CRABP1 — 14 ClinVar variants
All ClinVar germline CRABP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
14 Uncertain significance
Full CRABP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRABP1 p.Asp126Asn Uncertain significance Single submitter
- CRABP1 p.Cys82Phe Uncertain significance Single submitter
- CRABP1 p.His95Leu Uncertain significance Single submitter
- CRABP1 p.Leu100Ile Uncertain significance Single submitter
- CRABP1 p.Leu29Pro Uncertain significance Single submitter
- CRABP1 p.Phe4Cys Uncertain significance Single submitter
- CRABP1 p.Thr58Met Uncertain significance Single submitter
- CRABP1 p.Thr61Pro Uncertain significance Single submitter
- CRABP1 p.Thr97Arg Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CRABP1 variants
Uncertain significance 14
- p.Ala125Thr Single submitter ⚠
- p.Arg136Gln Single submitter
- p.Asp126Asn Single submitter ⚠
- p.Cys82Phe Single submitter ⚠
- p.Glu137Gln Single submitter ⚠
- p.Gly103Trp Single submitter ⚠
- p.His95Leu Single submitter ⚠
- p.Leu100Ile Single submitter ⚠
- p.Leu29Pro Single submitter ⚠
- p.Phe4Cys Single submitter ⚠
- p.Thr122Ala Single submitter ⚠
- p.Thr58Met Single submitter ⚠
- p.Thr61Pro Single submitter ⚠
- p.Thr97Arg Single submitter ⚠