CRABP2 — 23 ClinVar variants
All ClinVar germline CRABP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
2 Likely benign · 21 Uncertain significance
Full CRABP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRABP2 p.Asn26Tyr Uncertain significance Single submitter
- CRABP2 p.Glu104Asp Uncertain significance Single submitter
- CRABP2 p.Glu47Val Uncertain significance Single submitter
- CRABP2 p.Gly105Ser Uncertain significance Single submitter
- CRABP2 p.Lys107Glu Uncertain significance Single submitter
- CRABP2 p.Thr61Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CRABP2 p.Ala126Val Uncertain significance Single submitter
- CRABP2 p.Arg60Cys Uncertain significance Single submitter
- CRABP2 p.Asn26Ser Uncertain significance Single submitter
- CRABP2 p.Glu70Lys Uncertain significance Single submitter
- CRABP2 p.Gly24Glu Uncertain significance Single submitter
- CRABP2 p.Leu20Ile Uncertain significance Single submitter
- CRABP2 p.Leu85Gln Uncertain significance Single submitter
- CRABP2 p.Lys67Glu Uncertain significance Single submitter
- CRABP2 p.Ser13Leu Uncertain significance Single submitter
- CRABP2 p.Thr125Met Uncertain significance Single submitter
- CRABP2 p.Thr132Asn Uncertain significance Single submitter
- CRABP2 p.Val59Ala Uncertain significance Single submitter
- CRABP2 p.Val59Met Uncertain significance Single submitter
- CRABP2 p.Val68Ala Uncertain significance Single submitter
All CRABP2 variants
Likely benign 2
- p.Leu122= Single submitter
- p.Val129Ile Single submitter
Uncertain significance 21
- p.Ala126Val Single submitter ⚠
- p.Arg137Gln Single submitter
- p.Arg60Cys Single submitter ⚠
- p.Asn26Ser Single submitter ⚠
- p.Asn26Tyr Single submitter ⚠
- p.Glu104Asp Single submitter ⚠
- p.Glu47Val Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly105Ser Single submitter ⚠
- p.Gly24Glu Single submitter ⚠
- p.Leu20Ile Single submitter ⚠
- p.Leu85Gln Single submitter ⚠
- p.Lys107Glu Single submitter ⚠
- p.Lys67Glu Single submitter ⚠
- p.Ser13Leu Single submitter ⚠
- p.Thr125Met Single submitter ⚠
- p.Thr132Asn Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Val59Ala Single submitter ⚠
- p.Val59Met Single submitter ⚠
- p.Val68Ala Single submitter ⚠