CRACD — 232 ClinVar variants

All ClinVar germline CRACD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 218 flagged for review →

7 Likely benign · 225 Uncertain significance

Full CRACD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 218

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 186

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 186

Predictors split 32

The independent predictors disagree with each other — read with care.

All CRACD variants

Likely benign 7

p.Arg1013Pro Single submitter
p.Arg52Pro Single submitter
p.Arg927His Single submitter
p.Gly368Arg Single submitter
p.Gly417Val Single submitter
p.Ser754Gly Single submitter
p.Val88Ile Single submitter

Uncertain significance 225

p.Ala1035Gly Single submitter ⚠
p.Ala1105Val Single submitter ⚠
p.Ala1116Asp Single submitter ⚠
p.Ala1149Pro Single submitter ⚠
p.Ala1149Val Single submitter ⚠
p.Ala1190Val Single submitter ⚠
p.Ala283Val Single submitter ⚠
p.Ala303Thr Single submitter ⚠
p.Ala325Val Single submitter ⚠
p.Ala327Ser Single submitter ⚠
p.Ala329Val Single submitter ⚠
p.Ala355Ser Single submitter ⚠
p.Ala355Val Single submitter ⚠
p.Ala377Val Single submitter ⚠
p.Ala385Ser Single submitter ⚠
p.Ala385Val Single submitter ⚠
p.Ala396Thr Single submitter ⚠
p.Ala511Thr Single submitter ⚠
p.Ala561Thr Single submitter ⚠
p.Ala601Gly Single submitter ⚠
p.Ala62Thr Single submitter ⚠
p.Ala664Ser Single submitter ⚠
p.Ala664Thr Single submitter ⚠
p.Ala758Val Single submitter ⚠
p.Ala783Ser Single submitter ⚠
p.Ala881Val Single submitter ⚠
p.Ala951Val Single submitter ⚠
p.Ala964Thr Single submitter ⚠
p.Ala964Val Single submitter ⚠
p.Arg1014Trp Single submitter ⚠
p.Arg1038Gly Single submitter ⚠
p.Arg126Trp Single submitter ⚠
p.Arg151Cys Single submitter ⚠
p.Arg151His Single submitter ⚠
p.Arg176His Single submitter ⚠
p.Arg223Cys Single submitter ⚠
p.Arg237Pro Single submitter ⚠
p.Arg246Thr Single submitter ⚠
p.Arg265Lys Single submitter ⚠
p.Arg288Pro Single submitter ⚠
p.Arg293Trp Single submitter ⚠
p.Arg305Pro Single submitter ⚠
p.Arg340Ser Single submitter ⚠
p.Arg393Gln Single submitter ⚠
p.Arg435Cys Single submitter ⚠
p.Arg435Pro Single submitter ⚠
p.Arg4Gln Single submitter ⚠
p.Arg4Gly Single submitter ⚠
p.Arg4Trp Single submitter ⚠
p.Arg523Trp Single submitter ⚠
p.Arg52Gln Single submitter ⚠
p.Arg52Trp Single submitter ⚠
p.Arg684Cys Single submitter ⚠
p.Arg688Ser Single submitter ⚠
p.Arg700Thr Single submitter ⚠
p.Arg702Gln Single submitter ⚠
p.Arg710Gln Single submitter ⚠
p.Arg890Gly Single submitter ⚠
p.Arg890Ser Single submitter ⚠
p.Arg917Gly Single submitter ⚠
p.Arg917Pro Single submitter ⚠
p.Arg927Leu Single submitter ⚠
p.Asn609Thr Single submitter ⚠
p.Asn853Ser Single submitter ⚠
p.Asn94Asp Single submitter ⚠
p.Asp1185Asn Single submitter
p.Asp195Glu Single submitter ⚠
p.Asp338Asn Single submitter ⚠
p.Asp563Gly Single submitter ⚠
p.Asp730His Single submitter ⚠
p.Asp821His Single submitter ⚠
p.Cys354Ser Single submitter ⚠
p.Cys618Ser Single submitter ⚠
p.Gln1118Glu Single submitter ⚠
p.Gln1118Lys Single submitter ⚠
p.Gln185Glu Single submitter ⚠
p.Gln324Arg Single submitter ⚠
p.Gln361Arg Single submitter ⚠
p.Gln441Arg Single submitter ⚠
p.Gln531His Single submitter ⚠
p.Gln547His Single submitter ⚠
p.Gln571Arg Single submitter ⚠
p.Gln602Pro Single submitter ⚠
p.Gln656Lys Single submitter ⚠
p.Glu1034Lys Single submitter ⚠
p.Glu1157Lys Single submitter
p.Glu1195Asp Single submitter ⚠
p.Glu1195Val Single submitter
p.Glu202Lys Single submitter ⚠
p.Glu210Asp Single submitter ⚠
p.Glu220Lys Single submitter ⚠
p.Glu225Asp Single submitter ⚠
p.Glu225Gln Single submitter ⚠
p.Glu241Lys Single submitter ⚠
p.Glu244Lys Single submitter ⚠
p.Glu271Gln Single submitter ⚠
p.Glu309Lys Single submitter ⚠
p.Glu310Ala Single submitter ⚠
p.Glu336Ala Single submitter ⚠
p.Glu342Gly Single submitter ⚠
p.Glu348Gln Single submitter ⚠
