Sugi Variant

Sugi Variant/CORIN

CORIN — 224 ClinVar variants

All ClinVar germline CORIN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 175 flagged for review →

3 Pathogenic · 1 Likely pathogenic · 1 Conflicting · 8 Benign · 4 Benign/Likely benign · 31 Likely benign · 176 Uncertain significance

Full CORIN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 175

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 140

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 34

The independent predictors disagree with each other — read with care.

All CORIN variants

Pathogenic 3

Likely pathogenic 1

  • p.Ser669fs Single submitter cardiomyopathy, familial hypertrophic, 30, atrial

Conflicting classifications of pathogenicity 1

  • p.Ser4fs Single submitter preeclampsia/eclampsia 5

Benign 8

Benign/Likely benign 4

Likely benign 31

Uncertain significance 176