Sugi Variant

Sugi Variant/CPE

CPE — 156 ClinVar variants

All ClinVar germline CPE variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →

7 Pathogenic · 1 Likely pathogenic · 9 Benign · 3 Benign/Likely benign · 56 Likely benign · 80 Uncertain significance

Full CPE gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 84

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 38

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 46

The independent predictors disagree with each other — read with care.

All CPE variants

Pathogenic 7

Likely pathogenic 1

Benign 9

Benign/Likely benign 3

Likely benign 56

Uncertain significance 80