CR1 — 284 ClinVar variants
All ClinVar germline CR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 171 flagged for review →
5 Conflicting · 8 Benign · 41 Likely benign · 230 Uncertain significance
Full CR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 171
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
- CR1 p.Ile1327Val Conflicting Single submitter
-
CR1 p.Met1884Ile
Conflicting
Single submitter
KNOPS BLOOD GROUP SYSTEM
Predictors lean, ClinVar uncertain 164
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 164
-
CR1 p.Arg1208Cys
Uncertain significance
Multiple submitters
KNOPS BLOOD GROUP SYSTEM
- CR1 p.Arg2014Gln Uncertain significance Multiple submitters
- CR1 p.Ala1249Val Uncertain significance Single submitter
- CR1 p.Ala1502Thr Uncertain significance Single submitter
- CR1 p.Ala1579Thr Uncertain significance Single submitter
- CR1 p.Ala1685Ser Uncertain significance Single submitter
- CR1 p.Ala1685Val Uncertain significance Single submitter
- CR1 p.Ala1730Thr Uncertain significance Single submitter
- CR1 p.Ala1961Pro Uncertain significance Single submitter
- CR1 p.Ala2139Val Uncertain significance Single submitter
- CR1 p.Ala2297Gly Uncertain significance Single submitter
- CR1 p.Ala2404Glu Uncertain significance Single submitter
- CR1 p.Ala350Val Uncertain significance Single submitter
- CR1 p.Ala623Val Uncertain significance Single submitter
- CR1 p.Arg1239His Uncertain significance Single submitter
- CR1 p.Arg1269Cys Uncertain significance Single submitter
- CR1 p.Arg1369His Uncertain significance Single submitter
- CR1 p.Arg1386His Uncertain significance Single submitter
- CR1 p.Arg1627Cys Uncertain significance Single submitter
- CR1 p.Arg1627His Uncertain significance Single submitter
- CR1 p.Arg1819Cys Uncertain significance Single submitter
- CR1 p.Arg1842Gly Uncertain significance Single submitter
- CR1 p.Arg1842His Uncertain significance Single submitter
- CR1 p.Arg1903Lys Uncertain significance Single submitter
- CR1 p.Arg194Cys Uncertain significance Single submitter
- CR1 p.Arg194Ser Uncertain significance Single submitter
- CR1 p.Arg1985Lys Uncertain significance Single submitter
- CR1 p.Arg2014Trp Uncertain significance Single submitter
- CR1 p.Arg2088Ser Uncertain significance Single submitter
- CR1 p.Arg2172His Uncertain significance Single submitter
- CR1 p.Arg2272Cys Uncertain significance Single submitter
- CR1 p.Arg2272His Uncertain significance Single submitter
- CR1 p.Arg2289Leu Uncertain significance Single submitter
- CR1 p.Arg277His Uncertain significance Single submitter
- CR1 p.Asn1267Ser Uncertain significance Single submitter
- CR1 p.Asn1811Ser Uncertain significance Single submitter
- CR1 p.Asn2055Asp Uncertain significance Single submitter
- CR1 p.Asn2213Ser Uncertain significance Single submitter
- CR1 p.Asn2226Asp Uncertain significance Single submitter
- CR1 p.Asn375Tyr Uncertain significance Single submitter
- CR1 p.Asp1214Tyr Uncertain significance Single submitter
- CR1 p.Asp1351Asn Uncertain significance Single submitter
- CR1 p.Asp1361Asn Uncertain significance Single submitter
- CR1 p.Asp1526Asn Uncertain significance Single submitter
- CR1 p.Asp1569Gly Uncertain significance Single submitter
