CPXM2 — 150 ClinVar variants
All ClinVar germline CPXM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 143 flagged for review →
3 Benign · 4 Likely benign · 143 Uncertain significance
Full CPXM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 143
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPXM2 p.Ala153Asp Uncertain significance Single submitter
- CPXM2 p.Ala183Val Uncertain significance Single submitter
- CPXM2 p.Ala376Val Uncertain significance Single submitter
- CPXM2 p.Ala524Ser Uncertain significance Single submitter
- CPXM2 p.Ala591Val Uncertain significance Single submitter
- CPXM2 p.Arg165Gln Uncertain significance Single submitter
- CPXM2 p.Arg165Gly Uncertain significance Single submitter
- CPXM2 p.Arg167Thr Uncertain significance Single submitter
- CPXM2 p.Arg200Gln Uncertain significance Single submitter
- CPXM2 p.Arg272His Uncertain significance Single submitter
- CPXM2 p.Arg304Cys Uncertain significance Single submitter
- CPXM2 p.Arg444Cys Uncertain significance Single submitter
- CPXM2 p.Arg49Leu Uncertain significance Single submitter
- CPXM2 p.Arg630Trp Uncertain significance Single submitter
- CPXM2 p.Arg642Cys Uncertain significance Single submitter
- CPXM2 p.Arg671Gln Uncertain significance Single submitter
- CPXM2 p.Arg680His Uncertain significance Single submitter
- CPXM2 p.Arg72Pro Uncertain significance Single submitter
- CPXM2 p.Arg744Pro Uncertain significance Single submitter
- CPXM2 p.Arg748Gln Uncertain significance Single submitter
- CPXM2 p.Asn120Asp Uncertain significance Single submitter
- CPXM2 p.Asn214Ser Uncertain significance Single submitter
- CPXM2 p.Asn460Asp Uncertain significance Single submitter
- CPXM2 p.Asp32Gly Uncertain significance Single submitter
- CPXM2 p.Asp425His Uncertain significance Single submitter
- CPXM2 p.Asp425Val Uncertain significance Single submitter
- CPXM2 p.Asp544Asn Uncertain significance Single submitter
- CPXM2 p.Cys335Phe Uncertain significance Single submitter
- CPXM2 p.Cys604Tyr Uncertain significance Single submitter
- CPXM2 p.Gln517Pro Uncertain significance Single submitter
- CPXM2 p.Glu31Ala Uncertain significance Single submitter
- CPXM2 p.Glu371Lys Uncertain significance Single submitter
- CPXM2 p.Glu44Ala Uncertain significance Single submitter
- CPXM2 p.Glu51Gly Uncertain significance Single submitter
- CPXM2 p.Glu520Lys Uncertain significance Single submitter
- CPXM2 p.Glu92Lys Uncertain significance Single submitter
- CPXM2 p.Gly187Glu Uncertain significance Single submitter
- CPXM2 p.Gly37Arg Uncertain significance Single submitter
- CPXM2 p.Gly385Val Uncertain significance Single submitter
- CPXM2 p.Gly443Arg Uncertain significance Single submitter
- CPXM2 p.Gly443Val Uncertain significance Single submitter
- CPXM2 p.Gly643Asp Uncertain significance Single submitter
- CPXM2 p.Gly66Arg Uncertain significance Single submitter
- CPXM2 p.His152Leu Uncertain significance Single submitter
- CPXM2 p.His365Pro Uncertain significance Single submitter
- CPXM2 p.His652Arg Uncertain significance Single submitter
- CPXM2 p.Ile247Val Uncertain significance Single submitter
- CPXM2 p.Ile256Met Uncertain significance Single submitter
- CPXM2 p.Ile452Met Uncertain significance Single submitter
- CPXM2 p.Ile609Thr Uncertain significance Single submitter
- CPXM2 p.Ile609Val Uncertain significance Single submitter
- CPXM2 p.Leu291Pro Uncertain significance Single submitter
- CPXM2 p.Leu351Pro Uncertain significance Single submitter
