COPRS — 28 ClinVar variants
All ClinVar germline COPRS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
28 Uncertain significance
Full COPRS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COPRS p.Ala130Ser Uncertain significance Single submitter
- COPRS p.Ala13Ser Uncertain significance Single submitter
- COPRS p.Ala14Thr Uncertain significance Single submitter
- COPRS p.Ala28Thr Uncertain significance Single submitter
- COPRS p.Ala8Ser Uncertain significance Single submitter
- COPRS p.Arg46Thr Uncertain significance Single submitter
- COPRS p.Arg54Gln Uncertain significance Single submitter
- COPRS p.Arg57Cys Uncertain significance Single submitter
- COPRS p.Asn126Ser Uncertain significance Single submitter
- COPRS p.Asn64Ser Uncertain significance Single submitter
- COPRS p.Asp2Glu Uncertain significance Single submitter
- COPRS p.Gln11Pro Uncertain significance Single submitter
- COPRS p.Gln134Arg Uncertain significance Single submitter
- COPRS p.Gln134Glu Uncertain significance Single submitter
- COPRS p.Gln9His Uncertain significance Single submitter
- COPRS p.Glu106Lys Uncertain significance Single submitter
- COPRS p.Gly125Arg Uncertain significance Single submitter
- COPRS p.Gly70Ser Uncertain significance Single submitter
- COPRS p.Gly79Ala Uncertain significance Single submitter
- COPRS p.Leu111Pro Uncertain significance Single submitter
- COPRS p.Leu3Phe Uncertain significance Single submitter
- COPRS p.Pro104Ser Uncertain significance Single submitter
- COPRS p.Pro16Leu Uncertain significance Single submitter
- COPRS p.Pro23Leu Uncertain significance Single submitter
- COPRS p.Ser43Asn Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All COPRS variants
Uncertain significance 28
- p.Ala130Ser Single submitter ⚠
- p.Ala13Ser Single submitter ⚠
- p.Ala14Thr Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg46Thr Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Asn126Ser Single submitter ⚠
- p.Asn64Ser Single submitter ⚠
- p.Asp180Glu Single submitter ⚠
- p.Asp2Glu Single submitter ⚠
- p.Gln11Pro Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Gln134Glu Single submitter ⚠
- p.Gln9His Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Gly125Arg Single submitter ⚠
- p.Gly70Ser Single submitter ⚠
- p.Gly79Ala Single submitter ⚠
- p.Leu111Pro Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Ser43Asn Single submitter ⚠
- p.Trp144Cys Single submitter ⚠
- p.Trp94Arg Single submitter ⚠