CPA5 — 84 ClinVar variants
All ClinVar germline CPA5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
8 Likely benign · 76 Uncertain significance
Full CPA5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPA5 p.Ala120Thr Uncertain significance Single submitter
- CPA5 p.Ala229Val Uncertain significance Single submitter
- CPA5 p.Ala350Asp Uncertain significance Single submitter
- CPA5 p.Ala393Asp Uncertain significance Single submitter
- CPA5 p.Ala393Thr Uncertain significance Single submitter
- CPA5 p.Arg10Cys Uncertain significance Single submitter
- CPA5 p.Arg198Trp Uncertain significance Single submitter
- CPA5 p.Arg19Gly Uncertain significance Single submitter
- CPA5 p.Arg75Lys Uncertain significance Single submitter
- CPA5 p.Asn281His Uncertain significance Single submitter
- CPA5 p.Asp158His Uncertain significance Single submitter
- CPA5 p.Asp241Val Uncertain significance Single submitter
- CPA5 p.Asp348Gly Uncertain significance Single submitter
- CPA5 p.Asp81Gly Uncertain significance Single submitter
- CPA5 p.Gln343His Uncertain significance Single submitter
- CPA5 p.Glu199Lys Uncertain significance Single submitter
- CPA5 p.Gly267Ser Uncertain significance Single submitter
- CPA5 p.Gly33Ser Uncertain significance Single submitter
- CPA5 p.Gly3Ala Uncertain significance Single submitter
- CPA5 p.His196Arg Uncertain significance Single submitter
- CPA5 p.Ile105Thr Uncertain significance Single submitter
- CPA5 p.Ile259Val Uncertain significance Single submitter
- CPA5 p.Ile320Thr Uncertain significance Single submitter
- CPA5 p.Ile322Thr Uncertain significance Single submitter
- CPA5 p.Ile427Val Uncertain significance Single submitter
- CPA5 p.Phe309Leu Uncertain significance Single submitter
- CPA5 p.Pro11Ser Uncertain significance Single submitter
- CPA5 p.Pro339Ser Uncertain significance Single submitter
- CPA5 p.Ser77Gly Uncertain significance Single submitter
- CPA5 p.Thr401Asn Uncertain significance Single submitter
- CPA5 p.Thr9Arg Uncertain significance Single submitter
- CPA5 p.Thr9Met Uncertain significance Single submitter
- CPA5 p.Trp274Cys Uncertain significance Single submitter
- CPA5 p.Tyr325Ser Uncertain significance Single submitter
- CPA5 p.Tyr392Asn Uncertain significance Single submitter
- CPA5 p.Val160Ala Uncertain significance Single submitter
- CPA5 p.Val382Ile Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CPA5 p.Ala188Val Uncertain significance Single submitter
- CPA5 p.Ala356Val Uncertain significance Single submitter
- CPA5 p.Ala423Val Uncertain significance Single submitter
- CPA5 p.Arg126Gln Uncertain significance Single submitter
- CPA5 p.Arg126Trp Uncertain significance Single submitter
- CPA5 p.Arg129His Uncertain significance Single submitter
- CPA5 p.Arg185Trp Uncertain significance Single submitter
- CPA5 p.Arg251His Uncertain significance Single submitter
- CPA5 p.Arg254Trp Uncertain significance Single submitter
- CPA5 p.Arg399Gln Uncertain significance Single submitter
- CPA5 p.Arg425Trp Uncertain significance Single submitter
- CPA5 p.Arg44Gln Uncertain significance Single submitter
- CPA5 p.Arg71His Uncertain significance Single submitter
- CPA5 p.Asp231Asn Uncertain significance Single submitter
- CPA5 p.Gln41His Uncertain significance Single submitter
- CPA5 p.Gly33Asp Uncertain significance Single submitter
- CPA5 p.His293Asp Uncertain significance Single submitter
- CPA5 p.His430Gln Uncertain significance Single submitter
- CPA5 p.Ile165Met Uncertain significance Single submitter
- CPA5 p.Ile201Leu Uncertain significance Single submitter
