CRCP — 23 ClinVar variants
All ClinVar germline CRCP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
23 Uncertain significance
Full CRCP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRCP p.Arg90Trp Uncertain significance Single submitter
- CRCP p.Asn41Lys Uncertain significance Single submitter
- CRCP p.Gln132Pro Uncertain significance Single submitter
- CRCP p.Thr44Ile Uncertain significance Single submitter
- CRCP p.Thr79Ile Uncertain significance Single submitter
- CRCP p.Val120Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CRCP p.Glu144Lys Uncertain significance Multiple submitters
- CRCP p.Ala72Thr Uncertain significance Single submitter
- CRCP p.Ala9Val Uncertain significance Single submitter
- CRCP p.Arg27Cys Uncertain significance Single submitter
- CRCP p.Arg59Gly Uncertain significance Single submitter
- CRCP p.Arg90Gln Uncertain significance Single submitter
- CRCP p.Asn135His Uncertain significance Single submitter
- CRCP p.Asn135Ile Uncertain significance Single submitter
- CRCP p.Glu131Ala Uncertain significance Single submitter
- CRCP p.Glu131Lys Uncertain significance Single submitter
- CRCP p.Glu25Gly Uncertain significance Single submitter
- CRCP p.Glu25Lys Uncertain significance Single submitter
- CRCP p.Glu64Ala Uncertain significance Single submitter
- CRCP p.Ile113Thr Uncertain significance Single submitter
- CRCP p.Met142Val Uncertain significance Single submitter
- CRCP p.Pro57Ser Uncertain significance Single submitter
- CRCP p.Ser36Gly Uncertain significance Single submitter
All CRCP variants
Uncertain significance 23
- p.Glu144Lys Multiple submitters ⚠
- p.Ala72Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg27Cys Single submitter ⚠
- p.Arg59Gly Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asn135His Single submitter ⚠
- p.Asn135Ile Single submitter ⚠
- p.Asn41Lys Single submitter ⚠
- p.Gln132Pro Single submitter ⚠
- p.Glu131Ala Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu64Ala Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Met142Val Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Ser36Gly Single submitter ⚠
- p.Thr44Ile Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Val120Ile Single submitter ⚠