CREBZF — 48 ClinVar variants
All ClinVar germline CREBZF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 47 Uncertain significance
Full CREBZF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CREBZF p.Ala182Thr Uncertain significance Single submitter
- CREBZF p.Ala26Thr Uncertain significance Single submitter
- CREBZF p.Ala77Thr Uncertain significance Single submitter
- CREBZF p.Arg186Pro Uncertain significance Single submitter
- CREBZF p.Arg283Gln Uncertain significance Single submitter
- CREBZF p.Arg70Gly Uncertain significance Single submitter
- CREBZF p.Asn168Asp Uncertain significance Single submitter
- CREBZF p.Asn202Lys Uncertain significance Single submitter
- CREBZF p.Gln204Arg Uncertain significance Single submitter
- CREBZF p.Gln313Glu Uncertain significance Single submitter
- CREBZF p.Gln56Arg Uncertain significance Single submitter
- CREBZF p.Glu249Gln Uncertain significance Single submitter
- CREBZF p.Glu43Gly Uncertain significance Single submitter
- CREBZF p.Glu81Gly Uncertain significance Single submitter
- CREBZF p.Gly141Arg Uncertain significance Single submitter
- CREBZF p.Gly41Arg Uncertain significance Single submitter
- CREBZF p.Gly41Val Uncertain significance Single submitter
- CREBZF p.His330Gln Uncertain significance Single submitter
- CREBZF p.His330Pro Uncertain significance Single submitter
- CREBZF p.Leu91Phe Uncertain significance Single submitter
- CREBZF p.Ser189Pro Uncertain significance Single submitter
- CREBZF p.Ser209Gly Uncertain significance Single submitter
- CREBZF p.Thr18Ala Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- CREBZF p.Ala152Thr Uncertain significance Single submitter
- CREBZF p.Ala269Thr Uncertain significance Single submitter
- CREBZF p.Ala39Val Uncertain significance Single submitter
- CREBZF p.Arg346Trp Uncertain significance Single submitter
- CREBZF p.Arg53His Uncertain significance Single submitter
- CREBZF p.Asp117Asn Uncertain significance Single submitter
- CREBZF p.Asp161Ala Uncertain significance Single submitter
- CREBZF p.Asp332Glu Uncertain significance Single submitter
- CREBZF p.Asp98Val Uncertain significance Single submitter
- CREBZF p.Glu42Gln Uncertain significance Single submitter
- CREBZF p.Gly128Arg Uncertain significance Single submitter
- CREBZF p.Gly66Trp Uncertain significance Single submitter
- CREBZF p.Gly71Val Uncertain significance Single submitter
- CREBZF p.Leu102Pro Uncertain significance Single submitter
- CREBZF p.Leu8Arg Uncertain significance Single submitter
- CREBZF p.Leu91Ile Uncertain significance Single submitter
- CREBZF p.Lys208Glu Uncertain significance Single submitter
- CREBZF p.Lys335Asn Uncertain significance Single submitter
- CREBZF p.Pro23Gln Uncertain significance Single submitter
- CREBZF p.Ser125Arg Uncertain significance Single submitter
- CREBZF p.Ser137Leu Uncertain significance Single submitter
- CREBZF p.Ser350Cys Uncertain significance Single submitter
- CREBZF p.Ser79Tyr Uncertain significance Single submitter
- CREBZF p.Val257Ile Uncertain significance Single submitter
All CREBZF variants
Benign 1
- p.Asp121= Single submitter
Uncertain significance 47
- p.Ala152Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala77Thr Single submitter ⚠
- p.Arg186Pro Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg53His Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Asn168Asp Single submitter ⚠
- p.Asn202Lys Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp161Ala Single submitter ⚠
- p.Asp332Glu Single submitter ⚠
- p.Asp98Val Single submitter ⚠
- p.Gln204Arg Single submitter ⚠
- p.Gln313Glu Single submitter ⚠
- p.Gln56Arg Single submitter ⚠
- p.Glu249Gln Single submitter ⚠
- p.Glu42Gln Single submitter ⚠
- p.Glu43Gly Single submitter ⚠
- p.Glu81Gly Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly141Arg Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Gly41Val Single submitter ⚠
- p.Gly66Trp Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.His330Gln Single submitter ⚠
- p.His330Pro Single submitter ⚠
- p.Leu102Pro Single submitter ⚠
- p.Leu8Arg Single submitter ⚠
- p.Leu91Ile Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Lys208Glu Single submitter ⚠
- p.Lys335Asn Single submitter ⚠
- p.Pro23Gln Single submitter ⚠
- p.Ser125Arg Single submitter ⚠
- p.Ser137Leu Single submitter ⚠
- p.Ser189Pro Single submitter ⚠
- p.Ser209Gly Single submitter ⚠
- p.Ser350Cys Single submitter ⚠
- p.Ser79Tyr Single submitter ⚠
- p.Thr18Ala Single submitter ⚠
- p.Val257Ile Single submitter ⚠