CREB3 — 51 ClinVar variants
All ClinVar germline CREB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Benign · 3 Likely benign · 46 Uncertain significance
Full CREB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CREB3 p.Ala113Val Uncertain significance Single submitter
- CREB3 p.Arg155Pro Uncertain significance Single submitter
- CREB3 p.Arg168Cys Uncertain significance Single submitter
- CREB3 p.Arg85Trp Uncertain significance Single submitter
- CREB3 p.Asp6Gly Uncertain significance Single submitter
- CREB3 p.Asp91Asn Uncertain significance Single submitter
- CREB3 p.Gln103Glu Uncertain significance Single submitter
- CREB3 p.Gln115Glu Uncertain significance Single submitter
- CREB3 p.Glu110Gln Uncertain significance Single submitter
- CREB3 p.Gly177Ser Uncertain significance Single submitter
- CREB3 p.Gly24Glu Uncertain significance Single submitter
- CREB3 p.Ile150Thr Uncertain significance Single submitter
- CREB3 p.Leu130Trp Uncertain significance Single submitter
- CREB3 p.Leu337Val Uncertain significance Single submitter
- CREB3 p.Lys132Glu Uncertain significance Single submitter
- CREB3 p.Lys171Gln Uncertain significance Single submitter
- CREB3 p.Lys184Thr Uncertain significance Single submitter
- CREB3 p.Met315Thr Uncertain significance Single submitter
- CREB3 p.Met90Val Uncertain significance Single submitter
- CREB3 p.Pro274Leu Uncertain significance Single submitter
- CREB3 p.Pro287Leu Uncertain significance Single submitter
- CREB3 p.Pro287Ser Uncertain significance Single submitter
- CREB3 p.Pro323Leu Uncertain significance Single submitter
- CREB3 p.Pro324Arg Uncertain significance Single submitter
- CREB3 p.Pro344Leu Uncertain significance Single submitter
- CREB3 p.Pro60Thr Uncertain significance Single submitter
- CREB3 p.Ser128Gly Uncertain significance Single submitter
- CREB3 p.Ser227Thr Uncertain significance Single submitter
- CREB3 p.Thr291Ile Uncertain significance Single submitter
- CREB3 p.Val363Gly Uncertain significance Single submitter
- CREB3 p.Val88Leu Uncertain significance Single submitter
-
CREB3 p.Tyr275Asp
Uncertain significance
No assertion criteria
breast ductal adenocarcinoma
Predictors split 14
The independent predictors disagree with each other — read with care.
- CREB3 p.Arg153Cys Uncertain significance Single submitter
- CREB3 p.Arg155Trp Uncertain significance Single submitter
- CREB3 p.Arg264Cys Uncertain significance Single submitter
- CREB3 p.Gln202His Uncertain significance Single submitter
- CREB3 p.Gln202Lys Uncertain significance Single submitter
- CREB3 p.Glu148Lys Uncertain significance Single submitter
- CREB3 p.Glu166Ala Uncertain significance Single submitter
- CREB3 p.Glu49Lys Uncertain significance Single submitter
- CREB3 p.Leu235Val Uncertain significance Single submitter
- CREB3 p.Lys212Glu Uncertain significance Single submitter
- CREB3 p.Pro40Leu Uncertain significance Single submitter
- CREB3 p.Thr140Ile Uncertain significance Single submitter
- CREB3 p.Thr224Ile Uncertain significance Single submitter
- CREB3 p.Tyr185His Uncertain significance Single submitter
All CREB3 variants
Benign 2
- c.697-5T>C Multiple submitters
- p.Asn222= Multiple submitters
Likely benign 3
- p.Leu53Phe Single submitter
- p.Tyr275His Single submitter
- p.Val175= Single submitter
Uncertain significance 46
- p.Ala113Val Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg155Pro Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Asp6Gly Single submitter ⚠
- p.Asp91Asn Single submitter ⚠
- p.Gln103Glu Single submitter ⚠
- p.Gln115Glu Single submitter ⚠
- p.Gln202His Single submitter ⚠
- p.Gln202Lys Single submitter ⚠
- p.Glu110Gln Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu166Ala Single submitter ⚠
- p.Glu49Lys Single submitter ⚠
- p.Gly177Ser Single submitter ⚠
- p.Gly24Glu Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Leu130Trp Single submitter ⚠
- p.Leu235Val Single submitter ⚠
- p.Leu337Val Single submitter ⚠
- p.Lys132Glu Single submitter ⚠
- p.Lys171Gln Single submitter ⚠
- p.Lys184Thr Single submitter ⚠
- p.Lys212Glu Single submitter ⚠
- p.Met315Thr Single submitter ⚠
- p.Met90Val Single submitter ⚠
- p.Pro274Leu Single submitter ⚠
- p.Pro287Leu Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro323Leu Single submitter ⚠
- p.Pro324Arg Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Pro60Thr Single submitter ⚠
- p.Ser128Gly Single submitter ⚠
- p.Ser227Thr Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr291Ile Single submitter ⚠
- p.Tyr185His Single submitter ⚠
- p.Val363Gly Single submitter ⚠
- p.Val88Leu Single submitter ⚠
- p.Tyr275Asp No assertion criteria breast ductal adenocarcinoma ⚠