p.Glu371Gly Single submitter ⚠
p.Glu376Lys Single submitter ⚠
p.Glu384Gln Single submitter ⚠
p.Glu388Gly Single submitter ⚠
p.Glu397Lys Single submitter ⚠
p.Glu413Gln Single submitter ⚠
p.Glu446Gln Single submitter ⚠
p.Glu447Lys Single submitter ⚠
p.Glu509Lys Single submitter ⚠
p.Glu526Val Single submitter ⚠
p.Glu680Lys Single submitter ⚠
p.Glu687Val Single submitter ⚠
p.Glu696Gly Single submitter ⚠
p.Glu815Asp Single submitter ⚠
p.Glu894Gln Single submitter ⚠
p.Glu894Lys Single submitter ⚠
p.Glu999Asp Single submitter ⚠
p.Gly110Glu Single submitter ⚠
p.Gly198Arg Single submitter ⚠
p.Gly368Glu Single submitter ⚠
p.Gly408Asp Single submitter ⚠
p.Gly650Arg Single submitter ⚠
p.Gly694Asp Single submitter ⚠
p.Gly701Ser Single submitter ⚠
p.Gly701Val Single submitter ⚠
p.Gly731Asp Single submitter ⚠
p.Gly765Ser Single submitter ⚠
p.Gly876Arg Single submitter ⚠
p.Gly876Glu Single submitter ⚠
p.Gly887Arg Single submitter ⚠
p.Gly897Arg Single submitter ⚠
p.Gly903Asp Single submitter ⚠
p.Gly935Glu Single submitter ⚠
p.His1145Asp Single submitter
p.His1145Leu Single submitter ⚠
p.His583Gln Single submitter ⚠
p.Ile1090Val Single submitter ⚠
p.Ile548Val Single submitter ⚠
p.Ile671Val Single submitter ⚠
p.Ile81Thr Single submitter ⚠
p.Ile87Val Single submitter ⚠
p.Leu1067Phe Single submitter ⚠
p.Leu248Ile Single submitter ⚠
p.Leu256Met Single submitter ⚠
p.Leu269Arg Single submitter ⚠
p.Leu372Val Single submitter ⚠
p.Leu386Ser Single submitter ⚠
p.Leu401Pro Single submitter ⚠
p.Leu603Phe Single submitter ⚠
p.Leu624Ser Single submitter ⚠
p.Leu803Phe Single submitter ⚠
p.Leu957Gln Single submitter ⚠
p.Lys172Glu Single submitter ⚠
p.Lys234Glu Single submitter ⚠
p.Lys37Arg Single submitter ⚠
p.Lys552Asn Single submitter ⚠
p.Lys628Gln Single submitter ⚠
p.Lys727Ile Single submitter ⚠
p.Lys95Met Single submitter ⚠
p.Met722Thr Single submitter ⚠
p.Met750Ile Single submitter ⚠
p.Met79Lys Single submitter ⚠
p.Met895Val Single submitter ⚠
p.Phe49Leu Single submitter ⚠
p.Phe798Cys Single submitter ⚠
p.Pro1000Leu Single submitter ⚠
p.Pro1003Ser Single submitter ⚠
p.Pro1065Leu Single submitter ⚠
p.Pro279Ser Single submitter ⚠
p.Pro287Arg Single submitter ⚠
p.Pro438Ser Single submitter ⚠
p.Pro606Ala Single submitter ⚠
p.Pro638Ala Single submitter ⚠
p.Pro654Arg Single submitter ⚠
p.Pro654His Single submitter ⚠
p.Pro753Ser Single submitter ⚠
p.Pro773Leu Single submitter ⚠
p.Pro804Ser Single submitter ⚠
p.Pro883Gln Single submitter ⚠
p.Pro883Leu Single submitter ⚠
p.Pro944Leu Single submitter ⚠
p.Pro946Leu Single submitter ⚠
p.Pro983Thr Single submitter
p.Pro996Gln Single submitter ⚠
p.Ser1069Gly Single submitter ⚠
p.Ser1135Arg Single submitter
p.Ser1136Gly Single submitter ⚠
p.Ser1161Tyr Single submitter ⚠
p.Ser132Phe Single submitter ⚠
p.Ser20Gly Single submitter ⚠
p.Ser543Pro Single submitter ⚠
p.Ser579Asn Single submitter ⚠
p.Ser587Leu Single submitter ⚠
p.Ser658Tyr Single submitter ⚠
p.Ser686Arg Single submitter ⚠
p.Ser705Tyr Single submitter ⚠
p.Ser720Phe Single submitter ⚠
p.Ser802Asn Single submitter ⚠
p.Ser843Pro Single submitter ⚠
p.Ser888Ile Single submitter ⚠
p.Ser925Arg Single submitter ⚠
p.Ser975Pro Single submitter ⚠
p.Thr1091Met Single submitter ⚠
p.Thr1106Met Single submitter ⚠
p.Thr1148Ser Single submitter ⚠
p.Thr1177Met Single submitter ⚠
p.Thr1210Ala Single submitter ⚠
p.Thr23Ile Single submitter ⚠
p.Thr3Ala Single submitter ⚠
p.Thr488Met Single submitter ⚠
p.Thr538Met Single submitter
p.Thr564Met Single submitter ⚠
p.Thr594Ser Single submitter ⚠
p.Thr712Ile Single submitter ⚠
p.Thr875Ala Single submitter ⚠
p.Thr99Met Single submitter ⚠
p.Trp415Cys Single submitter ⚠
p.Val1131Met Single submitter ⚠
p.Val1179Met Single submitter ⚠
p.Val1208Met Single submitter ⚠
p.Val505Ala Single submitter ⚠
p.Val505Leu Single submitter ⚠
p.Val541Gly Single submitter ⚠
p.Val591Phe Single submitter ⚠