CPO — 56 ClinVar variants
All ClinVar germline CPO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
4 Likely benign · 52 Uncertain significance
Full CPO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPO p.Ala109Thr Uncertain significance Single submitter
- CPO p.Ala289Ser Uncertain significance Single submitter
- CPO p.Arg299Gln Uncertain significance Single submitter
- CPO p.Asn183His Uncertain significance Single submitter
- CPO p.Asn187Asp Uncertain significance Single submitter
- CPO p.Asn255Thr Uncertain significance Single submitter
- CPO p.Asp227Asn Uncertain significance Single submitter
- CPO p.Asp22Ala Uncertain significance Single submitter
- CPO p.Gly154Asp Uncertain significance Single submitter
- CPO p.His129Arg Uncertain significance Single submitter
- CPO p.Ile156Ser Uncertain significance Single submitter
- CPO p.Ile49Val Uncertain significance Single submitter
- CPO p.Leu126Pro Uncertain significance Single submitter
- CPO p.Leu270Ser Uncertain significance Single submitter
- CPO p.Lys137Thr Uncertain significance Single submitter
- CPO p.Lys35Asn Uncertain significance Single submitter
- CPO p.Met13Leu Uncertain significance Single submitter
- CPO p.Met371Leu Uncertain significance Single submitter
- CPO p.Phe144Ser Uncertain significance Single submitter
- CPO p.Pro39Ala Uncertain significance Single submitter
- CPO p.Ser133Thr Uncertain significance Single submitter
- CPO p.Trp112Gly Uncertain significance Single submitter
- CPO p.Tyr278Ser Uncertain significance Single submitter
- CPO p.Val122Leu Uncertain significance Single submitter
- CPO p.Val33Ala Uncertain significance Single submitter
- CPO p.Val37Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CPO p.Arg136Cys Uncertain significance Single submitter
- CPO p.Arg136His Likely benign Single submitter
- CPO p.Arg169Cys Uncertain significance Single submitter
- CPO p.Asp131His Uncertain significance Single submitter
- CPO p.Glu323Lys Uncertain significance Single submitter
- CPO p.Glu332Asp Uncertain significance Single submitter
- CPO p.Glu43Gly Uncertain significance Single submitter
- CPO p.Gly275Glu Uncertain significance Single submitter
- CPO p.Gly365Asp Uncertain significance Single submitter
- CPO p.His51Tyr Uncertain significance Single submitter
- CPO p.Ile222Thr Uncertain significance Single submitter
- CPO p.Ile326Val Uncertain significance Single submitter
- CPO p.Leu139Arg Uncertain significance Single submitter
- CPO p.Leu139Phe Uncertain significance Single submitter
- CPO p.Leu363Gln Uncertain significance Single submitter
- CPO p.Leu5Val Uncertain significance Single submitter
- CPO p.Lys99Asn Uncertain significance Single submitter
- CPO p.Pro171Ser Likely benign Single submitter
- CPO p.Pro93Leu Uncertain significance Single submitter
- CPO p.Pro97Leu Uncertain significance Single submitter
- CPO p.Ser224Arg Uncertain significance Single submitter
- CPO p.Ser291Pro Uncertain significance Single submitter
- CPO p.Ser353Cys Uncertain significance Single submitter
- CPO p.Ser41Arg Uncertain significance Single submitter
- CPO p.Thr158Ala Uncertain significance Single submitter
- CPO p.Thr316Ile Uncertain significance Single submitter
- CPO p.Thr44Met Uncertain significance Single submitter
- CPO p.Val320Phe Uncertain significance Single submitter
All CPO variants
Likely benign 4
- p.Arg136His Single submitter ⚠
- p.His108= Single submitter
- p.Pro171Ser Single submitter ⚠
- p.Thr44= Single submitter
Uncertain significance 52
- p.Ala109Thr Single submitter ⚠
- p.Ala289Ser Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Asn183His Single submitter ⚠
- p.Asn187Asp Single submitter ⚠
- p.Asn255Thr Single submitter ⚠
- p.Asp131His Single submitter ⚠
- p.Asp227Asn Single submitter ⚠
- p.Asp22Ala Single submitter ⚠
- p.Glu323Lys Single submitter ⚠
- p.Glu332Asp Single submitter ⚠
- p.Glu43Gly Single submitter ⚠
- p.Gly154Asp Single submitter ⚠
- p.Gly275Glu Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.His129Arg Single submitter ⚠
- p.His51Tyr Single submitter ⚠
- p.Ile156Ser Single submitter ⚠
- p.Ile222Thr Single submitter ⚠
- p.Ile326Val Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Leu139Arg Single submitter ⚠
- p.Leu139Phe Single submitter ⚠
- p.Leu270Ser Single submitter ⚠
- p.Leu363Gln Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Lys137Thr Single submitter ⚠
- p.Lys35Asn Single submitter ⚠
- p.Lys99Asn Single submitter ⚠
- p.Met13Leu Single submitter ⚠
- p.Met371Leu Single submitter ⚠
- p.Phe144Ser Single submitter ⚠
- p.Pro39Ala Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser133Thr Single submitter ⚠
- p.Ser224Arg Single submitter ⚠
- p.Ser291Pro Single submitter ⚠
- p.Ser353Cys Single submitter ⚠
- p.Ser41Arg Single submitter ⚠
- p.Thr158Ala Single submitter ⚠
- p.Thr316Ile Single submitter ⚠
- p.Thr44Met Single submitter ⚠
- p.Trp112Gly Single submitter ⚠
- p.Tyr278Ser Single submitter ⚠
- p.Val122Leu Single submitter ⚠
- p.Val320Phe Single submitter ⚠
- p.Val33Ala Single submitter ⚠
- p.Val37Leu Single submitter ⚠