- CR1 p.Asp2023Gly Uncertain significance Single submitter
- CR1 p.Asp2134Tyr Uncertain significance Single submitter
- CR1 p.Asp2162Val Uncertain significance Single submitter
- CR1 p.Asp2190Glu Uncertain significance Single submitter
- CR1 p.Asp2242Gly Uncertain significance Single submitter
- CR1 p.Asp2258Asn Uncertain significance Single submitter
- CR1 p.Asp2406Tyr Uncertain significance Single submitter
- CR1 p.Asp2409Tyr Uncertain significance Single submitter
- CR1 p.Asp2421His Uncertain significance Single submitter
- CR1 p.Asp360Tyr Uncertain significance Single submitter
- CR1 p.Asp383Asn Uncertain significance Single submitter
- CR1 p.Cys1516Arg Uncertain significance Single submitter
- CR1 p.Cys1750Trp Uncertain significance Single submitter
- CR1 p.Cys2156Ser Uncertain significance Single submitter
- CR1 p.Cys2341Ser Uncertain significance Single submitter
- CR1 p.Cys73Phe Uncertain significance Single submitter
- CR1 p.Gln1851Arg Uncertain significance Single submitter
- CR1 p.Gln2167His Uncertain significance Single submitter
- CR1 p.Gln2349Pro Uncertain significance Single submitter
- CR1 p.Glu1306Lys Uncertain significance Single submitter
- CR1 p.Glu2191Asp Uncertain significance Single submitter
- CR1 p.Glu2371Gly Uncertain significance Single submitter
- CR1 p.Glu263Ala Uncertain significance Single submitter
- CR1 p.Glu327Asp Uncertain significance Single submitter
- CR1 p.Glu713Gln Uncertain significance Single submitter
- CR1 p.Gly1577Ser Uncertain significance Single submitter
- CR1 p.Gly2072Val Uncertain significance Single submitter
- CR1 p.Gly2109Ser Uncertain significance Single submitter
- CR1 p.Gly2237Glu Uncertain significance Single submitter
- CR1 p.Gly227Ser Uncertain significance Single submitter
- CR1 p.Gly24Arg Uncertain significance Single submitter
- CR1 p.Gly363Arg Uncertain significance Single submitter
- CR1 p.His1332Tyr Uncertain significance Single submitter
- CR1 p.His1503Gln Uncertain significance Single submitter
- CR1 p.His1655Arg Uncertain significance Single submitter
- CR1 p.His1782Tyr Uncertain significance Single submitter
-
CR1 p.His2095Asn
Uncertain significance
Single submitter
polyarticular arthritis
- CR1 p.His2095Tyr Uncertain significance Single submitter
- CR1 p.His2202Arg Uncertain significance Single submitter
- CR1 p.His2202Gln Uncertain significance Single submitter
- CR1 p.Ile118Thr Uncertain significance Single submitter
- CR1 p.Ile121Val Uncertain significance Single submitter
- CR1 p.Ile1496Asn Uncertain significance Single submitter
- CR1 p.Ile1574Met Uncertain significance Single submitter
- CR1 p.Ile1861Val Uncertain significance Single submitter
- CR1 p.Ile1920Val Uncertain significance Single submitter
- CR1 p.Ile2266Thr Uncertain significance Single submitter
- CR1 p.Ile2439Thr Uncertain significance Single submitter
- CR1 p.Leu1598Ser Uncertain significance Single submitter
- CR1 p.Leu1605Phe Uncertain significance Single submitter
- CR1 p.Leu1715Phe Uncertain significance Single submitter
- CR1 p.Leu2165Val Uncertain significance Single submitter
- CR1 p.Leu2168Ile Uncertain significance Single submitter
- CR1 p.Leu2168Val Uncertain significance Single submitter
