CRACDL — 181 ClinVar variants

All ClinVar germline CRACDL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 169 flagged for review →

2 Benign · 9 Likely benign · 170 Uncertain significance

Full CRACDL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 169

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 146

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All CRACDL variants

Benign 2

p.Arg893Gln Multiple submitters
p.Pro864= Multiple submitters

Likely benign 9

p.Ala305Val Single submitter
p.Ala823Val Single submitter
p.Ala890Thr Single submitter
p.Arg544Gln Single submitter
p.Arg802His Single submitter
p.Glu463Gly Single submitter
p.Gly326Ser Single submitter
p.Gly628Asp Single submitter
p.Phe901Leu Single submitter

Uncertain significance 170

p.Ala307Thr Single submitter ⚠
p.Ala347Val Single submitter ⚠
p.Ala375Glu Single submitter ⚠
p.Ala378Gly Single submitter ⚠
p.Ala394Val Single submitter ⚠
p.Ala399Thr Single submitter ⚠
p.Ala464Gly Single submitter ⚠
p.Ala486Gly Single submitter ⚠
p.Ala486Val Single submitter ⚠
p.Ala488Asp Single submitter ⚠
p.Ala535Thr Single submitter ⚠
p.Ala535Val Single submitter ⚠
p.Ala571Glu Single submitter ⚠
p.Ala660Thr Single submitter ⚠
p.Ala669Val Single submitter ⚠
p.Ala674Thr Single submitter ⚠
p.Ala805Pro Single submitter ⚠
p.Ala813Val Single submitter ⚠
p.Ala890Pro Single submitter ⚠
p.Ala890Ser Single submitter ⚠
p.Ala936Val Single submitter ⚠
p.Arg107Gln Single submitter ⚠
p.Arg12Trp Single submitter ⚠
p.Arg147Gln Single submitter ⚠
p.Arg147Trp Single submitter ⚠
p.Arg197Gln Single submitter ⚠
p.Arg197Trp Single submitter ⚠
p.Arg233Cys Single submitter ⚠
p.Arg277Cys Single submitter ⚠
p.Arg277His Single submitter ⚠
p.Arg306Cys Single submitter ⚠
p.Arg306Leu Single submitter ⚠
p.Arg433Cys Single submitter ⚠
p.Arg478Ser Single submitter ⚠
p.Arg544Leu Single submitter ⚠
p.Arg559Gln Single submitter ⚠
p.Arg580Gly Single submitter ⚠
p.Arg584Leu Single submitter ⚠
p.Arg651Leu Single submitter ⚠
p.Arg664Ser Single submitter ⚠
p.Arg679Gly Single submitter ⚠
p.Arg687Gln Single submitter ⚠
p.Arg696Lys Single submitter ⚠
p.Arg717Ser Single submitter ⚠
p.Arg751Gln Single submitter ⚠
p.Arg751Pro Single submitter ⚠
p.Arg751Trp Single submitter ⚠
p.Arg802Leu Single submitter ⚠
p.Arg831Leu Single submitter ⚠
p.Arg831Trp Single submitter ⚠
p.Arg835Gly Single submitter ⚠
p.Arg851Trp Single submitter ⚠
p.Arg893Trp Single submitter ⚠
p.Asn131Lys Single submitter ⚠
p.Asn234Lys Single submitter ⚠
p.Asn900Thr Single submitter ⚠
p.Asp191Asn Single submitter ⚠
p.Asp448Gly Single submitter ⚠
p.Asp614Glu Single submitter ⚠
p.Asp642Asn Single submitter ⚠
p.Asp678Asn Single submitter ⚠
p.Asp94Asn Single submitter ⚠
p.Cys218Phe Single submitter ⚠
p.Gln235Glu Single submitter ⚠
p.Gln655His Single submitter ⚠
p.Gln860Leu Single submitter ⚠
p.Glu261Lys Single submitter ⚠
p.Glu263Lys Single submitter ⚠
p.Glu266Lys Single submitter ⚠
p.Glu324Lys Single submitter ⚠
p.Glu345Lys Single submitter ⚠
p.Glu374Asp Single submitter ⚠
