CR1L — 110 ClinVar variants
All ClinVar germline CR1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
13 Likely benign · 97 Uncertain significance
Full CR1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CR1L p.Ala165Thr Uncertain significance Single submitter
- CR1L p.Ala22Glu Uncertain significance Single submitter
- CR1L p.Ala2Val Uncertain significance Single submitter
- CR1L p.Ala461Asp Uncertain significance Single submitter
- CR1L p.Arg15Pro Uncertain significance Single submitter
- CR1L p.Arg344Thr Uncertain significance Single submitter
- CR1L p.Arg445Gln Uncertain significance Single submitter
- CR1L p.Arg523His Uncertain significance Single submitter
- CR1L p.Arg524His Uncertain significance Single submitter
- CR1L p.Arg72Thr Uncertain significance Single submitter
- CR1L p.Asn276Ser Uncertain significance Single submitter
- CR1L p.Asn307Ser Uncertain significance Single submitter
- CR1L p.Asn459Ser Uncertain significance Single submitter
- CR1L p.Asn81Ser Uncertain significance Single submitter
- CR1L p.Asp101His Uncertain significance Single submitter
- CR1L p.Asp168Gly Uncertain significance Single submitter
- CR1L p.Asp304Glu Uncertain significance Single submitter
- CR1L p.Asp323Asn Uncertain significance Single submitter
- CR1L p.Asp352Gly Uncertain significance Single submitter
- CR1L p.Cys158Arg Uncertain significance Single submitter
- CR1L p.Cys318Arg Uncertain significance Single submitter
- CR1L p.Cys318Tyr Uncertain significance Single submitter
- CR1L p.Cys504Ser Uncertain significance Single submitter
- CR1L p.Gln259Glu Uncertain significance Single submitter
- CR1L p.Glu281Gln Uncertain significance Single submitter
- CR1L p.Glu527Lys Uncertain significance Single submitter
- CR1L p.Gly141Asp Uncertain significance Single submitter
- CR1L p.Gly546Ala Uncertain significance Single submitter
- CR1L p.Gly546Arg Uncertain significance Single submitter
- CR1L p.Gly68Arg Uncertain significance Single submitter
- CR1L p.Gly68Cys Uncertain significance Single submitter
- CR1L p.His462Asn Uncertain significance Single submitter
- CR1L p.Ile110Asn Uncertain significance Single submitter
- CR1L p.Ile130Thr Uncertain significance Single submitter
- CR1L p.Ile130Val Uncertain significance Single submitter
- CR1L p.Ile226Thr Uncertain significance Single submitter
- CR1L p.Ile430Val Uncertain significance Single submitter
- CR1L p.Ile447Phe Uncertain significance Single submitter
- CR1L p.Ile469Val Uncertain significance Single submitter
- CR1L p.Ile517Thr Uncertain significance Single submitter
- CR1L p.Ile554Thr Uncertain significance Single submitter
- CR1L p.Ile57Phe Uncertain significance Single submitter
- CR1L p.Ile57Thr Uncertain significance Single submitter
- CR1L p.Leu247Phe Uncertain significance Single submitter
- CR1L p.Leu366Val Uncertain significance Single submitter
- CR1L p.Leu482Phe Uncertain significance Single submitter
- CR1L p.Leu482Val Uncertain significance Single submitter
- CR1L p.Leu491Phe Uncertain significance Single submitter
- CR1L p.Leu553Arg Uncertain significance Single submitter
- CR1L p.Lys111Asn Uncertain significance Single submitter
- CR1L p.Lys195Asn Uncertain significance Single submitter
- CR1L p.Met106Thr Uncertain significance Single submitter
- CR1L p.Met106Val Uncertain significance Single submitter
- CR1L p.Phe11Leu Uncertain significance Single submitter
- CR1L p.Pro100Thr Uncertain significance Single submitter
- CR1L p.Pro17Ser Uncertain significance Single submitter
- CR1L p.Pro260Ser Uncertain significance Single submitter
- CR1L p.Pro267Ser Uncertain significance Single submitter
- CR1L p.Pro476Thr Uncertain significance Single submitter
- CR1L p.Pro478Leu Uncertain significance Single submitter
- CR1L p.Pro506Ala Uncertain significance Single submitter
- CR1L p.Pro506Ser Uncertain significance Single submitter
- CR1L p.Pro506Thr Uncertain significance Single submitter
- CR1L p.Pro73Arg Uncertain significance Single submitter
- CR1L p.Ser132Tyr Uncertain significance Single submitter
- CR1L p.Ser171Gly Uncertain significance Single submitter
- CR1L p.Ser349Phe Uncertain significance Single submitter
- CR1L p.Ser450Leu Uncertain significance Single submitter
- CR1L p.Thr415Ala Uncertain significance Single submitter
- CR1L p.Thr460Ala Uncertain significance Single submitter
- CR1L p.Thr503Ala Uncertain significance Single submitter
- CR1L p.Trp217Cys Uncertain significance Single submitter
- CR1L p.Trp278Gly Uncertain significance Single submitter
- CR1L p.Tyr496Cys Uncertain significance Single submitter
- CR1L p.Val25Glu Uncertain significance Single submitter
- CR1L p.Val374Met Uncertain significance Single submitter
