CPXM1 — 111 ClinVar variants
All ClinVar germline CPXM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
2 Benign · 12 Likely benign · 97 Uncertain significance
Full CPXM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPXM1 p.Ala108Thr Uncertain significance Single submitter
- CPXM1 p.Ala227Thr Uncertain significance Single submitter
- CPXM1 p.Ala269Pro Uncertain significance Single submitter
- CPXM1 p.Ala288Val Uncertain significance Single submitter
- CPXM1 p.Ala53Val Uncertain significance Single submitter
- CPXM1 p.Arg124Gln Uncertain significance Single submitter
- CPXM1 p.Arg146Trp Uncertain significance Single submitter
- CPXM1 p.Arg268Gln Uncertain significance Single submitter
- CPXM1 p.Arg268Trp Uncertain significance Single submitter
- CPXM1 p.Arg367Trp Uncertain significance Single submitter
- CPXM1 p.Arg396Cys Uncertain significance Single submitter
- CPXM1 p.Arg396Leu Uncertain significance Single submitter
- CPXM1 p.Arg488Gln Uncertain significance Single submitter
- CPXM1 p.Arg488Leu Uncertain significance Single submitter
- CPXM1 p.Arg518His Uncertain significance Single submitter
- CPXM1 p.Arg518Leu Uncertain significance Single submitter
- CPXM1 p.Arg530Ser Uncertain significance Single submitter
- CPXM1 p.Arg549Gln Uncertain significance Single submitter
- CPXM1 p.Arg549Leu Uncertain significance Single submitter
- CPXM1 p.Arg65Gln Uncertain significance Single submitter
- CPXM1 p.Arg662His Uncertain significance Single submitter
- CPXM1 p.Arg686Gln Uncertain significance Single submitter
- CPXM1 p.Arg686Pro Uncertain significance Single submitter
- CPXM1 p.Asn301Ser Uncertain significance Single submitter
- CPXM1 p.Asp127Ala Uncertain significance Single submitter
- CPXM1 p.Asp509Asn Uncertain significance Single submitter
- CPXM1 p.Asp633Gly Uncertain significance Single submitter
- CPXM1 p.Gln544Arg Uncertain significance Single submitter
- CPXM1 p.Glu352Gly Uncertain significance Single submitter
- CPXM1 p.Glu519Lys Uncertain significance Single submitter
- CPXM1 p.Gly161Glu Uncertain significance Single submitter
- CPXM1 p.Gly290Val Uncertain significance Single submitter
- CPXM1 p.Gly358Asp Uncertain significance Single submitter
- CPXM1 p.Gly560Ser Uncertain significance Single submitter
- CPXM1 p.Gly565Arg Uncertain significance Single submitter
- CPXM1 p.His180Tyr Uncertain significance Single submitter
- CPXM1 p.His299Arg Uncertain significance Single submitter
- CPXM1 p.His460Arg Uncertain significance Single submitter
- CPXM1 p.His650Arg Uncertain significance Single submitter
- CPXM1 p.Ile643Thr Uncertain significance Single submitter
- CPXM1 p.Ile643Val Uncertain significance Single submitter
- CPXM1 p.Lys205Asn Uncertain significance Single submitter
- CPXM1 p.Met76Thr Uncertain significance Single submitter
- CPXM1 p.Pro13Ser Uncertain significance Single submitter
- CPXM1 p.Pro256Ser Uncertain significance Single submitter
- CPXM1 p.Pro32Thr Uncertain significance Single submitter
- CPXM1 p.Pro401Leu Uncertain significance Single submitter
- CPXM1 p.Pro52Arg Uncertain significance Single submitter
- CPXM1 p.Ser40Ala Uncertain significance Single submitter
- CPXM1 p.Thr701Ser Uncertain significance Single submitter
- CPXM1 p.Trp445Cys Uncertain significance Single submitter
- CPXM1 p.Val312Ala Uncertain significance Single submitter
- CPXM1 p.Val645Met Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- CPXM1 p.Arg725His Uncertain significance Multiple submitters
- CPXM1 p.Ala132Thr Uncertain significance Single submitter
- CPXM1 p.Ala21Pro Uncertain significance Single submitter
- CPXM1 p.Ala273Thr Uncertain significance Single submitter
- CPXM1 p.Ala537Val Uncertain significance Single submitter
- CPXM1 p.Arg129Trp Uncertain significance Single submitter
- CPXM1 p.Arg250Gly Uncertain significance Single submitter
- CPXM1 p.Arg321Cys Uncertain significance Single submitter
- CPXM1 p.Arg321His Uncertain significance Single submitter
- CPXM1 p.Arg387Trp Uncertain significance Single submitter
- CPXM1 p.Arg396His Uncertain significance Single submitter
- CPXM1 p.Arg425His Uncertain significance Single submitter
- CPXM1 p.Arg548His Uncertain significance Single submitter
- CPXM1 p.Arg622Cys Uncertain significance Single submitter
- CPXM1 p.Arg67Gly Uncertain significance Single submitter
- CPXM1 p.Arg683Trp Uncertain significance Single submitter
- CPXM1 p.Arg686Trp Uncertain significance Single submitter
- CPXM1 p.Arg709Cys Uncertain significance Single submitter
- CPXM1 p.Arg709His Uncertain significance Single submitter
- CPXM1 p.Arg728Trp Uncertain significance Single submitter
- CPXM1 p.Asn459Lys Uncertain significance Single submitter
- CPXM1 p.Asp526Asn Uncertain significance Single submitter
- CPXM1 p.Glu423Lys Uncertain significance Single submitter
