CPLX2 — 8 ClinVar variants
All ClinVar germline CPLX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full CPLX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All CPLX2 variants
Uncertain significance 8
- p.Ala103Val Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Glu58Gly Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly21Glu Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Lys134Glu Single submitter ⚠
- p.Pro102Ser Single submitter ⚠