CPNE3 — 67 ClinVar variants
All ClinVar germline CPNE3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
2 Likely benign · 65 Uncertain significance
Full CPNE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPNE3 p.Asn302Ser Uncertain significance Multiple submitters
- CPNE3 p.Ala239Pro Uncertain significance Single submitter
- CPNE3 p.Ala349Thr Uncertain significance Single submitter
- CPNE3 p.Ala3Val Uncertain significance Single submitter
- CPNE3 p.Ala408Thr Uncertain significance Single submitter
- CPNE3 p.Arg113Gln Uncertain significance Single submitter
- CPNE3 p.Arg179Trp Uncertain significance Single submitter
- CPNE3 p.Arg406Lys Uncertain significance Single submitter
- CPNE3 p.Arg47Cys Uncertain significance Single submitter
- CPNE3 p.Arg47His Uncertain significance Single submitter
- CPNE3 p.Asp154Tyr Uncertain significance Single submitter
- CPNE3 p.Asp224Asn Uncertain significance Single submitter
- CPNE3 p.Asp335Tyr Uncertain significance Single submitter
- CPNE3 p.Asp468Asn Uncertain significance Single submitter
- CPNE3 p.Cys98Tyr Uncertain significance Single submitter
- CPNE3 p.Gln534Lys Uncertain significance Single submitter
- CPNE3 p.Gln537Arg Uncertain significance Single submitter
- CPNE3 p.Gly221Arg Uncertain significance Single submitter
- CPNE3 p.His223Leu Uncertain significance Single submitter
- CPNE3 p.His359Arg Uncertain significance Single submitter
- CPNE3 p.Ile226Thr Uncertain significance Single submitter
- CPNE3 p.Ile87Thr Uncertain significance Single submitter
- CPNE3 p.Ile87Val Uncertain significance Single submitter
- CPNE3 p.Lys153Glu Uncertain significance Single submitter
- CPNE3 p.Lys258Glu Uncertain significance Single submitter
- CPNE3 p.Met363Val Uncertain significance Single submitter
- CPNE3 p.Pro477Ser Uncertain significance Single submitter
- CPNE3 p.Pro499Ser Uncertain significance Single submitter
- CPNE3 p.Pro57Thr Uncertain significance Single submitter
- CPNE3 p.Ser107Pro Uncertain significance Single submitter
- CPNE3 p.Ser127Arg Uncertain significance Single submitter
- CPNE3 p.Trp191Leu Uncertain significance Single submitter
- CPNE3 p.Tyr261Cys Uncertain significance Single submitter
- CPNE3 p.Tyr67Asp Uncertain significance Single submitter
- CPNE3 p.Val319Ile Uncertain significance Single submitter
- CPNE3 p.Val32Met Uncertain significance Single submitter
- CPNE3 p.Val6Asp Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CPNE3 p.Ala409Thr Uncertain significance Single submitter
- CPNE3 p.Arg179Gln Uncertain significance Single submitter
- CPNE3 p.Arg406Gly Uncertain significance Single submitter
- CPNE3 p.Arg446Gly Uncertain significance Single submitter
- CPNE3 p.Asn17Ser Uncertain significance Single submitter
- CPNE3 p.Asn317Ser Uncertain significance Single submitter
- CPNE3 p.Gln439Leu Uncertain significance Single submitter
- CPNE3 p.Gln58Arg Uncertain significance Single submitter
- CPNE3 p.Glu238Val Uncertain significance Single submitter
- CPNE3 p.Glu465Gly Uncertain significance Single submitter
- CPNE3 p.Gly120Val Uncertain significance Single submitter
- CPNE3 p.Gly24Arg Uncertain significance Single submitter
- CPNE3 p.Leu18Ile Uncertain significance Single submitter
- CPNE3 p.Leu326Phe Uncertain significance Single submitter
- CPNE3 p.Lys149Arg Uncertain significance Single submitter
- CPNE3 p.Met341Val Uncertain significance Single submitter
- CPNE3 p.Phe143Leu Uncertain significance Single submitter
- CPNE3 p.Phe34Leu Uncertain significance Single submitter
- CPNE3 p.Pro193Leu Uncertain significance Single submitter
- CPNE3 p.Pro367Gln Uncertain significance Single submitter
- CPNE3 p.Pro367Leu Uncertain significance Single submitter
- CPNE3 p.Pro399Ala Uncertain significance Single submitter
- CPNE3 p.Ser307Phe Uncertain significance Single submitter
- CPNE3 p.Thr228Ile Uncertain significance Single submitter
- CPNE3 p.Thr62Ile Uncertain significance Single submitter
- CPNE3 p.Trp355Arg Uncertain significance Single submitter
- CPNE3 p.Trp355Cys Uncertain significance Single submitter
- CPNE3 p.Val430Met Uncertain significance Single submitter
All CPNE3 variants
Likely benign 2
- p.Asp470= Single submitter
- p.Ile351Val Single submitter
Uncertain significance 65
- p.Asn302Ser Multiple submitters ⚠
- p.Ala239Pro Single submitter ⚠
- p.Ala349Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala408Thr Single submitter ⚠
- p.Ala409Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg179Trp Single submitter ⚠
- p.Arg406Gly Single submitter ⚠
- p.Arg406Lys Single submitter ⚠
- p.Arg446Gly Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Asn17Ser Single submitter ⚠
- p.Asn317Ser Single submitter ⚠
- p.Asp154Tyr Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Asp335Tyr Single submitter ⚠
- p.Asp468Asn Single submitter ⚠
- p.Cys98Tyr Single submitter ⚠
- p.Gln439Leu Single submitter ⚠
- p.Gln534Lys Single submitter ⚠
- p.Gln537Arg Single submitter ⚠
- p.Gln58Arg Single submitter ⚠
- p.Glu238Val Single submitter ⚠
- p.Glu465Gly Single submitter ⚠
- p.Gly120Val Single submitter ⚠
- p.Gly221Arg Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.His223Leu Single submitter ⚠
- p.His359Arg Single submitter ⚠
- p.Ile226Thr Single submitter ⚠
- p.Ile87Thr Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu18Ile Single submitter ⚠
- p.Leu326Phe Single submitter ⚠
- p.Lys149Arg Single submitter ⚠
- p.Lys153Glu Single submitter ⚠
- p.Lys258Glu Single submitter ⚠
- p.Met341Val Single submitter ⚠
- p.Met363Val Single submitter ⚠
- p.Phe143Leu Single submitter ⚠
- p.Phe34Leu Single submitter ⚠
- p.Pro193Leu Single submitter ⚠
- p.Pro367Gln Single submitter ⚠
- p.Pro367Leu Single submitter ⚠
- p.Pro399Ala Single submitter ⚠
- p.Pro477Ser Single submitter ⚠
- p.Pro499Ser Single submitter ⚠
- p.Pro57Thr Single submitter ⚠
- p.Ser107Pro Single submitter ⚠
- p.Ser127Arg Single submitter ⚠
- p.Ser307Phe Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Trp191Leu Single submitter ⚠
- p.Trp355Arg Single submitter ⚠
- p.Trp355Cys Single submitter ⚠
- p.Tyr261Cys Single submitter ⚠
- p.Tyr67Asp Single submitter ⚠
- p.Val319Ile Single submitter ⚠
- p.Val32Met Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Val6Asp Single submitter ⚠