COMMD5 — 39 ClinVar variants
All ClinVar germline COMMD5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
4 Likely benign · 35 Uncertain significance
Full COMMD5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COMMD5 p.Ala153Thr Uncertain significance Single submitter
- COMMD5 p.Arg65Gln Uncertain significance Single submitter
- COMMD5 p.Asn76Ser Uncertain significance Single submitter
- COMMD5 p.Gly5Ala Uncertain significance Single submitter
- COMMD5 p.Ile118Leu Uncertain significance Single submitter
- COMMD5 p.Leu11Val Uncertain significance Single submitter
- COMMD5 p.Leu40Val Uncertain significance Single submitter
- COMMD5 p.Leu99Val Uncertain significance Single submitter
- COMMD5 p.Pro31Leu Uncertain significance Single submitter
- COMMD5 p.Ser164Pro Uncertain significance Single submitter
- COMMD5 p.Ser175Arg Uncertain significance Single submitter
- COMMD5 p.Tyr10His Uncertain significance Single submitter
- COMMD5 p.Val207Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- COMMD5 p.Arg135Gln Uncertain significance Single submitter
- COMMD5 p.Arg158Trp Uncertain significance Single submitter
- COMMD5 p.Arg201Gln Uncertain significance Single submitter
- COMMD5 p.Arg217Ser Uncertain significance Single submitter
- COMMD5 p.Arg220His Uncertain significance Single submitter
- COMMD5 p.Arg70His Uncertain significance Single submitter
- COMMD5 p.Asp107Asn Uncertain significance Single submitter
- COMMD5 p.Asp139Gly Uncertain significance Single submitter
- COMMD5 p.Asp184Gly Uncertain significance Single submitter
- COMMD5 p.Gln179Arg Uncertain significance Single submitter
- COMMD5 p.Glu210Lys Uncertain significance Single submitter
- COMMD5 p.Gly185Arg Uncertain significance Single submitter
- COMMD5 p.Gly61Arg Uncertain significance Single submitter
- COMMD5 p.Leu168Pro Uncertain significance Single submitter
- COMMD5 p.Leu39Pro Uncertain significance Single submitter
- COMMD5 p.Leu71His Uncertain significance Single submitter
- COMMD5 p.Met211Val Uncertain significance Single submitter
- COMMD5 p.Pro150Leu Uncertain significance Single submitter
- COMMD5 p.Ser19Asn Uncertain significance Single submitter
- COMMD5 p.Thr47Met Uncertain significance Single submitter
- COMMD5 p.Val129Met Uncertain significance Single submitter
- COMMD5 p.Val152Phe Uncertain significance Single submitter
All COMMD5 variants
Likely benign 4
- p.Arg38Gln Single submitter
- p.Gln143Arg Single submitter
- p.Met89Thr Single submitter
- p.Phe54Leu Single submitter
Uncertain significance 35
- p.Ala153Thr Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg158Trp Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg217Ser Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp139Gly Single submitter ⚠
- p.Asp184Gly Single submitter ⚠
- p.Gln179Arg Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly5Ala Single submitter ⚠
- p.Gly61Arg Single submitter ⚠
- p.Ile118Leu Single submitter ⚠
- p.Leu11Val Single submitter ⚠
- p.Leu168Pro Single submitter ⚠
- p.Leu39Pro Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Leu71His Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Met211Val Single submitter ⚠
- p.Pro150Leu Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Ser164Pro Single submitter ⚠
- p.Ser175Arg Single submitter ⚠
- p.Ser19Asn Single submitter ⚠
- p.Thr47Met Single submitter ⚠
- p.Tyr10His Single submitter ⚠
- p.Val129Met Single submitter ⚠
- p.Val152Phe Single submitter ⚠
- p.Val207Ile Single submitter ⚠