CPTP — 56 ClinVar variants
All ClinVar germline CPTP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
9 Likely benign · 47 Uncertain significance
Full CPTP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPTP p.Ala132Thr Uncertain significance Single submitter
- CPTP p.Arg106Trp Uncertain significance Single submitter
- CPTP p.Arg133Cys Uncertain significance Single submitter
- CPTP p.Arg155Pro Uncertain significance Single submitter
- CPTP p.Arg168Cys Uncertain significance Single submitter
- CPTP p.Arg66His Uncertain significance Single submitter
- CPTP p.Arg97His Uncertain significance Single submitter
- CPTP p.Glu130Lys Uncertain significance Single submitter
- CPTP p.Glu86Lys Uncertain significance Single submitter
- CPTP p.Gly178Arg Uncertain significance Single submitter
- CPTP p.His100Asp Uncertain significance Single submitter
- CPTP p.His112Tyr Uncertain significance Single submitter
- CPTP p.His99Tyr Uncertain significance Single submitter
- CPTP p.Leu14Pro Uncertain significance Single submitter
- CPTP p.Leu67Phe Uncertain significance Single submitter
- CPTP p.Met82Ile Uncertain significance Single submitter
- CPTP p.Pro166Leu Uncertain significance Single submitter
- CPTP p.Pro166Ser Uncertain significance Single submitter
- CPTP p.Val184Met Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CPTP p.Arg106Gln Uncertain significance Single submitter
- CPTP p.Arg110Cys Uncertain significance Single submitter
- CPTP p.Arg110His Uncertain significance Single submitter
- CPTP p.Arg126Cys Uncertain significance Single submitter
- CPTP p.Arg155His Uncertain significance Single submitter
- CPTP p.Arg156His Uncertain significance Single submitter
- CPTP p.Arg196Cys Uncertain significance Single submitter
- CPTP p.Arg196His Likely benign Single submitter
- CPTP p.Arg62Trp Uncertain significance Single submitter
- CPTP p.Arg68Trp Uncertain significance Single submitter
- CPTP p.Arg77His Uncertain significance Single submitter
- CPTP p.Cys20Arg Uncertain significance Single submitter
- CPTP p.Gln195His Uncertain significance Single submitter
- CPTP p.Glu26Lys Uncertain significance Single submitter
- CPTP p.Glu74Lys Uncertain significance Single submitter
- CPTP p.Gly124Ser Uncertain significance Single submitter
- CPTP p.His85Gln Uncertain significance Single submitter
- CPTP p.Ile33Val Uncertain significance Single submitter
- CPTP p.Leu115Val Uncertain significance Single submitter
- CPTP p.Pro179Thr Uncertain significance Single submitter
- CPTP p.Pro180Gln Uncertain significance Single submitter
- CPTP p.Pro31Ser Uncertain significance Single submitter
- CPTP p.Ser103Thr Uncertain significance Single submitter
- CPTP p.Ser145Leu Uncertain significance Single submitter
- CPTP p.Ser35Thr Uncertain significance Single submitter
- CPTP p.Thr164Met Uncertain significance Single submitter
- CPTP p.Tyr76His Uncertain significance Single submitter
- CPTP p.Val158Ile Uncertain significance Single submitter
All CPTP variants
Likely benign 9
- p.Ala136Thr Single submitter
- p.Ala139Thr Single submitter
- p.Arg196His Single submitter ⚠
- p.Arg62Gln Single submitter
- p.Arg77Ser Single submitter
- p.Arg90Gln Single submitter
- p.His85Tyr Single submitter
- p.Ser4Leu Single submitter
- p.Val153= Single submitter
Uncertain significance 47
- p.Ala132Thr Single submitter ⚠
- p.Arg106Gln Single submitter ⚠
- p.Arg106Trp Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg155Pro Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Cys20Arg Single submitter ⚠
- p.Gln195His Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu65Ter Single submitter
- p.Glu74Lys Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.His100Asp Single submitter ⚠
- p.His112Tyr Single submitter ⚠
- p.His85Gln Single submitter ⚠
- p.His99Tyr Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu14Pro Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Met82Ile Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro179Thr Single submitter ⚠
- p.Pro180Gln Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Ser103Thr Single submitter ⚠
- p.Ser145Leu Single submitter ⚠
- p.Ser35Thr Single submitter ⚠
- p.Thr164Met Single submitter ⚠
- p.Tyr76His Single submitter ⚠
- p.Val158Ile Single submitter ⚠
- p.Val184Met Single submitter ⚠