- CPXM2 p.Leu390Arg Uncertain significance Single submitter
- CPXM2 p.Lys113Arg Uncertain significance Single submitter
- CPXM2 p.Lys732Arg Uncertain significance Single submitter
- CPXM2 p.Lys80Arg Uncertain significance Single submitter
- CPXM2 p.Lys86Arg Uncertain significance Single submitter
- CPXM2 p.Lys86Gln Uncertain significance Single submitter
- CPXM2 p.Met110Ile Uncertain significance Single submitter
- CPXM2 p.Met562Val Uncertain significance Single submitter
- CPXM2 p.Met704Val Uncertain significance Single submitter
- CPXM2 p.Met723Ile Uncertain significance Single submitter
- CPXM2 p.Met723Thr Uncertain significance Single submitter
- CPXM2 p.Phe279Ser Uncertain significance Single submitter
- CPXM2 p.Phe372Ser Uncertain significance Single submitter
- CPXM2 p.Phe510Cys Uncertain significance Single submitter
- CPXM2 p.Phe57Leu Uncertain significance Single submitter
- CPXM2 p.Pro33Arg Uncertain significance Single submitter
- CPXM2 p.Pro33Leu Uncertain significance Single submitter
- CPXM2 p.Pro370His Uncertain significance Single submitter
- CPXM2 p.Pro59Leu Uncertain significance Single submitter
- CPXM2 p.Ser347Asn Uncertain significance Single submitter
- CPXM2 p.Ser554Phe Uncertain significance Single submitter
- CPXM2 p.Thr461Met Uncertain significance Single submitter
- CPXM2 p.Thr540Ala Uncertain significance Single submitter
- CPXM2 p.Trp41Gly Uncertain significance Single submitter
- CPXM2 p.Trp626Cys Uncertain significance Single submitter
- CPXM2 p.Tyr301Cys Uncertain significance Single submitter
- CPXM2 p.Tyr374His Uncertain significance Single submitter
- CPXM2 p.Tyr555His Uncertain significance Single submitter
- CPXM2 p.Tyr610Cys Uncertain significance Single submitter
- CPXM2 p.Val109Leu Uncertain significance Single submitter
- CPXM2 p.Val23Leu Uncertain significance Single submitter
- CPXM2 p.Val264Phe Uncertain significance Single submitter
- CPXM2 p.Val367Leu Uncertain significance Single submitter
- CPXM2 p.Val663Ile Uncertain significance Single submitter
-
CPXM2 p.Gly166Glu
Uncertain significance
No assertion criteria
breast ductal adenocarcinoma
Predictors split 55
The independent predictors disagree with each other — read with care.
- CPXM2 p.Ala402Val Uncertain significance Single submitter
- CPXM2 p.Ala565Asp Uncertain significance Single submitter
- CPXM2 p.Arg158Cys Uncertain significance Single submitter
- CPXM2 p.Arg158His Uncertain significance Single submitter
- CPXM2 p.Arg158Leu Uncertain significance Single submitter
- CPXM2 p.Arg201Cys Uncertain significance Single submitter
- CPXM2 p.Arg201His Uncertain significance Single submitter
- CPXM2 p.Arg269His Uncertain significance Single submitter
- CPXM2 p.Arg305Trp Uncertain significance Single submitter
- CPXM2 p.Arg386Gln Uncertain significance Single submitter
- CPXM2 p.Arg403Trp Uncertain significance Single submitter
- CPXM2 p.Arg531Trp Uncertain significance Single submitter
- CPXM2 p.Arg549Cys Uncertain significance Single submitter
- CPXM2 p.Arg549His Uncertain significance Single submitter
- CPXM2 p.Arg560Cys Uncertain significance Single submitter
- CPXM2 p.Arg560Ser Uncertain significance Single submitter
- CPXM2 p.Arg566Trp Uncertain significance Single submitter
- CPXM2 p.Arg71Trp Uncertain significance Single submitter
- CPXM2 p.Arg744Gln Uncertain significance Single submitter
- CPXM2 p.Arg744Trp Uncertain significance Single submitter
- CPXM2 p.Arg755His Uncertain significance Single submitter
