CRADD — 84 ClinVar variants
All ClinVar germline CRADD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
4 Pathogenic · 1 Pathogenic/Likely pathogenic · 3 Likely pathogenic · 2 Conflicting · 9 Benign · 1 Benign/Likely benign · 30 Likely benign · 34 Uncertain significance
Full CRADD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 2
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
CRADD p.Arg170His
Pathogenic
Multiple submitters
intellectual disability
-
CRADD p.Arg170Cys
Likely pathogenic
Single submitter
intellectual disability, autosomal recessive 34
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
CRADD p.Gly128Arg
Conflicting
Single submitter
intellectual disability, autosomal recessive 34
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CRADD p.Arg166His
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
CRADD p.Arg168Gln
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
CRADD p.Asn45Ser
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
CRADD p.Glu15Lys
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
CRADD p.Ile106Phe
Uncertain significance
Multiple submitters
intellectual disability, autosomal recessive 34
- CRADD p.Ala99Val Uncertain significance Single submitter
- CRADD p.Arg168Trp Uncertain significance Single submitter
-
CRADD p.Asn112Ser
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Asp70Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Glu84Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Glu91Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Gly105Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Gly50Ser
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Gly65Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.His154Tyr
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.His40Asp
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Ile106Val
Uncertain significance
Single submitter
Inborn genetic diseases
- CRADD p.Leu97Val Uncertain significance Single submitter
-
CRADD p.Met197Val
Uncertain significance
Single submitter
Inborn genetic diseases
- CRADD p.Thr71Ala Uncertain significance Single submitter
- CRADD p.Val135Leu Uncertain significance Single submitter
-
CRADD p.Val156Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
CRADD p.Val22Ala
Uncertain significance
Single submitter
Inborn genetic diseases
Predictors split 7
The independent predictors disagree with each other — read with care.
-
CRADD p.Ile44Leu
Likely benign
Multiple submitters
Inborn genetic diseases
- CRADD p.Glu38Lys Uncertain significance Single submitter
-
CRADD p.Gly172Arg
Uncertain significance
Single submitter
Inborn genetic diseases
- CRADD p.Leu56Pro Uncertain significance Single submitter
-
CRADD p.Phe164Cys
Uncertain significance
Single submitter
intellectual disability, autosomal recessive 34
- CRADD p.Thr37Met Uncertain significance Single submitter
-
CRADD p.Thr54Ile
Uncertain significance
Single submitter
Inborn genetic diseases
All CRADD variants
Pathogenic 4
- p.Ala18fs Multiple submitters
- p.Arg170His Multiple submitters intellectual disability ⚠
- p.Met1Thr Single submitter intellectual disability
- p.Met1Arg No assertion criteria Moderate intellectual disability
Pathogenic/Likely pathogenic 1
- p.Trp131Ter Multiple submitters intellectual disability, autosomal recessive 34
Likely pathogenic 3
- p.Gly17fs Multiple submitters intellectual disability, autosomal recessive 34
- c.298+59160del Single submitter
- p.Arg170Cys Single submitter intellectual disability, autosomal recessive 34 ⚠
Conflicting classifications of pathogenicity 2
- p.Asp96fs Single submitter intellectual disability, autosomal recessive 34
- p.Gly128Arg Single submitter intellectual disability, autosomal recessive 34 ⚠
Benign 9
- c.298+59209G>T Multiple submitters
- c.298+59212T>C Multiple submitters
- c.298+59338T>A Multiple submitters
- c.299-75C>T Multiple submitters
- p.Arg185Gln Multiple submitters
- p.Ile35Val Multiple submitters
- p.Leu136= Multiple submitters
- c.298+58965G>A Single submitter
- p.Ser114= Single submitter
Benign/Likely benign 1
- p.Glu199= Multiple submitters
Likely benign 30
- c.298+59159A>G Multiple submitters
- p.Asn182= Multiple submitters
- p.Ile44Leu Multiple submitters Inborn genetic diseases ⚠
- p.Leu51Ile Multiple submitters
- p.Leu9= Multiple submitters
- p.Thr143= Multiple submitters
- c.298+59109C>T Single submitter
- c.298+59132A>G Single submitter
- c.299-14T>C Single submitter
- c.299-18T>G Single submitter
- p.Ala68= Single submitter
- p.Arg118Gln Single submitter Inborn genetic diseases
- p.Arg13= Single submitter
- p.Arg166= Single submitter
- p.Asn155= Single submitter
- p.Glu92= Single submitter
- p.Ile110= Single submitter
- p.Leu117= Single submitter
- p.Leu195= Single submitter
- p.Leu56= Single submitter
- p.Lys67= Single submitter
- p.Lys87= Single submitter
- p.Lys88= Single submitter
- p.Phe177= Single submitter
- p.Ser108= Single submitter
- p.Ser158= Single submitter
- p.Ser192Leu Single submitter Inborn genetic diseases
- p.Thr143Met Single submitter
- p.Val20= Single submitter
- p.Ile106= No assertion criteria CRADD-related disorder
Uncertain significance 34
- c.-6-7T>C Multiple submitters intellectual disability, autosomal recessive 34
- p.Arg10Cys Multiple submitters Inborn genetic diseases
- p.Arg166His Multiple submitters Inborn genetic diseases ⚠
- p.Arg168Gln Multiple submitters Inborn genetic diseases ⚠
- p.Asn45Ser Multiple submitters Inborn genetic diseases ⚠
- p.Glu15Lys Multiple submitters Inborn genetic diseases ⚠
- p.Ile106Phe Multiple submitters intellectual disability, autosomal recessive 34 ⚠
- c.-2A>G Single submitter intellectual disability, autosomal recessive 34
- p.Ala163Val Single submitter
- p.Ala99Val Single submitter ⚠
- p.Arg168Trp Single submitter ⚠
- p.Asn112Ser Single submitter Inborn genetic diseases ⚠
- p.Asp70Val Single submitter Inborn genetic diseases ⚠
- p.Gln7= Single submitter intellectual disability, autosomal recessive 34
- p.Glu38Lys Single submitter ⚠
- p.Glu84Gly Single submitter Inborn genetic diseases ⚠
- p.Glu91Gly Single submitter Inborn genetic diseases ⚠
- p.Gly105Val Single submitter Inborn genetic diseases ⚠
- p.Gly172Arg Single submitter Inborn genetic diseases ⚠
- p.Gly50Ser Single submitter Inborn genetic diseases ⚠
- p.Gly65Val Single submitter Inborn genetic diseases ⚠
- p.His154Tyr Single submitter Inborn genetic diseases ⚠
- p.His40Asp Single submitter Inborn genetic diseases ⚠
- p.Ile106Val Single submitter Inborn genetic diseases ⚠
- p.Leu56Pro Single submitter ⚠
- p.Leu97Val Single submitter ⚠
- p.Met197Val Single submitter Inborn genetic diseases ⚠
- p.Phe164Cys Single submitter intellectual disability, autosomal recessive 34 ⚠
- p.Thr37Met Single submitter ⚠
- p.Thr54Ile Single submitter Inborn genetic diseases ⚠
- p.Thr71Ala Single submitter ⚠
- p.Val135Leu Single submitter ⚠
- p.Val156Met Single submitter Inborn genetic diseases ⚠
- p.Val22Ala Single submitter Inborn genetic diseases ⚠