COMMD9 — 23 ClinVar variants
All ClinVar germline COMMD9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign · 1 Likely benign · 21 Uncertain significance
Full COMMD9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COMMD9 p.Arg110Lys Uncertain significance Single submitter
- COMMD9 p.Arg66Cys Uncertain significance Single submitter
- COMMD9 p.Glu58Gln Uncertain significance Single submitter
- COMMD9 p.Gly161Ala Uncertain significance Single submitter
- COMMD9 p.Leu67Arg Uncertain significance Single submitter
- COMMD9 p.Thr68Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- COMMD9 p.Ala57Ser Uncertain significance Single submitter
- COMMD9 p.Arg122Cys Uncertain significance Single submitter
- COMMD9 p.Arg141His Uncertain significance Single submitter
- COMMD9 p.Arg187Cys Uncertain significance Single submitter
- COMMD9 p.Arg74Cys Uncertain significance Single submitter
- COMMD9 p.Asp125Asn Uncertain significance Single submitter
- COMMD9 p.Glu80Lys Uncertain significance Single submitter
- COMMD9 p.His8Leu Uncertain significance Single submitter
- COMMD9 p.Lys175Arg Uncertain significance Single submitter
- COMMD9 p.Met142Thr Uncertain significance Single submitter
- COMMD9 p.Thr46Ser Uncertain significance Single submitter
- COMMD9 p.Thr5Ala Uncertain significance Single submitter
- COMMD9 p.Val124Ile Uncertain significance Single submitter
- COMMD9 p.Val24Leu Uncertain significance Single submitter
All COMMD9 variants
Benign 1
- p.Ala79= Multiple submitters
Likely benign 1
- p.Thr108Ala Single submitter
Uncertain significance 21
- p.Ala57Ser Single submitter ⚠
- p.Arg110Lys Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Glu58Gln Single submitter ⚠
- p.Glu80Lys Single submitter ⚠
- p.Gly161Ala Single submitter ⚠
- p.His8Leu Single submitter ⚠
- p.Leu67Arg Single submitter ⚠
- p.Lys175Arg Single submitter ⚠
- p.Met142Thr Single submitter ⚠
- p.Thr46Ser Single submitter ⚠
- p.Thr5Ala Single submitter ⚠
- p.Thr68Ala Single submitter ⚠
- p.Val124Ile Single submitter ⚠
- p.Val24Leu Single submitter ⚠
- p.Leu70fs No assertion criteria