- CPXM2 p.Asn214Lys Uncertain significance Single submitter
- CPXM2 p.Asn332Ser Uncertain significance Single submitter
- CPXM2 p.Asn337Asp Uncertain significance Single submitter
- CPXM2 p.Asn381Ser Uncertain significance Single submitter
- CPXM2 p.Asn478Asp Uncertain significance Single submitter
- CPXM2 p.Asn491Ser Uncertain significance Single submitter
- CPXM2 p.Asn583Ser Uncertain significance Single submitter
- CPXM2 p.Asp468Tyr Uncertain significance Single submitter
- CPXM2 p.Asp545Asn Uncertain significance Single submitter
- CPXM2 p.Gln394Arg Uncertain significance Single submitter
- CPXM2 p.Glu307Lys Uncertain significance Single submitter
- CPXM2 p.Glu538Gly Uncertain significance Single submitter
- CPXM2 p.Gly242Arg Uncertain significance Single submitter
- CPXM2 p.Gly665Ser Uncertain significance Single submitter
- CPXM2 p.Gly665Val Uncertain significance Single submitter
- CPXM2 p.Gly695Val Uncertain significance Single submitter
- CPXM2 p.Gly706Asp Uncertain significance Single submitter
- CPXM2 p.His164Arg Uncertain significance Single submitter
- CPXM2 p.Leu151Phe Uncertain significance Single submitter
- CPXM2 p.Leu262Val Uncertain significance Single submitter
- CPXM2 p.Met286Ile Uncertain significance Single submitter
- CPXM2 p.Pro265Arg Uncertain significance Single submitter
- CPXM2 p.Thr155Met Uncertain significance Single submitter
- CPXM2 p.Thr602Ala Uncertain significance Single submitter
- CPXM2 p.Tyr180His Uncertain significance Single submitter
- CPXM2 p.Tyr354Phe Uncertain significance Single submitter
- CPXM2 p.Tyr480Cys Uncertain significance Single submitter
- CPXM2 p.Tyr555Phe Uncertain significance Single submitter
- CPXM2 p.Val229Met Uncertain significance Single submitter
- CPXM2 p.Val239Ala Uncertain significance Single submitter
- CPXM2 p.Val408Ile Uncertain significance Single submitter
- CPXM2 p.Val547Met Uncertain significance Single submitter
- CPXM2 p.Val590Ile Uncertain significance Single submitter
- CPXM2 p.Val640Ile Uncertain significance Single submitter
All CPXM2 variants
Benign 3
- c.1918-10T>C Multiple submitters
- p.Ala172= Multiple submitters
- p.Lys577Arg Multiple submitters
Likely benign 4
- p.Arg129His Single submitter
- p.Arg204Lys Single submitter
- p.Arg469Gln Single submitter
- p.Val418Ile Single submitter
Uncertain significance 143
- p.Ala153Asp Single submitter ⚠
- p.Ala183Val Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Ala402Val Single submitter ⚠
- p.Ala524Ser Single submitter ⚠
- p.Ala565Asp Single submitter ⚠
- p.Ala591Val Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg158Leu Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg165Gly Single submitter ⚠
- p.Arg167Thr Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg201Cys Single submitter ⚠
- p.Arg201His Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg305Trp Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg403Trp Single submitter ⚠
- p.Arg444Cys Single submitter ⚠
- p.Arg49Leu Single submitter ⚠
- p.Arg531Trp Single submitter ⚠
- p.Arg549Cys Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg560Cys Single submitter ⚠
- p.Arg560Ser Single submitter ⚠
- p.Arg566Trp Single submitter ⚠
- p.Arg630Trp Single submitter ⚠
- p.Arg642Cys Single submitter ⚠
- p.Arg671Gln Single submitter ⚠
- p.Arg680His Single submitter ⚠
- p.Arg71Trp Single submitter ⚠
- p.Arg72Pro Single submitter ⚠
- p.Arg744Gln Single submitter ⚠
- p.Arg744Pro Single submitter ⚠
