COMMD4 — 34 ClinVar variants
All ClinVar germline COMMD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full COMMD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COMMD4 p.Ala132Thr Uncertain significance Single submitter
- COMMD4 p.Ala163Thr Uncertain significance Single submitter
- COMMD4 p.Arg127Gly Uncertain significance Single submitter
- COMMD4 p.Arg158Gln Uncertain significance Single submitter
- COMMD4 p.Asp13Glu Uncertain significance Single submitter
- COMMD4 p.Asp85Asn Uncertain significance Single submitter
- COMMD4 p.Asp8Gly Uncertain significance Single submitter
- COMMD4 p.Gly133Asp Uncertain significance Single submitter
- COMMD4 p.Leu117Ser Uncertain significance Single submitter
- COMMD4 p.Leu96Pro Uncertain significance Single submitter
- COMMD4 p.Met128Ile Uncertain significance Single submitter
- COMMD4 p.Met154Val Uncertain significance Single submitter
- COMMD4 p.Met195Arg Uncertain significance Single submitter
- COMMD4 p.Ser144Tyr Uncertain significance Single submitter
- COMMD4 p.Ser62Pro Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- COMMD4 p.Ala103Thr Uncertain significance Single submitter
- COMMD4 p.Ala103Val Uncertain significance Single submitter
- COMMD4 p.Ala191Thr Uncertain significance Single submitter
- COMMD4 p.Arg108His Uncertain significance Single submitter
- COMMD4 p.Arg122Trp Uncertain significance Single submitter
- COMMD4 p.Arg137Gln Uncertain significance Single submitter
- COMMD4 p.Gln44Arg Uncertain significance Single submitter
- COMMD4 p.Glu40Lys Uncertain significance Single submitter
- COMMD4 p.Leu52Pro Uncertain significance Single submitter
- COMMD4 p.Leu76Val Uncertain significance Single submitter
- COMMD4 p.Lys50Thr Uncertain significance Single submitter
- COMMD4 p.Pro165Ser Uncertain significance Single submitter
- COMMD4 p.Ser175Cys Uncertain significance Single submitter
- COMMD4 p.Thr21Lys Uncertain significance Single submitter
- COMMD4 p.Thr21Met Uncertain significance Single submitter
- COMMD4 p.Tyr140Cys Uncertain significance Single submitter
- COMMD4 p.Val134Met Uncertain significance Single submitter
- COMMD4 p.Val69Met Uncertain significance Single submitter
- COMMD4 p.Leu41Arg Uncertain significance No assertion criteria
All COMMD4 variants
Uncertain significance 34
- p.Ala103Thr Single submitter ⚠
- p.Ala103Val Single submitter ⚠
- p.Ala132Thr Single submitter ⚠
- p.Ala163Thr Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Arg127Gly Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Asp13Glu Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Asp8Gly Single submitter ⚠
- p.Gln44Arg Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.Gly133Asp Single submitter ⚠
- p.Leu117Ser Single submitter ⚠
- p.Leu52Pro Single submitter ⚠
- p.Leu76Val Single submitter ⚠
- p.Leu96Pro Single submitter ⚠
- p.Lys50Thr Single submitter ⚠
- p.Met128Ile Single submitter ⚠
- p.Met154Val Single submitter ⚠
- p.Met195Arg Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Ser144Tyr Single submitter ⚠
- p.Ser175Cys Single submitter ⚠
- p.Ser62Pro Single submitter ⚠
- p.Thr21Lys Single submitter ⚠
- p.Thr21Met Single submitter ⚠
- p.Tyr140Cys Single submitter ⚠
- p.Val134Met Single submitter ⚠
- p.Val69Met Single submitter ⚠
- p.Leu41Arg No assertion criteria ⚠