COMMD3 — 7 ClinVar variants
All ClinVar germline COMMD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
1 Likely benign · 6 Uncertain significance
Full COMMD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All COMMD3 variants
Likely benign 1
- p.Tyr163His Single submitter
Uncertain significance 6
- p.Arg120Thr Single submitter ⚠
- p.Gln135Glu Single submitter ⚠
- p.Gln194Arg Single submitter ⚠
- p.His142Gln Single submitter ⚠
- p.Val155Ala Single submitter ⚠
- p.Val179Leu Single submitter ⚠