- p.Arg744Trp Single submitter ⚠
- p.Arg748Gln Single submitter ⚠
- p.Arg755His Single submitter ⚠
- p.Asn120Asp Single submitter ⚠
- p.Asn214Lys Single submitter ⚠
- p.Asn214Ser Single submitter ⚠
- p.Asn332Ser Single submitter ⚠
- p.Asn337Asp Single submitter ⚠
- p.Asn381Ser Single submitter ⚠
- p.Asn460Asp Single submitter ⚠
- p.Asn478Asp Single submitter ⚠
- p.Asn491Ser Single submitter ⚠
- p.Asn583Ser Single submitter ⚠
- p.Asp32Gly Single submitter ⚠
- p.Asp425His Single submitter ⚠
- p.Asp425Val Single submitter ⚠
- p.Asp468Tyr Single submitter ⚠
- p.Asp544Asn Single submitter ⚠
- p.Asp545Asn Single submitter ⚠
- p.Cys335Phe Single submitter ⚠
- p.Cys604Tyr Single submitter ⚠
- p.Gln394Arg Single submitter ⚠
- p.Gln517Pro Single submitter ⚠
- p.Glu307Lys Single submitter ⚠
- p.Glu31Ala Single submitter ⚠
- p.Glu371Lys Single submitter ⚠
- p.Glu44Ala Single submitter ⚠
- p.Glu51Gly Single submitter ⚠
- p.Glu520Lys Single submitter ⚠
- p.Glu538Gly Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly187Glu Single submitter ⚠
- p.Gly242Arg Single submitter ⚠
- p.Gly37Arg Single submitter ⚠
- p.Gly385Val Single submitter ⚠
- p.Gly443Arg Single submitter ⚠
- p.Gly443Val Single submitter ⚠
- p.Gly643Asp Single submitter ⚠
- p.Gly665Ser Single submitter ⚠
- p.Gly665Val Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.Gly695Val Single submitter ⚠
- p.Gly706Asp Single submitter ⚠
- p.His152Leu Single submitter ⚠
- p.His164Arg Single submitter ⚠
- p.His365Pro Single submitter ⚠
- p.His652Arg Single submitter ⚠
- p.Ile247Val Single submitter ⚠
- p.Ile256Met Single submitter ⚠
- p.Ile452Met Single submitter ⚠
- p.Ile609Thr Single submitter ⚠
- p.Ile609Val Single submitter ⚠
- p.Leu151Phe Single submitter ⚠
- p.Leu262Val Single submitter ⚠
- p.Leu291Pro Single submitter ⚠
- p.Leu351Pro Single submitter ⚠
- p.Leu390Arg Single submitter ⚠
- p.Lys113Arg Single submitter ⚠
- p.Lys732Arg Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Lys86Arg Single submitter ⚠
- p.Lys86Gln Single submitter ⚠
- p.Met110Ile Single submitter ⚠
- p.Met286Ile Single submitter ⚠
- p.Met562Val Single submitter ⚠
- p.Met704Val Single submitter ⚠
- p.Met723Ile Single submitter ⚠
- p.Met723Thr Single submitter ⚠
- p.Phe279Ser Single submitter ⚠
- p.Phe372Ser Single submitter ⚠
- p.Phe510Cys Single submitter ⚠
- p.Phe57Leu Single submitter ⚠
- p.Pro265Arg Single submitter ⚠
- p.Pro33Arg Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro370His Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Ser347Asn Single submitter ⚠
- p.Ser554Phe Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Thr461Met Single submitter ⚠
- p.Thr540Ala Single submitter ⚠
- p.Thr602Ala Single submitter ⚠
- p.Trp41Gly Single submitter ⚠
- p.Trp626Cys Single submitter ⚠
- p.Tyr180His Single submitter ⚠
- p.Tyr301Cys Single submitter ⚠
- p.Tyr354Phe Single submitter ⚠
- p.Tyr374His Single submitter ⚠
- p.Tyr480Cys Single submitter ⚠
- p.Tyr555His Single submitter ⚠
- p.Tyr555Phe Single submitter ⚠
- p.Tyr610Cys Single submitter ⚠
- p.Val109Leu Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val239Ala Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val264Phe Single submitter ⚠
- p.Val367Leu Single submitter ⚠
- p.Val408Ile Single submitter ⚠
- p.Val547Met Single submitter ⚠
- p.Val590Ile Single submitter ⚠
- p.Val640Ile Single submitter ⚠
- p.Val663Ile Single submitter ⚠
- p.Gly166Glu No assertion criteria breast ductal adenocarcinoma ⚠