Uncertain significance Single submitter
- COLGALT2 p.Ile131Thr Uncertain significance Single submitter
- COLGALT2 p.Ile188Thr Uncertain significance Single submitter
- COLGALT2 p.Ile318Thr Uncertain significance Single submitter
- COLGALT2 p.Ile372Asn Uncertain significance Single submitter
- COLGALT2 p.Leu147Pro Uncertain significance Single submitter
- COLGALT2 p.Leu180Pro Uncertain significance Single submitter
- COLGALT2 p.Leu50Arg Uncertain significance Single submitter
- COLGALT2 p.Lys387Arg Uncertain significance Single submitter
- COLGALT2 p.Lys431Gln Uncertain significance Single submitter
- COLGALT2 p.Lys448Arg Uncertain significance Single submitter
- COLGALT2 p.Lys451Thr Uncertain significance Single submitter
- COLGALT2 p.Met192Arg Uncertain significance Single submitter
- COLGALT2 p.Met359Thr Uncertain significance Single submitter
- COLGALT2 p.Met529Thr Uncertain significance Single submitter
- COLGALT2 p.Phe141Ser Uncertain significance Single submitter
- COLGALT2 p.Phe270Leu Uncertain significance Single submitter
- COLGALT2 p.Pro256Leu Uncertain significance Single submitter
- COLGALT2 p.Pro554His Uncertain significance Single submitter
- COLGALT2 p.Pro621Leu Uncertain significance Single submitter
- COLGALT2 p.Ser160Ala Uncertain significance Single submitter
- COLGALT2 p.Ser403Phe Uncertain significance Single submitter
- COLGALT2 p.Ser595Phe Uncertain significance Single submitter
- COLGALT2 p.Ser603Asn Uncertain significance Single submitter
- COLGALT2 p.Thr138Asn Uncertain significance Single submitter
- COLGALT2 p.Thr227Ile Uncertain significance Single submitter
- COLGALT2 p.Thr263Ile Uncertain significance Single submitter
- COLGALT2 p.Thr615Ala Uncertain significance Single submitter
- COLGALT2 p.Trp224Arg Uncertain significance Single submitter
- COLGALT2 p.Tyr218His Uncertain significance Single submitter
- COLGALT2 p.Tyr260Cys Uncertain significance Single submitter
- COLGALT2 p.Tyr282His Uncertain significance Single submitter
- COLGALT2 p.Val219Ile Uncertain significance Single submitter
- COLGALT2 p.Val329Gly Uncertain significance Single submitter
- COLGALT2 p.Val331Gly Uncertain significance Single submitter
- COLGALT2 p.Val332Phe Uncertain significance Single submitter
- COLGALT2 p.Val535Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- COLGALT2 p.Arg427Gly Uncertain significance Single submitter
- COLGALT2 p.Arg440His Uncertain significance Single submitter
- COLGALT2 p.Asn580Ser Uncertain significance Single submitter
- COLGALT2 p.Asp217Gly Uncertain significance Single submitter
- COLGALT2 p.Gln176Pro Uncertain significance Single submitter
- COLGALT2 p.Leu14Gln Uncertain significance Single submitter
- COLGALT2 p.Pro233Ala Uncertain significance Single submitter
- COLGALT2 p.Thr154Asn Uncertain significance Single submitter
- COLGALT2 p.Thr497Ile Uncertain significance Single submitter
- COLGALT2 p.Thr98Ala Uncertain significance Single submitter
- COLGALT2 p.Trp578Arg Uncertain significance Single submitter
- COLGALT2 p.Tyr291Cys Uncertain significance Single submitter
- COLGALT2 p.Tyr418His Uncertain significance Single submitter