- CR1 p.Leu2318Ile Uncertain significance Single submitter
- CR1 p.Leu2332Val Uncertain significance Single submitter
- CR1 p.Lys1281Glu Uncertain significance Single submitter
-
CR1 p.Lys133Glu
Uncertain significance
Single submitter
KNOPS BLOOD GROUP SYSTEM
- CR1 p.Lys1553Asn Uncertain significance Single submitter
- CR1 p.Lys1623Arg Uncertain significance Single submitter
- CR1 p.Lys1635Glu Uncertain significance Single submitter
- CR1 p.Lys2370Arg Uncertain significance Single submitter
- CR1 p.Met1305Thr Uncertain significance Single submitter
- CR1 p.Phe1711Ile Uncertain significance Single submitter
- CR1 p.Phe2126Ile Uncertain significance Single submitter
- CR1 p.Phe2434Leu Uncertain significance Single submitter
- CR1 p.Pro11Ala Uncertain significance Single submitter
- CR1 p.Pro1324Ser Uncertain significance Single submitter
- CR1 p.Pro1354Arg Uncertain significance Single submitter
- CR1 p.Pro1618Leu Uncertain significance Single submitter
- CR1 p.Pro1786Ala Uncertain significance Single submitter
- CR1 p.Pro1853Thr Uncertain significance Single submitter
- CR1 p.Pro1878Ser Uncertain significance Single submitter
- CR1 p.Pro2002Gln Uncertain significance Single submitter
- CR1 p.Pro2031Arg Uncertain significance Single submitter
- CR1 p.Pro2104Ser Uncertain significance Single submitter
- CR1 p.Pro2411Leu Uncertain significance Single submitter
- CR1 p.Pro268Ser Uncertain significance Single submitter
- CR1 p.Pro299Ser Uncertain significance Single submitter
- CR1 p.Pro50Ser Uncertain significance Single submitter
- CR1 p.Ser1505Asn Uncertain significance Single submitter
- CR1 p.Ser1642Ile Uncertain significance Single submitter
- CR1 p.Ser1745Gly Uncertain significance Single submitter
- CR1 p.Ser1757Thr Uncertain significance Single submitter
- CR1 p.Ser1822Asn Uncertain significance Single submitter
- CR1 p.Ser1840Pro Uncertain significance Single submitter
- CR1 p.Ser189Ala Uncertain significance Single submitter
- CR1 p.Ser2037Thr Uncertain significance Single submitter
- CR1 p.Ser2057Gly Uncertain significance Single submitter
- CR1 p.Ser2128Arg Uncertain significance Single submitter
- CR1 p.Ser2215Asn Uncertain significance Single submitter
- CR1 p.Ser2269Asn Uncertain significance Single submitter
- CR1 p.Ser2400Gly Uncertain significance Single submitter
- CR1 p.Thr1209Asn Uncertain significance Single submitter
- CR1 p.Thr158Ile Uncertain significance Single submitter
- CR1 p.Thr1809Asn Uncertain significance Single submitter
- CR1 p.Thr2080Ala Uncertain significance Single submitter
- CR1 p.Thr2144Ala Uncertain significance Single submitter
- CR1 p.Thr2144Met Uncertain significance Single submitter
-
CR1 p.Thr239Met
Uncertain significance
Single submitter
KNOPS BLOOD GROUP SYSTEM
- CR1 p.Trp1309Cys Uncertain significance Single submitter
- CR1 p.Tyr214His Uncertain significance Single submitter
- CR1 p.Tyr2383His Uncertain significance Single submitter
- CR1 p.Val1270Met Uncertain significance Single submitter
- CR1 p.Val1313Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CR1 variants
Conflicting classifications of pathogenicity 5
- p.Arg308Cys Single submitter
- p.Ile1327Val Single submitter ⚠
- p.Met1884Ile Single submitter KNOPS BLOOD GROUP SYSTEM ⚠
