CREG1 — 41 ClinVar variants
All ClinVar germline CREG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 39 Uncertain significance
Full CREG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CREG1 p.Ala11Val Uncertain significance Single submitter
- CREG1 p.Ala18Ser Uncertain significance Single submitter
- CREG1 p.Ala23Val Uncertain significance Single submitter
- CREG1 p.Ala56Glu Uncertain significance Single submitter
- CREG1 p.Ala70Ser Uncertain significance Single submitter
- CREG1 p.Ala86Pro Uncertain significance Single submitter
- CREG1 p.Ala9Gly Uncertain significance Single submitter
- CREG1 p.Ala9Pro Uncertain significance Single submitter
- CREG1 p.Arg10Pro Uncertain significance Single submitter
- CREG1 p.Asn216Lys Uncertain significance Single submitter
- CREG1 p.Gly204Asp Uncertain significance Single submitter
- CREG1 p.Gly3Ala Uncertain significance Single submitter
- CREG1 p.His37Gln Uncertain significance Single submitter
- CREG1 p.Ile208Phe Uncertain significance Single submitter
- CREG1 p.Tyr214Asn Uncertain significance Single submitter
- CREG1 p.Val26Ala Uncertain significance Single submitter
- CREG1 p.Val58Leu Uncertain significance Single submitter
- CREG1 p.Val62Glu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CREG1 p.Ala130Ser Uncertain significance Single submitter
- CREG1 p.Ala15Thr Uncertain significance Single submitter
- CREG1 p.Ala29Ser Uncertain significance Single submitter
- CREG1 p.Ala86Val Uncertain significance Single submitter
- CREG1 p.Arg174Gln Uncertain significance Single submitter
- CREG1 p.Arg30Gln Uncertain significance Single submitter
- CREG1 p.Arg35Gln Uncertain significance Single submitter
- CREG1 p.Arg6Cys Uncertain significance Single submitter
- CREG1 p.Arg81Ser Uncertain significance Single submitter
- CREG1 p.Asn216Ile Uncertain significance Single submitter
- CREG1 p.Asp54Tyr Uncertain significance Single submitter
- CREG1 p.Glu119Gly Uncertain significance Single submitter
- CREG1 p.Ile150Met Uncertain significance Single submitter
- CREG1 p.Leu192Phe Uncertain significance Single submitter
- CREG1 p.Lys191Arg Uncertain significance Single submitter
- CREG1 p.Pro103Leu Uncertain significance Single submitter
- CREG1 p.Pro47Leu Uncertain significance Single submitter
- CREG1 p.Ser108Asn Uncertain significance Single submitter
- CREG1 p.Ser44Phe Uncertain significance Single submitter
- CREG1 p.Val88Ala Uncertain significance Single submitter
- CREG1 p.Val88Leu Uncertain significance Single submitter
All CREG1 variants
Likely benign 2
Uncertain significance 39
- p.Ala11Val Single submitter ⚠
- p.Ala130Ser Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala18Ser Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala29Ser Single submitter ⚠
- p.Ala56Glu Single submitter ⚠
- p.Ala70Ser Single submitter ⚠
- p.Ala86Pro Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Ala9Pro Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Arg81Ser Single submitter ⚠
- p.Asn216Ile Single submitter ⚠
- p.Asn216Lys Single submitter ⚠
- p.Asp54Tyr Single submitter ⚠
- p.Glu119Gly Single submitter ⚠
- p.Gly204Asp Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.His37Gln Single submitter ⚠
- p.Ile150Met Single submitter ⚠
- p.Ile208Phe Single submitter ⚠
- p.Leu192Phe Single submitter ⚠
- p.Lys191Arg Single submitter ⚠
- p.Pro103Leu Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Ser108Asn Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Tyr214Asn Single submitter ⚠
- p.Val26Ala Single submitter ⚠
- p.Val58Leu Single submitter ⚠
- p.Val62Glu Single submitter ⚠
- p.Val88Ala Single submitter ⚠
- p.Val88Leu Single submitter ⚠