- CR1L p.Val377Phe Uncertain significance Single submitter
- CR1L p.Val420Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CR1L p.Arg300Cys Uncertain significance Single submitter
- CR1L p.Arg66Cys Uncertain significance Single submitter
- CR1L p.Asn81Ile Uncertain significance Single submitter
- CR1L p.Asp112Gly Uncertain significance Single submitter
- CR1L p.Cys440Ser Uncertain significance Single submitter
- CR1L p.Gly321Ser Uncertain significance Single submitter
- CR1L p.Gly355Cys Uncertain significance Single submitter
- CR1L p.Gly371Glu Uncertain significance Single submitter
- CR1L p.Ile156Asn Uncertain significance Single submitter
- CR1L p.Leu79Ile Uncertain significance Single submitter
- CR1L p.Pro292Ser Uncertain significance Single submitter
- CR1L p.Pro38Leu Uncertain significance Single submitter
- CR1L p.Pro479Leu Uncertain significance Single submitter
- CR1L p.Pro73Leu Uncertain significance Single submitter
- CR1L p.Ser133Leu Uncertain significance Single submitter
- CR1L p.Ser86Gly Uncertain significance Single submitter
- CR1L p.Thr487Lys Uncertain significance Single submitter
All CR1L variants
Likely benign 13
- p.Ala107Val Single submitter
- p.Arg192Gly Single submitter
- p.Arg300His Single submitter
- p.Asp304Asn Single submitter
- p.Glu414Lys Single submitter
- p.His186Arg Single submitter
- p.Lys194Arg Single submitter
- p.Phe53Ser Single submitter
- p.Pro17= Single submitter
- p.Pro320= Single submitter
- p.Pro544Ser Single submitter
- p.Ser268= Single submitter
- p.Val418Asp Single submitter
Uncertain significance 97
- p.Ala165Thr Single submitter ⚠
- p.Ala22Glu Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala461Asp Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg344Thr Single submitter ⚠
- p.Arg445Gln Single submitter ⚠
- p.Arg523His Single submitter ⚠
- p.Arg524His Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Arg72Thr Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asn307Ser Single submitter ⚠
- p.Asn459Ser Single submitter ⚠
- p.Asn81Ile Single submitter ⚠
- p.Asn81Ser Single submitter ⚠
- p.Asp101His Single submitter ⚠
- p.Asp112Gly Single submitter ⚠
- p.Asp168Gly Single submitter ⚠
- p.Asp304Glu Single submitter ⚠
- p.Asp323Asn Single submitter ⚠
- p.Asp352Gly Single submitter ⚠
- p.Cys158Arg Single submitter ⚠
- p.Cys318Arg Single submitter ⚠
- p.Cys318Tyr Single submitter ⚠
- p.Cys440Ser Single submitter ⚠
- p.Cys504Ser Single submitter ⚠
- p.Gln259Glu Single submitter ⚠
- p.Glu281Gln Single submitter ⚠
- p.Glu527Lys Single submitter ⚠
- p.Gly141Asp Single submitter ⚠
- p.Gly321Ser Single submitter ⚠
- p.Gly355Cys Single submitter ⚠
- p.Gly371Glu Single submitter ⚠
- p.Gly518Trp Single submitter
- p.Gly546Ala Single submitter ⚠
- p.Gly546Arg Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.Gly68Cys Single submitter ⚠
- p.His462Asn Single submitter ⚠
- p.Ile110Asn Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile156Asn Single submitter ⚠
- p.Ile226Thr Single submitter ⚠
- p.Ile430Val Single submitter ⚠
- p.Ile447Phe Single submitter ⚠
- p.Ile469Val Single submitter ⚠
- p.Ile517Thr Single submitter ⚠
- p.Ile554Thr Single submitter ⚠
- p.Ile57Phe Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Leu247Phe Single submitter ⚠
- p.Leu366Val Single submitter ⚠
- p.Leu482Phe Single submitter ⚠
- p.Leu482Val Single submitter ⚠
- p.Leu491Phe Single submitter ⚠
- p.Leu553Arg Single submitter ⚠
- p.Leu79Ile Single submitter ⚠
- p.Lys111Asn Single submitter ⚠
- p.Lys195Asn Single submitter ⚠
- p.Met106Thr Single submitter ⚠
- p.Met106Val Single submitter ⚠
- p.Phe11Leu Single submitter ⚠
- p.Pro100Thr Single submitter ⚠
- p.Pro151Leu Single submitter
- p.Pro17Ser Single submitter ⚠
- p.Pro260Ser Single submitter ⚠
- p.Pro267Ser Single submitter ⚠
- p.Pro292Ser Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro476Thr Single submitter ⚠
- p.Pro478Leu Single submitter ⚠
- p.Pro479Leu Single submitter ⚠
- p.Pro506Ala Single submitter ⚠
- p.Pro506Ser Single submitter ⚠
- p.Pro506Thr Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser132Tyr Single submitter ⚠
- p.Ser133Leu Single submitter ⚠
- p.Ser171Gly Single submitter ⚠
- p.Ser349Phe Single submitter ⚠
- p.Ser450Leu Single submitter ⚠
- p.Ser86Gly Single submitter ⚠
- p.Thr415Ala Single submitter ⚠
- p.Thr460Ala Single submitter ⚠
- p.Thr487Lys Single submitter ⚠
- p.Thr503Ala Single submitter ⚠
- p.Trp217Cys Single submitter ⚠
- p.Trp278Gly Single submitter ⚠
- p.Tyr496Cys Single submitter ⚠
- p.Val25Glu Single submitter ⚠
- p.Val374Met Single submitter ⚠
- p.Val377Phe Single submitter ⚠
- p.Val420Ala Single submitter ⚠