CREB5 — 59 ClinVar variants
All ClinVar germline CREB5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
59 Uncertain significance
Full CREB5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CREB5 p.Ala193Thr Uncertain significance Single submitter
- CREB5 p.Arg200Gln Uncertain significance Single submitter
- CREB5 p.Arg265Gln Uncertain significance Single submitter
- CREB5 p.Arg366Leu Uncertain significance Single submitter
- CREB5 p.Arg64Lys Uncertain significance Single submitter
- CREB5 p.Arg97Leu Uncertain significance Single submitter
- CREB5 p.Asn477Ser Uncertain significance Single submitter
- CREB5 p.Asp375Gly Uncertain significance Single submitter
- CREB5 p.Gln447Arg Uncertain significance Single submitter
- CREB5 p.Gln472Pro Uncertain significance Single submitter
- CREB5 p.Glu457Gly Uncertain significance Single submitter
- CREB5 p.Glu487Lys Uncertain significance Single submitter
- CREB5 p.Gly113Arg Uncertain significance Single submitter
- CREB5 p.Gly364Trp Uncertain significance Single submitter
- CREB5 p.His257Asp Uncertain significance Single submitter
- CREB5 p.His326Gln Uncertain significance Single submitter
- CREB5 p.His84Asn Uncertain significance Single submitter
- CREB5 p.Leu117Pro Uncertain significance Single submitter
- CREB5 p.Leu122Gln Uncertain significance Single submitter
- CREB5 p.Met228Val Uncertain significance Single submitter
- CREB5 p.Met252Val Uncertain significance Single submitter
- CREB5 p.Met258Val Uncertain significance Single submitter
- CREB5 p.Met262Thr Uncertain significance Single submitter
- CREB5 p.Phe16Leu Uncertain significance Single submitter
- CREB5 p.Phe27Leu Uncertain significance Single submitter
- CREB5 p.Pro286Ser Uncertain significance Single submitter
- CREB5 p.Pro297Gln Uncertain significance Single submitter
- CREB5 p.Ser100Leu Uncertain significance Single submitter
- CREB5 p.Ser422Thr Uncertain significance Single submitter
- CREB5 p.Thr110Met Uncertain significance Single submitter
- CREB5 p.Thr127Ile Uncertain significance Single submitter
- CREB5 p.Thr329Pro Uncertain significance Single submitter
- CREB5 p.Tyr3His Uncertain significance Single submitter
- CREB5 p.Val129Ile Uncertain significance Single submitter
- CREB5 p.Val488Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- CREB5 p.Ala221Asp Uncertain significance Single submitter
- CREB5 p.Arg152Cys Uncertain significance Single submitter
- CREB5 p.Arg26Cys Uncertain significance Single submitter
- CREB5 p.Arg26His Uncertain significance Single submitter
- CREB5 p.Asn124Lys Uncertain significance Single submitter
- CREB5 p.Gln153Lys Uncertain significance Single submitter
- CREB5 p.Gln354Leu Uncertain significance Single submitter
- CREB5 p.Glu77Lys Uncertain significance Single submitter
- CREB5 p.Gly256Val Uncertain significance Single submitter
- CREB5 p.His321Leu Uncertain significance Single submitter
- CREB5 p.Lys432Arg Uncertain significance Single submitter
- CREB5 p.Met262Ile Uncertain significance Single submitter
- CREB5 p.Pro138Leu Uncertain significance Single submitter
- CREB5 p.Pro15Leu Uncertain significance Single submitter
- CREB5 p.Pro223Leu Uncertain significance Single submitter
- CREB5 p.Pro278Leu Uncertain significance Single submitter
- CREB5 p.Pro285Leu Uncertain significance Single submitter
- CREB5 p.Pro297Leu Uncertain significance Single submitter
- CREB5 p.Pro303Thr Uncertain significance Single submitter
- CREB5 p.Ser141Cys Uncertain significance Single submitter
- CREB5 p.Ser486Ile Uncertain significance Single submitter
- CREB5 p.Thr283Ile Uncertain significance Single submitter
- CREB5 p.Val398Phe Uncertain significance Single submitter
- CREB5 p.Val72Met Uncertain significance Single submitter
All CREB5 variants
Uncertain significance 59
- p.Ala193Thr Single submitter ⚠
- p.Ala221Asp Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg26Cys Single submitter ⚠
- p.Arg26His Single submitter ⚠
- p.Arg366Leu Single submitter ⚠
- p.Arg64Lys Single submitter ⚠
- p.Arg97Leu Single submitter ⚠
- p.Asn124Lys Single submitter ⚠
- p.Asn477Ser Single submitter ⚠
- p.Asp375Gly Single submitter ⚠
- p.Gln153Lys Single submitter ⚠
- p.Gln354Leu Single submitter ⚠
- p.Gln447Arg Single submitter ⚠
- p.Gln472Pro Single submitter ⚠
- p.Glu457Gly Single submitter ⚠
- p.Glu487Lys Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Gly113Arg Single submitter ⚠
- p.Gly256Val Single submitter ⚠
- p.Gly364Trp Single submitter ⚠
- p.His257Asp Single submitter ⚠
- p.His321Leu Single submitter ⚠
- p.His326Gln Single submitter ⚠
- p.His84Asn Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu122Gln Single submitter ⚠
- p.Lys432Arg Single submitter ⚠
- p.Met228Val Single submitter ⚠
- p.Met252Val Single submitter ⚠
- p.Met258Val Single submitter ⚠
- p.Met262Ile Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Phe16Leu Single submitter ⚠
- p.Phe27Leu Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro15Leu Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro286Ser Single submitter ⚠
- p.Pro297Gln Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro303Thr Single submitter ⚠
- p.Ser100Leu Single submitter ⚠
- p.Ser141Cys Single submitter ⚠
- p.Ser422Thr Single submitter ⚠
- p.Ser486Ile Single submitter ⚠
- p.Thr110Met Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Thr283Ile Single submitter ⚠
- p.Thr329Pro Single submitter ⚠
- p.Tyr3His Single submitter ⚠
- p.Val129Ile Single submitter ⚠
- p.Val398Phe Single submitter ⚠
- p.Val488Met Single submitter ⚠
- p.Val72Met Single submitter ⚠