- CPA5 p.Ile234Thr Uncertain significance Single submitter
- CPA5 p.Leu59Gln Uncertain significance Single submitter
- CPA5 p.Leu78Pro Uncertain significance Single submitter
- CPA5 p.Lys351Asn Uncertain significance Single submitter
- CPA5 p.Lys351Met Uncertain significance Single submitter
- CPA5 p.Met106Thr Uncertain significance Single submitter
- CPA5 p.Met328Ile Uncertain significance Single submitter
- CPA5 p.Phe169Leu Uncertain significance Single submitter
- CPA5 p.Pro187Ser Uncertain significance Single submitter
- CPA5 p.Pro261Leu Uncertain significance Single submitter
- CPA5 p.Pro287Ser Uncertain significance Single submitter
- CPA5 p.Ser147Gly Uncertain significance Single submitter
- CPA5 p.Ser173Phe Uncertain significance Single submitter
- CPA5 p.Ser299Leu Uncertain significance Single submitter
- CPA5 p.Ser388Gly Uncertain significance Single submitter
- CPA5 p.Thr373Ile Uncertain significance Single submitter
- CPA5 p.Tyr358Cys Uncertain significance Single submitter
- CPA5 p.Tyr386His Uncertain significance Single submitter
- CPA5 p.Val84Ile Uncertain significance Single submitter
All CPA5 variants
Likely benign 8
- p.Arg185Gln Single submitter
- p.Ile266= Single submitter
- p.Leu32Trp Single submitter
- p.Pro409= Single submitter
- p.Thr416= Single submitter
- p.Thr420= Single submitter
- p.Val16Met Single submitter
- p.Val382= Single submitter
Uncertain significance 76
- p.Ala120Thr Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala229Val Single submitter ⚠
- p.Ala350Asp Single submitter ⚠
- p.Ala356Val Single submitter ⚠
- p.Ala393Asp Single submitter ⚠
- p.Ala393Thr Single submitter ⚠
- p.Ala423Val Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg185Trp Single submitter ⚠
- p.Arg198Trp Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg425Trp Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Arg75Lys Single submitter ⚠
- p.Asn281His Single submitter ⚠
- p.Asp158His Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Asp241Val Single submitter ⚠
- p.Asp348Gly Single submitter ⚠
- p.Asp81Gly Single submitter ⚠
- p.Gln343His Single submitter ⚠
- p.Gln41His Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Gly267Ser Single submitter ⚠
- p.Gly33Asp Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.His196Arg Single submitter ⚠
- p.His293Asp Single submitter ⚠
- p.His430Gln Single submitter ⚠
- p.Ile105Thr Single submitter ⚠
- p.Ile165Met Single submitter ⚠
- p.Ile201Leu Single submitter ⚠
- p.Ile234Thr Single submitter ⚠
- p.Ile259Val Single submitter ⚠
- p.Ile320Thr Single submitter ⚠
- p.Ile322Thr Single submitter ⚠
- p.Ile427Val Single submitter ⚠
- p.Leu59Gln Single submitter ⚠
- p.Leu78Pro Single submitter ⚠
- p.Lys351Asn Single submitter ⚠
- p.Lys351Met Single submitter ⚠
- p.Met106Thr Single submitter ⚠
- p.Met328Ile Single submitter ⚠
- p.Phe169Leu Single submitter ⚠
- p.Phe309Leu Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro261Leu Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro339Ser Single submitter ⚠
- p.Ser147Gly Single submitter ⚠
- p.Ser173Phe Single submitter ⚠
- p.Ser299Leu Single submitter ⚠
- p.Ser388Gly Single submitter ⚠
- p.Ser77Gly Single submitter ⚠
- p.Thr373Ile Single submitter ⚠
- p.Thr401Asn Single submitter ⚠
- p.Thr9Arg Single submitter ⚠
- p.Thr9Met Single submitter ⚠
- p.Trp274Cys Single submitter ⚠
- p.Tyr325Ser Single submitter ⚠
- p.Tyr358Cys Single submitter ⚠
- p.Tyr386His Single submitter ⚠
- p.Tyr392Asn Single submitter ⚠
- p.Val160Ala Single submitter ⚠
- p.Val382Ile Single submitter ⚠
- p.Val84Ile Single submitter ⚠