COQ10A — 42 ClinVar variants
All ClinVar germline COQ10A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
42 Uncertain significance
Full COQ10A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COQ10A p.Ala148Thr Uncertain significance Single submitter
- COQ10A p.Ala62Thr Uncertain significance Single submitter
- COQ10A p.Arg224Pro Uncertain significance Single submitter
- COQ10A p.Arg8Leu Uncertain significance Single submitter
- COQ10A p.Asn82Ser Uncertain significance Single submitter
- COQ10A p.Cys187Arg Uncertain significance Single submitter
- COQ10A p.Glu196Lys Uncertain significance Single submitter
- COQ10A p.Glu222Gln Uncertain significance Single submitter
- COQ10A p.Gly28Arg Uncertain significance Single submitter
- COQ10A p.Gly36Val Uncertain significance Single submitter
- COQ10A p.Lys228Arg Uncertain significance Single submitter
- COQ10A p.Phe167Leu Uncertain significance Single submitter
- COQ10A p.Phe167Tyr Uncertain significance Single submitter
- COQ10A p.Pro139Arg Uncertain significance Single submitter
- COQ10A p.Pro31Arg Uncertain significance Single submitter
- COQ10A p.Pro33Ala Uncertain significance Single submitter
- COQ10A p.Thr13Met Uncertain significance Single submitter
- COQ10A p.Thr227Ser Uncertain significance Single submitter
- COQ10A p.Thr247Ser Uncertain significance Single submitter
- COQ10A p.Trp3Leu Uncertain significance Single submitter
- COQ10A p.Tyr87Cys Uncertain significance Single submitter
- COQ10A p.Val104Met Uncertain significance Single submitter
- COQ10A p.Val189Ala Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- COQ10A p.Ala182Val Uncertain significance Single submitter
- COQ10A p.Arg198His Uncertain significance Single submitter
- COQ10A p.Arg19Cys Uncertain significance Single submitter
- COQ10A p.Arg224Gln Uncertain significance Single submitter
- COQ10A p.Arg237His Uncertain significance Single submitter
- COQ10A p.Asn106Ser Uncertain significance Single submitter
- COQ10A p.Gln204Glu Uncertain significance Single submitter
- COQ10A p.Glu171Asp Uncertain significance Single submitter
- COQ10A p.Gly28Asp Uncertain significance Single submitter
- COQ10A p.Ile180Phe Uncertain significance Single submitter
- COQ10A p.Phe73Tyr Uncertain significance Single submitter
- COQ10A p.Pro35Ser Uncertain significance Single submitter
- COQ10A p.Pro37Leu Uncertain significance Single submitter
- COQ10A p.Ser124Phe Uncertain significance Single submitter
- COQ10A p.Ser124Tyr Uncertain significance Single submitter
- COQ10A p.Ser192Pro Uncertain significance Single submitter
- COQ10A p.Ser88Leu Uncertain significance Single submitter
- COQ10A p.Val107Ile Uncertain significance Single submitter
- COQ10A p.Val244Leu Uncertain significance Single submitter
All COQ10A variants
Uncertain significance 42
- p.Ala148Thr Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg19Cys Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg224Pro Single submitter ⚠
- p.Arg237His Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Asn106Ser Single submitter ⚠
- p.Asn82Ser Single submitter ⚠
- p.Cys187Arg Single submitter ⚠
- p.Gln204Glu Single submitter ⚠
- p.Glu171Asp Single submitter ⚠
- p.Glu196Lys Single submitter ⚠
- p.Glu222Gln Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.Gly28Asp Single submitter ⚠
- p.Gly36Val Single submitter ⚠
- p.Ile180Phe Single submitter ⚠
- p.Lys228Arg Single submitter ⚠
- p.Phe167Leu Single submitter ⚠
- p.Phe167Tyr Single submitter ⚠
- p.Phe73Tyr Single submitter ⚠
- p.Pro139Arg Single submitter ⚠
- p.Pro31Arg Single submitter ⚠
- p.Pro33Ala Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Ser124Phe Single submitter ⚠
- p.Ser124Tyr Single submitter ⚠
- p.Ser192Pro Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Thr13Met Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr247Ser Single submitter ⚠
- p.Trp3Leu Single submitter ⚠
- p.Tyr87Cys Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val189Ala Single submitter ⚠
- p.Val244Leu Single submitter ⚠