- CPXM1 p.Gly384Glu Uncertain significance Single submitter
- CPXM1 p.Leu708Pro Uncertain significance Single submitter
- CPXM1 p.Leu711Pro Uncertain significance Single submitter
- CPXM1 p.Lys303Glu Uncertain significance Single submitter
- CPXM1 p.Met305Val Uncertain significance Single submitter
- CPXM1 p.Pro477Ala Uncertain significance Single submitter
- CPXM1 p.Ser393Tyr Uncertain significance Single submitter
- CPXM1 p.Ser402Cys Uncertain significance Single submitter
- CPXM1 p.Ser402Thr Uncertain significance Single submitter
- CPXM1 p.Thr189Ala Uncertain significance Single submitter
- CPXM1 p.Thr237Ala Uncertain significance Single submitter
- CPXM1 p.Thr34Ile Uncertain significance Single submitter
- CPXM1 p.Thr41Asn Uncertain significance Single submitter
- CPXM1 p.Thr570Met Uncertain significance Single submitter
- CPXM1 p.Thr634Met Uncertain significance Single submitter
- CPXM1 p.Thr634Ser Uncertain significance Single submitter
- CPXM1 p.Val228Ile Uncertain significance Single submitter
- CPXM1 p.Val353Met Uncertain significance Single submitter
- CPXM1 p.Val558Met Likely benign Single submitter
- CPXM1 p.Val699Met Uncertain significance Single submitter
- CPXM1 p.Val74Ala Uncertain significance Single submitter
- CPXM1 p.Val97Met Uncertain significance Single submitter
All CPXM1 variants
Likely benign 12
- p.Arg129Gln Single submitter
- p.Arg213Gln Single submitter
- p.Asn301Asp Single submitter
- p.Asn684Ser Single submitter
- p.Asp106Asn Single submitter
- p.His45Arg Single submitter
- p.Leu44Pro Single submitter
- p.Pro17Leu Single submitter
- p.Ser289Leu Single submitter
- p.Val558Leu Single submitter
- p.Val558Met Single submitter ⚠
- p.Ser185= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 97
- p.Arg725His Multiple submitters ⚠
- p.Ala108Thr Single submitter ⚠
- p.Ala132Thr Single submitter ⚠
- p.Ala21Pro Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala269Pro Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala537Val Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg129Trp Single submitter ⚠
- p.Arg146Trp Single submitter ⚠
- p.Arg250Gly Single submitter ⚠
- p.Arg268Gln Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg367Trp Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg396His Single submitter ⚠
- p.Arg396Leu Single submitter ⚠
- p.Arg425His Single submitter ⚠
- p.Arg488Gln Single submitter ⚠
- p.Arg488Leu Single submitter ⚠
- p.Arg518His Single submitter ⚠
- p.Arg518Leu Single submitter ⚠
- p.Arg530Ser Single submitter ⚠
- p.Arg548His Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg549Leu Single submitter ⚠
- p.Arg622Cys Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg662His Single submitter ⚠
- p.Arg67Gly Single submitter ⚠
- p.Arg683Trp Single submitter ⚠
- p.Arg686Gln Single submitter ⚠
- p.Arg686Pro Single submitter ⚠
- p.Arg686Trp Single submitter ⚠
- p.Arg709Cys Single submitter ⚠
- p.Arg709His Single submitter ⚠
- p.Arg728Trp Single submitter ⚠
- p.Asn301Ser Single submitter ⚠
- p.Asn459Lys Single submitter ⚠
- p.Asp127Ala Single submitter ⚠
- p.Asp509Asn Single submitter ⚠
- p.Asp526Asn Single submitter ⚠
- p.Asp633Gly Single submitter ⚠
- p.Gln544Arg Single submitter ⚠
- p.Glu352Gly Single submitter ⚠
- p.Glu423Lys Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.Gly161Glu Single submitter ⚠
- p.Gly290Val Single submitter ⚠
- p.Gly358Asp Single submitter ⚠
- p.Gly384Glu Single submitter ⚠
- p.Gly560Ser Single submitter ⚠
- p.Gly565Arg Single submitter ⚠
- p.His180Tyr Single submitter ⚠
- p.His299Arg Single submitter ⚠
- p.His460Arg Single submitter ⚠
- p.His650Arg Single submitter ⚠
- p.Ile643Thr Single submitter ⚠
- p.Ile643Val Single submitter ⚠
- p.Leu708Pro Single submitter ⚠
- p.Leu711Pro Single submitter ⚠
- p.Lys205Asn Single submitter ⚠
- p.Lys303Glu Single submitter ⚠
- p.Met305Val Single submitter ⚠
- p.Met76Thr Single submitter ⚠
- p.Pro13Ser Single submitter ⚠
- p.Pro256Ser Single submitter ⚠
- p.Pro32Thr Single submitter ⚠
- p.Pro401Leu Single submitter ⚠
- p.Pro477Ala Single submitter ⚠
- p.Pro52Arg Single submitter ⚠
- p.Ser393Tyr Single submitter ⚠
- p.Ser402Cys Single submitter ⚠
- p.Ser402Thr Single submitter ⚠
- p.Ser40Ala Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr237Ala Single submitter ⚠
- p.Thr34Ile Single submitter ⚠
- p.Thr41Asn Single submitter ⚠
- p.Thr570Met Single submitter ⚠
- p.Thr634Met Single submitter ⚠
- p.Thr634Ser Single submitter ⚠
- p.Thr701Ser Single submitter ⚠
- p.Trp445Cys Single submitter ⚠
- p.Val228Ile Single submitter ⚠
- p.Val312Ala Single submitter ⚠
- p.Val353Met Single submitter ⚠
- p.Val645Met Single submitter ⚠
- p.Val699Met Single submitter ⚠
- p.Val74Ala Single submitter ⚠
- p.Val97Met Single submitter ⚠