CPSF7 — 54 ClinVar variants
All ClinVar germline CPSF7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
54 Uncertain significance
Full CPSF7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPSF7 p.Arg173Trp Uncertain significance Single submitter
- CPSF7 p.Arg56His Uncertain significance Single submitter
- CPSF7 p.Arg78His Uncertain significance Single submitter
- CPSF7 p.Asn151His Uncertain significance Single submitter
- CPSF7 p.Asn198Lys Uncertain significance Single submitter
- CPSF7 p.Asn217Ser Uncertain significance Single submitter
- CPSF7 p.Asp43Val Uncertain significance Single submitter
- CPSF7 p.Glu395Asp Uncertain significance Single submitter
- CPSF7 p.Gly295Ala Uncertain significance Single submitter
- CPSF7 p.Gly312Val Uncertain significance Single submitter
- CPSF7 p.His256Asn Uncertain significance Single submitter
- CPSF7 p.Ile105Val Uncertain significance Single submitter
- CPSF7 p.Ile10Thr Uncertain significance Single submitter
- CPSF7 p.Ile366Leu Uncertain significance Single submitter
- CPSF7 p.Leu199Phe Uncertain significance Single submitter
- CPSF7 p.Leu199Pro Uncertain significance Single submitter
- CPSF7 p.Leu223Ile Uncertain significance Single submitter
- CPSF7 p.Leu280Val Uncertain significance Single submitter
- CPSF7 p.Ser242Gly Uncertain significance Single submitter
- CPSF7 p.Ser46Arg Uncertain significance Single submitter
- CPSF7 p.Ser48Arg Uncertain significance Single submitter
- CPSF7 p.Ser48Thr Uncertain significance Single submitter
- CPSF7 p.Thr194Ala Uncertain significance Single submitter
- CPSF7 p.Thr67Asn Uncertain significance Single submitter
- CPSF7 p.Thr67Pro Uncertain significance Single submitter
- CPSF7 p.Val149Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CPSF7 p.Arg205Cys Uncertain significance Single submitter
- CPSF7 p.Arg381His Uncertain significance Single submitter
- CPSF7 p.Arg413Leu Uncertain significance Single submitter
- CPSF7 p.Arg417Trp Uncertain significance Single submitter
- CPSF7 p.Arg78Cys Uncertain significance Single submitter
- CPSF7 p.Asp455Gly Uncertain significance Single submitter
- CPSF7 p.Asp455Val Uncertain significance Single submitter
- CPSF7 p.Gly4Glu Uncertain significance Single submitter
- CPSF7 p.Ile384Leu Uncertain significance Single submitter
- CPSF7 p.Leu144Phe Uncertain significance Single submitter
- CPSF7 p.Pro210His Uncertain significance Single submitter
- CPSF7 p.Pro229His Uncertain significance Single submitter
- CPSF7 p.Pro237Leu Uncertain significance Single submitter
- CPSF7 p.Pro250Ser Uncertain significance Single submitter
- CPSF7 p.Pro289Ala Uncertain significance Single submitter
- CPSF7 p.Pro296Ser Uncertain significance Single submitter
- CPSF7 p.Ser75Arg Uncertain significance Single submitter
- CPSF7 p.Tyr74Cys Uncertain significance Single submitter
All CPSF7 variants
Uncertain significance 54
- c.-15C>T Single submitter
- c.-21C>G Single submitter
- c.-56+117C>T Single submitter
- c.-56+123C>G Single submitter
- c.-56+124C>T Single submitter
- c.-56+133G>C Single submitter
- c.-56+138G>C Single submitter
- c.-56+150C>T Single submitter
- c.-56+153G>C Single submitter
- p.Arg173Trp Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg413Leu Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Arg78His Single submitter ⚠
- p.Asn151His Single submitter ⚠
- p.Asn198Lys Single submitter ⚠
- p.Asn217Ser Single submitter ⚠
- p.Asp43Val Single submitter ⚠
- p.Asp455Gly Single submitter ⚠
- p.Asp455Val Single submitter ⚠
- p.Glu395Asp Single submitter ⚠
- p.Gly295Ala Single submitter ⚠
- p.Gly312Val Single submitter ⚠
- p.Gly4Glu Single submitter ⚠
- p.His256Asn Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile10Thr Single submitter ⚠
- p.Ile366Leu Single submitter ⚠
- p.Ile384Leu Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu199Phe Single submitter ⚠
- p.Leu199Pro Single submitter ⚠
- p.Leu223Ile Single submitter ⚠
- p.Leu280Val Single submitter ⚠
- p.Pro210His Single submitter ⚠
- p.Pro229His Single submitter ⚠
- p.Pro237Leu Single submitter ⚠
- p.Pro250Ser Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Pro296Ser Single submitter ⚠
- p.Ser242Gly Single submitter ⚠
- p.Ser46Arg Single submitter ⚠
- p.Ser48Arg Single submitter ⚠
- p.Ser48Thr Single submitter ⚠
- p.Ser75Arg Single submitter ⚠
- p.Thr194Ala Single submitter ⚠
- p.Thr67Asn Single submitter ⚠
- p.Thr67Pro Single submitter ⚠
- p.Tyr74Cys Single submitter ⚠
- p.Val149Ala Single submitter ⚠
- c.523+2dup No assertion criteria prostate cancer