- p.Ser1296Phe Single submitter
- p.Val2125Leu Single submitter
Benign 8
- p.Ile2065Val Multiple submitters
- p.Arg105Cys Single submitter
- p.Lys2303Arg Single submitter
- p.Val1868= Single submitter
- p.Arg2051Gly No assertion criteria CR1-related disorder
- p.His1768Tyr No assertion criteria CR1-related disorder
- p.Lys2040Glu No assertion criteria CR1-related disorder
- p.Pro2277Arg No assertion criteria CR1-related disorder
Likely benign 41
- c.5811-11C>A Multiple submitters malaria, susceptibility to
- p.Pro1218= Multiple submitters
- c.401+14T>C Single submitter
- c.487+20C>T Single submitter
- p.Arg202Lys Single submitter
- p.Arg308His Single submitter
- p.Arg789Ser Single submitter
- p.Asn1990Ser Single submitter
- p.Cys1902= Single submitter
- p.Gln572His Single submitter
- p.Glu60= Single submitter
- p.Gly1551Arg Single submitter
- p.Gly167Glu Single submitter ⚠
- p.Gly200Arg Single submitter
- p.His2420Arg Single submitter
- p.Leu2175Phe Single submitter
- p.Leu2316= Single submitter
- p.Leu2316Pro Single submitter
- p.Leu283= Single submitter
- p.Leu69= Single submitter
- p.Phe2193= Single submitter
- p.Pro197Leu Single submitter
- p.Pro2032= Single submitter
- p.Pro2239Ser Single submitter
- p.Pro268= Single submitter
- p.Thr1252Arg Single submitter
- p.Thr1358Met Single submitter
- p.Thr1589Met Single submitter
- p.Thr1858Ala Single submitter
- p.Thr1858Met Single submitter
- p.Thr2060Ser Single submitter
- p.Thr2419Ala Single submitter
- p.Thr352Arg Single submitter
- p.Thr583Pro Single submitter
- p.Tyr330= Single submitter
- p.Val115= Single submitter
- p.Val2377= Single submitter
- p.Val38= Single submitter
- p.Val38Ala Single submitter
- p.Cys326= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Gly1869Arg No assertion criteria CR1-related disorder
Uncertain significance 230
- p.Arg1208Cys Multiple submitters KNOPS BLOOD GROUP SYSTEM ⚠
- p.Arg2014Gln Multiple submitters ⚠
- p.Tyr1230Cys Multiple submitters ⚠
- c.2413+5C>T Single submitter
- p.Ala1249Val Single submitter ⚠
- p.Ala1502Thr Single submitter ⚠
- p.Ala1579Thr Single submitter ⚠
- p.Ala1685Ser Single submitter ⚠
- p.Ala1685Val Single submitter ⚠
- p.Ala1730Thr Single submitter ⚠
- p.Ala1961Pro Single submitter ⚠
- p.Ala2139Val Single submitter ⚠
- p.Ala2287Ser Single submitter
- p.Ala2297Gly Single submitter ⚠
- p.Ala2404Glu Single submitter ⚠
- p.Ala350Val Single submitter ⚠
- p.Ala623Val Single submitter ⚠
- p.Arg1239His Single submitter ⚠
- p.Arg1269Cys Single submitter ⚠
- p.Arg1369His Single submitter ⚠
- p.Arg1386His Single submitter ⚠
- p.Arg1544Ser Single submitter
- p.Arg1627Cys Single submitter ⚠
- p.Arg1627His Single submitter ⚠
- p.Arg1819Cys Single submitter ⚠
- p.Arg1836Cys Single submitter
- p.Arg1842Gly Single submitter ⚠
- p.Arg1842His Single submitter ⚠
- p.Arg1903Lys Single submitter ⚠
- p.Arg1939Leu Single submitter
- p.Arg194Cys Single submitter ⚠
- p.Arg194Ser Single submitter ⚠
- p.Arg1985Lys Single submitter ⚠
- p.Arg2014Trp Single submitter ⚠
- p.Arg2088Ser Single submitter ⚠
- p.Arg2172Cys Single submitter
- p.Arg2172His Single submitter ⚠
- p.Arg2272Cys Single submitter ⚠
- p.Arg2272His Single submitter ⚠