All COLGALT2 variants
Likely benign 3
- p.Arg600His Single submitter
- p.Phe102Leu Single submitter
- p.Tyr218= Single submitter
Uncertain significance 93
- p.Ala142Val Single submitter ⚠
- p.Ala155Val Single submitter ⚠
- p.Ala271Val Single submitter ⚠
- p.Ala584Thr Single submitter ⚠
- p.Ala7Ser Single submitter ⚠
- p.Arg148Gln Single submitter
- p.Arg222Gln Single submitter ⚠
- p.Arg244Gly Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg351Gly Single submitter ⚠
- p.Arg404Met Single submitter ⚠
- p.Arg427Gly Single submitter ⚠
- p.Arg440Cys Single submitter ⚠
- p.Arg440His Single submitter ⚠
- p.Arg470Gly Single submitter ⚠
- p.Arg589Lys Single submitter ⚠
- p.Arg596Gln Single submitter ⚠
- p.Arg596Trp Single submitter ⚠
- p.Asn382Ser Single submitter ⚠
- p.Asn514Ser Single submitter ⚠
- p.Asn580Ser Single submitter ⚠
- p.Asn63Lys Single submitter ⚠
- p.Asp217Gly Single submitter ⚠
- p.Asp399Asn Single submitter ⚠
- p.Asp426Glu Single submitter ⚠
- p.Asp492Asn Single submitter ⚠
- p.Asp579Asn Single submitter ⚠
- p.Asp586Asn Single submitter ⚠
- p.Asp618Asn Single submitter ⚠
- p.Gln149Pro Single submitter ⚠
- p.Gln176Pro Single submitter ⚠
- p.Gln508Arg Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu287Gln Single submitter ⚠
- p.Glu40Gln Single submitter ⚠
- p.Glu537Lys Single submitter ⚠
- p.Glu543Gly Single submitter ⚠
- p.Gly228Ala Single submitter
- p.Gly39Arg Single submitter ⚠
- p.Gly73Cys Single submitter ⚠
- p.His114Arg Single submitter
- p.His135Arg Single submitter ⚠
- p.His443Asp Single submitter ⚠
- p.His533Arg Single submitter ⚠
- p.His70Pro Single submitter ⚠
- p.His70Tyr Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile188Thr Single submitter ⚠
- p.Ile318Thr Single submitter ⚠
- p.Ile372Asn Single submitter ⚠
- p.Leu147Pro Single submitter ⚠
- p.Leu14Gln Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Leu50Arg Single submitter ⚠
- p.Lys387Arg Single submitter ⚠
- p.Lys431Gln Single submitter ⚠
- p.Lys448Arg Single submitter ⚠
- p.Lys451Thr Single submitter ⚠
- p.Met192Arg Single submitter ⚠
- p.Met359Thr Single submitter ⚠
- p.Met529Thr Single submitter ⚠
- p.Phe141Ser Single submitter ⚠
- p.Phe270Leu Single submitter ⚠
- p.Pro233Ala Single submitter ⚠
- p.Pro256Arg Single submitter
- p.Pro256Leu Single submitter ⚠
- p.Pro554His Single submitter ⚠
- p.Pro621Leu Single submitter ⚠
- p.Ser160Ala Single submitter ⚠
- p.Ser403Phe Single submitter ⚠
- p.Ser595Phe Single submitter ⚠
- p.Ser603Asn Single submitter ⚠
- p.Thr138Asn Single submitter ⚠
- p.Thr154Asn Single submitter ⚠
- p.Thr227Ile Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr497Ile Single submitter ⚠
- p.Thr615Ala Single submitter ⚠
- p.Thr98Ala Single submitter ⚠
- p.Trp224Arg Single submitter ⚠
- p.Trp578Arg Single submitter ⚠
- p.Tyr218His Single submitter ⚠
- p.Tyr260Cys Single submitter ⚠
- p.Tyr282His Single submitter ⚠
- p.Tyr291Cys Single submitter ⚠
- p.Tyr418His Single submitter ⚠
- p.Val219Ile Single submitter ⚠
- p.Val329Gly Single submitter ⚠
- p.Val331Gly Single submitter ⚠
- p.Val332Phe Single submitter ⚠
- p.Val482Leu Single submitter
- p.Val535Ile Single submitter ⚠