COMMD6 — 8 ClinVar variants
All ClinVar germline COMMD6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full COMMD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All COMMD6 variants
Uncertain significance 8
- p.Ala50Pro Single submitter ⚠
- p.Asp33Asn Single submitter ⚠
- p.Ile82Thr Single submitter ⚠
- p.Lys57Asn Single submitter ⚠
- p.Met28Val Single submitter ⚠
- p.Met46Ile Single submitter ⚠
- p.Phe61Ser Single submitter ⚠
- p.Val30Met Single submitter ⚠