- p.Arg2272Ser Single submitter
- p.Arg2289Leu Single submitter ⚠
- p.Arg277Cys Single submitter
- p.Arg277His Single submitter ⚠
- p.Arg726Cys Single submitter
- p.Arg727Cys Single submitter
- p.Asn1267Ser Single submitter ⚠
- p.Asn1329Lys Single submitter
- p.Asn1811Ser Single submitter ⚠
- p.Asn2055Asp Single submitter ⚠
- p.Asn2213Ser Single submitter ⚠
- p.Asn2226Asp Single submitter ⚠
- p.Asn375Tyr Single submitter ⚠
- p.Asn89Ile Single submitter ⚠
- p.Asp1214Tyr Single submitter ⚠
- p.Asp1351Asn Single submitter ⚠
- p.Asp1361Asn Single submitter ⚠
- p.Asp1526Asn Single submitter ⚠
- p.Asp1569Gly Single submitter ⚠
- p.Asp1801Glu Single submitter
- p.Asp1801Gly Single submitter
- p.Asp2023Gly Single submitter ⚠
- p.Asp2134Tyr Single submitter ⚠
- p.Asp2162Val Single submitter ⚠
- p.Asp2190Glu Single submitter ⚠
- p.Asp2242Gly Single submitter ⚠
- p.Asp2258Asn Single submitter ⚠
- p.Asp2406Tyr Single submitter ⚠
- p.Asp2409Tyr Single submitter ⚠
- p.Asp2421His Single submitter ⚠
- p.Asp360Tyr Single submitter ⚠
- p.Asp383Asn Single submitter ⚠
- p.Cys1516Arg Single submitter ⚠
- p.Cys1750Trp Single submitter ⚠
- p.Cys2156Ser Single submitter ⚠
- p.Cys2341Ser Single submitter ⚠
- p.Cys73Phe Single submitter ⚠
- p.Gln1851Arg Single submitter ⚠
- p.Gln2167His Single submitter ⚠
- p.Gln2349Pro Single submitter ⚠
- p.Glu1306Lys Single submitter ⚠
- p.Glu2191Asp Single submitter ⚠
- p.Glu2356Asp Single submitter
- p.Glu2371Gly Single submitter ⚠
- p.Glu263Ala Single submitter ⚠
- p.Glu327Asp Single submitter ⚠
- p.Glu713Gln Single submitter ⚠
- p.Gly1219Arg Single submitter
- p.Gly1219Val Single submitter
- p.Gly1229Ser Single submitter
- p.Gly1244Glu Single submitter
- p.Gly1268Asp Single submitter
- p.Gly1294fs Single submitter KNOPS BLOOD GROUP SYSTEM
- p.Gly1577Ser Single submitter ⚠
- p.Gly1669Arg Single submitter
- p.Gly1729Glu Single submitter
- p.Gly1916Arg Single submitter
- p.Gly1991Glu Single submitter
- p.Gly2001Ala Single submitter
- p.Gly2072Arg Single submitter
- p.Gly2072Val Single submitter ⚠
- p.Gly2077Val Single submitter
- p.Gly2109Ser Single submitter ⚠
- p.Gly2147Glu Single submitter
- p.Gly2171Val Single submitter
- p.Gly2207Val Single submitter
- p.Gly2237Glu Single submitter ⚠
- p.Gly2267Ala Single submitter
- p.Gly227Ser Single submitter ⚠
- p.Gly2281Glu Single submitter
- p.Gly2311Glu Single submitter
- p.Gly2330Arg Single submitter
- p.Gly2330Ser Single submitter
- p.Gly2337Asp Single submitter
- p.Gly2367Ala Single submitter
- p.Gly24Arg Single submitter ⚠
- p.Gly363Arg Single submitter ⚠
- p.His1332Tyr Single submitter ⚠
- p.His1503Gln Single submitter ⚠
- p.His1655Arg Single submitter ⚠
- p.His1782Tyr Single submitter ⚠
- p.His2095Asn Single submitter polyarticular arthritis ⚠
- p.His2095Tyr Single submitter ⚠
- p.His2202Arg Single submitter ⚠
- p.His2202Gln Single submitter ⚠
- p.Ile118Thr Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Ile1496Asn Single submitter ⚠
- p.Ile1574Met Single submitter ⚠
- p.Ile1597Thr Single submitter
- p.Ile1861Val Single submitter ⚠
- p.Ile1887Val Single submitter
- p.Ile1920Val Single submitter ⚠
- p.Ile2266Thr Single submitter ⚠
- p.Ile2439Thr Single submitter ⚠
- p.Leu1598Ser Single submitter ⚠
