CRCT1 — 21 ClinVar variants
All ClinVar germline CRCT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Likely benign · 20 Uncertain significance
Full CRCT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 17
The independent predictors disagree with each other — read with care.
- CRCT1 p.Ala22Pro Uncertain significance Single submitter
- CRCT1 p.Arg67Ser Uncertain significance Single submitter
- CRCT1 p.Arg68His Uncertain significance Single submitter
- CRCT1 p.Asn89His Uncertain significance Single submitter
- CRCT1 p.Asn89Lys Uncertain significance Single submitter
- CRCT1 p.Cys39Tyr Uncertain significance Single submitter
- CRCT1 p.Gly41Arg Uncertain significance Single submitter
- CRCT1 p.Gly43Arg Uncertain significance Single submitter
- CRCT1 p.Gly98Asp Uncertain significance Single submitter
- CRCT1 p.Pro23Leu Uncertain significance Single submitter
- CRCT1 p.Pro27Arg Uncertain significance Single submitter
- CRCT1 p.Pro27Leu Uncertain significance Single submitter
- CRCT1 p.Pro31Arg Uncertain significance Single submitter
- CRCT1 p.Ser42Phe Uncertain significance Single submitter
- CRCT1 p.Ser55Phe Uncertain significance Single submitter
- CRCT1 p.Ser72Asn Uncertain significance Single submitter
- CRCT1 p.Ser9Cys Uncertain significance Single submitter
All CRCT1 variants
Likely benign 1
- p.Val8Ala Single submitter
Uncertain significance 20
- p.Ala22Pro Single submitter ⚠
- p.Ala28Glu Single submitter ⚠
- p.Arg67Ser Single submitter ⚠
- p.Arg68His Single submitter ⚠
- p.Asn89His Single submitter ⚠
- p.Asn89Lys Single submitter ⚠
- p.Asn89Ser Single submitter ⚠
- p.Cys39Tyr Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly98Asp Single submitter ⚠
- p.Gly98Ser Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro27Arg Single submitter ⚠
- p.Pro27Leu Single submitter ⚠
- p.Pro31Arg Single submitter ⚠
- p.Ser42Phe Single submitter ⚠
- p.Ser55Phe Single submitter ⚠
- p.Ser72Asn Single submitter ⚠
- p.Ser9Cys Single submitter ⚠