CPNE9 — 65 ClinVar variants
All ClinVar germline CPNE9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
65 Uncertain significance
Full CPNE9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPNE9 p.Arg147Trp Uncertain significance Single submitter
- CPNE9 p.Arg228Trp Uncertain significance Single submitter
- CPNE9 p.Arg261Gln Uncertain significance Single submitter
- CPNE9 p.Arg69Ser Uncertain significance Single submitter
- CPNE9 p.Arg9Gly Uncertain significance Single submitter
- CPNE9 p.Arg9His Uncertain significance Single submitter
- CPNE9 p.Asn212Asp Uncertain significance Single submitter
- CPNE9 p.Asp163Glu Uncertain significance Single submitter
- CPNE9 p.Asp27Gly Uncertain significance Single submitter
- CPNE9 p.Asp347Asn Uncertain significance Single submitter
- CPNE9 p.Asp438Ala Uncertain significance Single submitter
- CPNE9 p.Cys133Tyr Uncertain significance Single submitter
- CPNE9 p.Cys155Arg Uncertain significance Single submitter
- CPNE9 p.Gln552Lys Uncertain significance Single submitter
- CPNE9 p.Glu523Gly Uncertain significance Single submitter
- CPNE9 p.Glu551Gln Uncertain significance Single submitter
- CPNE9 p.Glu8Gly Uncertain significance Single submitter
- CPNE9 p.Ile235Thr Uncertain significance Single submitter
- CPNE9 p.Ile304Thr Uncertain significance Single submitter
- CPNE9 p.Ile383Thr Uncertain significance Single submitter
- CPNE9 p.Leu258Val Uncertain significance Single submitter
- CPNE9 p.Leu25Gln Uncertain significance Single submitter
- CPNE9 p.Lys33Asn Uncertain significance Single submitter
- CPNE9 p.Lys98Thr Uncertain significance Single submitter
- CPNE9 p.Met469Ile Uncertain significance Single submitter
- CPNE9 p.Phe171Val Uncertain significance Single submitter
- CPNE9 p.Pro522Leu Uncertain significance Single submitter
- CPNE9 p.Ser97Pro Uncertain significance Single submitter
- CPNE9 p.Thr287Ile Uncertain significance Single submitter
- CPNE9 p.Thr56Ala Uncertain significance Single submitter
- CPNE9 p.Val113Gly Uncertain significance Single submitter
- CPNE9 p.Val479Leu Uncertain significance Single submitter
- CPNE9 p.Val494Phe Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- CPNE9 p.Arg123Gln Uncertain significance Single submitter
- CPNE9 p.Arg364Trp Uncertain significance Single submitter
- CPNE9 p.Arg395His Uncertain significance Single submitter
- CPNE9 p.Arg478His Uncertain significance Single submitter
- CPNE9 p.Arg484Cys Uncertain significance Single submitter
- CPNE9 p.Arg512Gln Uncertain significance Single submitter
- CPNE9 p.Arg537Gln Uncertain significance Single submitter
- CPNE9 p.Asn197Ser Uncertain significance Single submitter
- CPNE9 p.Asp27Glu Uncertain significance Single submitter
- CPNE9 p.Gly127Ala Uncertain significance Single submitter
- CPNE9 p.Gly130Ala Uncertain significance Single submitter
- CPNE9 p.Gly474Ser Uncertain significance Single submitter
- CPNE9 p.Ile114Thr Uncertain significance Single submitter
- CPNE9 p.Leu137Trp Uncertain significance Single submitter
- CPNE9 p.Leu278Val Uncertain significance Single submitter
- CPNE9 p.Leu508Phe Uncertain significance Single submitter
- CPNE9 p.Pro12Arg Uncertain significance Single submitter
- CPNE9 p.Pro12Leu Uncertain significance Single submitter
- CPNE9 p.Pro538Leu Uncertain significance Single submitter
- CPNE9 p.Pro539Ser Uncertain significance Single submitter
- CPNE9 p.Pro544Ala Uncertain significance Single submitter
- CPNE9 p.Ser2Pro Uncertain significance Single submitter
- CPNE9 p.Ser448Arg Uncertain significance Single submitter
- CPNE9 p.Thr218Met Uncertain significance Single submitter
- CPNE9 p.Thr30Ile Uncertain significance Single submitter
- CPNE9 p.Thr531Ile Uncertain significance Single submitter
- CPNE9 p.Tyr325Phe Uncertain significance Single submitter
- CPNE9 p.Tyr485Asn Uncertain significance Single submitter
- CPNE9 p.Val192Met Uncertain significance Single submitter
- CPNE9 p.Val412Ala Uncertain significance Single submitter
- CPNE9 p.Val447Ile Uncertain significance Single submitter
- CPNE9 p.Val491Ile Uncertain significance Single submitter
All CPNE9 variants
Uncertain significance 65
- p.Arg123Gln Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg228Trp Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg364Trp Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg484Cys Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg537Gln Single submitter ⚠
- p.Arg69Ser Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn197Ser Single submitter ⚠
- p.Asn212Asp Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp27Glu Single submitter ⚠
- p.Asp27Gly Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp438Ala Single submitter ⚠
- p.Cys133Tyr Single submitter ⚠
- p.Cys155Arg Single submitter ⚠
- p.Gln552Lys Single submitter ⚠
- p.Glu523Gly Single submitter ⚠
- p.Glu551Gln Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly127Ala Single submitter ⚠
- p.Gly130Ala Single submitter ⚠
- p.Gly474Ser Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile235Thr Single submitter ⚠
- p.Ile304Thr Single submitter ⚠
- p.Ile383Thr Single submitter ⚠
- p.Leu137Trp Single submitter ⚠
- p.Leu258Val Single submitter ⚠
- p.Leu25Gln Single submitter ⚠
- p.Leu278Val Single submitter ⚠
- p.Leu508Phe Single submitter ⚠
- p.Lys33Asn Single submitter ⚠
- p.Lys98Thr Single submitter ⚠
- p.Met469Ile Single submitter ⚠
- p.Phe171Val Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro539Ser Single submitter ⚠
- p.Pro544Ala Single submitter ⚠
- p.Ser2Pro Single submitter ⚠
- p.Ser448Arg Single submitter ⚠
- p.Ser97Pro Single submitter ⚠
- p.Thr218Met Single submitter ⚠
- p.Thr287Ile Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr531Ile Single submitter ⚠
- p.Thr56Ala Single submitter ⚠
- p.Tyr325Phe Single submitter ⚠
- p.Tyr485Asn Single submitter ⚠
- p.Val113Gly Single submitter ⚠
- p.Val192Met Single submitter ⚠
- p.Val412Ala Single submitter ⚠
- p.Val447Ile Single submitter ⚠
- p.Val479Leu Single submitter ⚠
- p.Val491Ile Single submitter ⚠
- p.Val494Phe Single submitter ⚠