- p.Leu1605Phe Single submitter ⚠
- p.Leu1682Phe Single submitter
- p.Leu1715Phe Single submitter ⚠
- p.Leu2165Val Single submitter ⚠
- p.Leu2168Ile Single submitter ⚠
- p.Leu2168Val Single submitter ⚠
- p.Leu2318Ile Single submitter ⚠
- p.Leu2332Val Single submitter ⚠
- p.Leu2437Pro Single submitter
- p.Leu69Arg Single submitter ⚠
- p.Lys1281Glu Single submitter ⚠
- p.Lys133Glu Single submitter KNOPS BLOOD GROUP SYSTEM ⚠
- p.Lys1553Asn Single submitter ⚠
- p.Lys1623Arg Single submitter ⚠
- p.Lys1635Glu Single submitter ⚠
- p.Lys2370Arg Single submitter ⚠
- p.Lys273Ile Single submitter
- p.Met1305Thr Single submitter ⚠
- p.Met272Arg Single submitter
- p.Phe1290Cys Single submitter ⚠
- p.Phe1342Ile Single submitter
- p.Phe1711Ile Single submitter ⚠
- p.Phe177Val Single submitter
- p.Phe2073Cys Single submitter
- p.Phe2126Ile Single submitter ⚠
- p.Phe2434Leu Single submitter ⚠
- p.Phe270= Single submitter
- p.Pro11Ala Single submitter ⚠
- p.Pro1314Ser Single submitter
- p.Pro1322Thr Single submitter
- p.Pro1324Ser Single submitter ⚠
- p.Pro1354Arg Single submitter ⚠
- p.Pro1591Leu Single submitter
- p.Pro1618Leu Single submitter ⚠
- p.Pro1651Ala Single submitter
- p.Pro1701Arg Single submitter
- p.Pro1701Leu Single submitter
- p.Pro1786Ala Single submitter ⚠
- p.Pro1853Thr Single submitter ⚠
- p.Pro1878Ser Single submitter ⚠
- p.Pro1910Ser Single submitter
- p.Pro1962Ala Single submitter
- p.Pro2002Gln Single submitter ⚠
- p.Pro2031Arg Single submitter ⚠
- p.Pro2094Thr Single submitter
- p.Pro2104Ser Single submitter ⚠
- p.Pro2176Arg Single submitter
- p.Pro2227Leu Single submitter
- p.Pro2411Leu Single submitter ⚠
- p.Pro268Ser Single submitter ⚠
- p.Pro299Ser Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Ser1492Pro Single submitter
- p.Ser1505Asn Single submitter ⚠
- p.Ser1642Ile Single submitter ⚠
- p.Ser1745Gly Single submitter ⚠
- p.Ser1757Thr Single submitter ⚠
- p.Ser1822Asn Single submitter ⚠
- p.Ser1840Pro Single submitter ⚠
- p.Ser189Ala Single submitter ⚠
- p.Ser2037Thr Single submitter ⚠
- p.Ser2057Gly Single submitter ⚠
- p.Ser2128Arg Single submitter ⚠
- p.Ser2215Asn Single submitter ⚠
- p.Ser2269Asn Single submitter ⚠
- p.Ser2348Arg Single submitter
- p.Ser2400Gly Single submitter ⚠
- p.Thr1209Asn Single submitter ⚠
- p.Thr158Ile Single submitter ⚠
- p.Thr1809Asn Single submitter ⚠
- p.Thr2019Pro Single submitter
- p.Thr2080Ala Single submitter ⚠
- p.Thr2144Ala Single submitter ⚠
- p.Thr2144Met Single submitter ⚠
- p.Thr239Met Single submitter KNOPS BLOOD GROUP SYSTEM ⚠
- p.Trp1309Cys Single submitter ⚠
- p.Tyr1792Ser Single submitter
- p.Tyr214His Single submitter ⚠
- p.Tyr2383His Single submitter ⚠
- p.Val1270Met Single submitter ⚠
- p.Val1313Ile Single submitter ⚠
- p.Val1611Gly Single submitter ⚠
- p.Val1753Ile Single submitter ⚠
- p.Val1829Phe Single submitter ⚠
- p.Val1918Met Single submitter ⚠
- p.Val1950Ile Single submitter ⚠
- p.Val2027Ile Single submitter ⚠
- p.Val2076Ile Single submitter ⚠
- p.Val2099Ala Single submitter ⚠
- p.Val2218Met Single submitter ⚠
- p.Val2314Ile Single submitter ⚠
- p.Val2473Ile Single submitter ⚠
- p.Val2487Asp Single submitter ⚠
- p.Val30Ala Single submitter ⚠
- p.Val374Ile Single submitter ⚠