CPEB4 — 55 ClinVar variants
All ClinVar germline CPEB4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
55 Uncertain significance
Full CPEB4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPEB4 p.Ala104Ser Uncertain significance Single submitter
- CPEB4 p.Ala197Pro Uncertain significance Single submitter
- CPEB4 p.Ala349Ser Uncertain significance Single submitter
- CPEB4 p.Ala610Thr Uncertain significance Single submitter
- CPEB4 p.Ala80Thr Uncertain significance Single submitter
- CPEB4 p.Arg134Lys Uncertain significance Single submitter
- CPEB4 p.Arg319Lys Uncertain significance Single submitter
- CPEB4 p.Arg350Cys Uncertain significance Single submitter
- CPEB4 p.Arg444Cys Uncertain significance Single submitter
- CPEB4 p.Arg472Gln Uncertain significance Single submitter
- CPEB4 p.Arg674His Uncertain significance Single submitter
- CPEB4 p.Arg704His Uncertain significance Single submitter
- CPEB4 p.Asn122Ser Uncertain significance Single submitter
- CPEB4 p.Asn16Lys Uncertain significance Single submitter
- CPEB4 p.Asn341Ser Uncertain significance Single submitter
- CPEB4 p.Asn36His Uncertain significance Single submitter
- CPEB4 p.Asn52Ser Uncertain significance Single submitter
- CPEB4 p.Asp369Glu Uncertain significance Single submitter
- CPEB4 p.Asp413Asn Uncertain significance Single submitter
- CPEB4 p.Asp652Tyr Uncertain significance Single submitter
- CPEB4 p.Cys670Ser Uncertain significance Single submitter
- CPEB4 p.Gln156His Uncertain significance Single submitter
- CPEB4 p.Gln192Pro Uncertain significance Single submitter
- CPEB4 p.Gln346His Uncertain significance Single submitter
- CPEB4 p.Gln429His Uncertain significance Single submitter
- CPEB4 p.Glu125Gln Uncertain significance Single submitter
- CPEB4 p.Glu185Asp Uncertain significance Single submitter
- CPEB4 p.Gly452Val Uncertain significance Single submitter
- CPEB4 p.Ile325Val Uncertain significance Single submitter
- CPEB4 p.Ile343Thr Uncertain significance Single submitter
- CPEB4 p.Ile532Asn Uncertain significance Single submitter
- CPEB4 p.Leu662Trp Uncertain significance Single submitter
- CPEB4 p.Pro157His Uncertain significance Single submitter
- CPEB4 p.Pro234Leu Uncertain significance Single submitter
- CPEB4 p.Pro375Leu Uncertain significance Single submitter
- CPEB4 p.Pro39His Uncertain significance Single submitter
- CPEB4 p.Pro434Ala Uncertain significance Single submitter
- CPEB4 p.Pro65Ser Uncertain significance Single submitter
- CPEB4 p.Ser160Pro Uncertain significance Single submitter
- CPEB4 p.Ser163Trp Uncertain significance Single submitter
- CPEB4 p.Ser340Gly Uncertain significance Single submitter
- CPEB4 p.Tyr306Cys Uncertain significance Single submitter
- CPEB4 p.Val195Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CPEB4 p.Arg493His Uncertain significance Single submitter
- CPEB4 p.Asp533Glu Uncertain significance Single submitter
- CPEB4 p.Gly5Arg Uncertain significance Single submitter
- CPEB4 p.His213Tyr Uncertain significance Single submitter
- CPEB4 p.His25Arg Uncertain significance Single submitter
- CPEB4 p.Ile582Val Uncertain significance Single submitter
- CPEB4 p.Leu274Trp Uncertain significance Single submitter
- CPEB4 p.Phe210Leu Uncertain significance Single submitter
- CPEB4 p.Phe459Val Uncertain significance Single submitter
- CPEB4 p.Pro237Ala Uncertain significance Single submitter
- CPEB4 p.Ser123Pro Uncertain significance Single submitter
- CPEB4 p.Ser215Asn Uncertain significance Single submitter
All CPEB4 variants
Uncertain significance 55
- p.Ala104Ser Single submitter ⚠
- p.Ala197Pro Single submitter ⚠
- p.Ala349Ser Single submitter ⚠
- p.Ala610Thr Single submitter ⚠
- p.Ala80Thr Single submitter ⚠
- p.Arg134Lys Single submitter ⚠
- p.Arg319Lys Single submitter ⚠
- p.Arg350Cys Single submitter ⚠
- p.Arg444Cys Single submitter ⚠
- p.Arg472Gln Single submitter ⚠
- p.Arg493His Single submitter ⚠
- p.Arg674His Single submitter ⚠
- p.Arg704His Single submitter ⚠
- p.Asn122Ser Single submitter ⚠
- p.Asn16Lys Single submitter ⚠
- p.Asn341Ser Single submitter ⚠
- p.Asn36His Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Asp413Asn Single submitter ⚠
- p.Asp533Glu Single submitter ⚠
- p.Asp652Tyr Single submitter ⚠
- p.Cys670Ser Single submitter ⚠
- p.Gln156His Single submitter ⚠
- p.Gln192Pro Single submitter ⚠
- p.Gln346His Single submitter ⚠
- p.Gln429His Single submitter ⚠
- p.Glu125Gln Single submitter ⚠
- p.Glu185Asp Single submitter ⚠
- p.Gly452Val Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.His25Arg Single submitter ⚠
- p.Ile325Val Single submitter ⚠
- p.Ile343Thr Single submitter ⚠
- p.Ile532Asn Single submitter ⚠
- p.Ile582Val Single submitter ⚠
- p.Leu274Trp Single submitter ⚠
- p.Leu662Trp Single submitter ⚠
- p.Phe210Leu Single submitter ⚠
- p.Phe459Val Single submitter ⚠
- p.Pro157His Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro237Ala Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro39His Single submitter ⚠
- p.Pro434Ala Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Ser123Pro Single submitter ⚠
- p.Ser160Pro Single submitter ⚠
- p.Ser163Trp Single submitter ⚠
- p.Ser215Asn Single submitter ⚠
- p.Ser340Gly Single submitter ⚠
- p.Tyr306Cys Single submitter ⚠
- p.Val195Ala Single submitter ⚠