p.Glu423Lys Single submitter ⚠
p.Glu461Lys Single submitter ⚠
p.Glu465Gly Single submitter ⚠
p.Glu469Lys Single submitter ⚠
p.Glu475Asp Single submitter ⚠
p.Glu475Gln Single submitter ⚠
p.Glu538Lys Single submitter ⚠
p.Glu543Lys Single submitter ⚠
p.Glu558Val Single submitter ⚠
p.Glu67Lys Single submitter ⚠
p.Glu76Lys Single submitter ⚠
p.Glu792Lys Single submitter ⚠
p.Glu869Asp Single submitter ⚠
p.Gly102Arg Single submitter ⚠
p.Gly159Arg Single submitter ⚠
p.Gly19Glu Single submitter ⚠
p.Gly409Arg Single submitter ⚠
p.Gly471Glu Single submitter ⚠
p.Gly528Ser Single submitter ⚠
p.Gly570Val Single submitter ⚠
p.Gly636Arg Single submitter ⚠
p.Gly748Trp Single submitter ⚠
p.His624Gln Single submitter ⚠
p.Leu243Pro Single submitter ⚠
p.Leu350Val Single submitter ⚠
p.Leu498Pro Single submitter ⚠
p.Leu809Val Single submitter ⚠
p.Leu911Ser Single submitter ⚠
p.Lys133Gln Single submitter ⚠
p.Lys495Arg Single submitter ⚠
p.Lys704Asn Single submitter ⚠
p.Lys765Asn Single submitter ⚠
p.Lys807Asn Single submitter ⚠
p.Lys859Asn Single submitter ⚠
p.Lys872Arg Single submitter ⚠
p.Met134Val Single submitter ⚠
p.Phe574Tyr Single submitter ⚠
p.Phe771Ser Single submitter ⚠
p.Phe901Ser Single submitter ⚠
p.Pro138Ala Single submitter ⚠
p.Pro332Ser Single submitter ⚠
p.Pro339Leu Single submitter ⚠
p.Pro357Ser Single submitter ⚠
p.Pro361His Single submitter ⚠
p.Pro383Ser Single submitter ⚠
p.Pro413Thr Single submitter ⚠
p.Pro447Ser Single submitter ⚠
p.Pro453Leu Single submitter ⚠
p.Pro453Ser Single submitter ⚠
p.Pro454Arg Single submitter ⚠
p.Pro468Leu Single submitter ⚠
p.Pro46Leu Single submitter ⚠
p.Pro548Ser Single submitter ⚠
p.Pro549Ser Single submitter ⚠
p.Pro557Thr Single submitter ⚠
p.Pro583Ser Single submitter ⚠
p.Pro622His Single submitter ⚠
p.Pro647Arg Single submitter ⚠
p.Pro661Ser Single submitter ⚠
p.Pro666Ala Single submitter ⚠
p.Pro668Gln Single submitter ⚠
p.Pro675Leu Single submitter ⚠
p.Pro681Ser Single submitter ⚠
p.Pro734Ala Single submitter ⚠
p.Pro766Thr Single submitter ⚠
p.Pro780Arg Single submitter ⚠
p.Pro800Leu Single submitter ⚠
p.Pro825Leu Single submitter ⚠
p.Ser154Asn Single submitter ⚠
p.Ser245Leu Single submitter ⚠
p.Ser280Tyr Single submitter ⚠
p.Ser334Arg Single submitter ⚠
p.Ser356Tyr Single submitter ⚠
p.Ser400Ile Single submitter ⚠
p.Ser434Arg Single submitter ⚠
p.Ser575Leu Single submitter ⚠
p.Ser575Trp Single submitter
p.Ser646Arg Single submitter ⚠
p.Ser653Asn Single submitter ⚠
p.Ser676Asn Single submitter ⚠
p.Ser879Arg Single submitter ⚠
p.Ser951Ala Single submitter ⚠
p.Thr481Pro Single submitter ⚠
p.Thr485Lys Single submitter ⚠
p.Thr485Met Single submitter ⚠
p.Thr53Pro Single submitter ⚠
p.Thr59Met Single submitter ⚠
p.Thr689Ser Single submitter ⚠
p.Thr732Met Single submitter ⚠
p.Thr772Met Single submitter ⚠
p.Thr830Ile Single submitter ⚠
p.Tyr709His Single submitter ⚠
p.Val194Ile Single submitter ⚠
p.Val285Met Single submitter ⚠
p.Val398Ile Single submitter ⚠
p.Val445Met Single submitter ⚠
p.Val523Met Single submitter ⚠
p.Val877Ile Single submitter ⚠