CRH — 45 ClinVar variants
All ClinVar germline CRH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
3 Benign · 1 Benign/Likely benign · 7 Likely benign · 34 Uncertain significance
Full CRH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRH p.Ala140Gly Uncertain significance Single submitter
- CRH p.Ala37Val Uncertain significance Single submitter
- CRH p.Ala84Val Uncertain significance Single submitter
- CRH p.Arg123Gly Uncertain significance Single submitter
- CRH p.Arg176Lys Uncertain significance Single submitter
- CRH p.Arg28Gly Uncertain significance Single submitter
- CRH p.Arg67His Uncertain significance Single submitter
- CRH p.Asn110Ser Uncertain significance Single submitter
- CRH p.Asn80Ser Uncertain significance Single submitter
- CRH p.Gln36Arg Uncertain significance Single submitter
- CRH p.Gln48Arg Uncertain significance Single submitter
- CRH p.Gln48Lys Uncertain significance Single submitter
- CRH p.Glu146Ala Uncertain significance Single submitter
- CRH p.Glu54Ala Uncertain significance Single submitter
- CRH p.Gly142Ser Uncertain significance Single submitter
- CRH p.Gly29Arg Uncertain significance Single submitter
- CRH p.Gly97Val Uncertain significance Single submitter
- CRH p.Gly99Ser Uncertain significance Single submitter
- CRH p.Leu132Val Uncertain significance Single submitter
- CRH p.Leu141Val Uncertain significance Single submitter
- CRH p.Met68Leu Uncertain significance Single submitter
- CRH p.Pro129Leu Uncertain significance Single submitter
- CRH p.Pro20Thr Uncertain significance Single submitter
- CRH p.Pro43Arg Uncertain significance Single submitter
- CRH p.Pro89His Uncertain significance Single submitter
- CRH p.Ser103Leu Uncertain significance Single submitter
- CRH p.Ser128Arg Uncertain significance Single submitter
- CRH p.Val114Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CRH variants
Benign 3
- p.Gly96= Multiple submitters
- p.Leu17= Multiple submitters
- p.Pro51dup Multiple submitters
Benign/Likely benign 1
- p.Arg152= Multiple submitters
Likely benign 7
Uncertain significance 34
- p.Ala140Gly Single submitter ⚠
- p.Ala177Thr Single submitter
- p.Ala24Thr Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg176Lys Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Gln36Arg Single submitter ⚠
- p.Gln48Arg Single submitter ⚠
- p.Gln48Lys Single submitter ⚠
- p.Gln60_Ala61insSerGluGlnProGlnGlnProGln Single submitter
- p.Glu146Ala Single submitter ⚠
- p.Glu54Ala Single submitter ⚠
- p.Gly142Ser Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly97Val Single submitter ⚠
- p.Gly99Ser Single submitter ⚠
- p.Leu132Val Single submitter ⚠
- p.Leu141Val Single submitter ⚠
- p.Leu66His Single submitter ⚠
- p.Met174Ile Single submitter ⚠
- p.Met68Leu Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro20Thr Single submitter ⚠
- p.Pro43Arg Single submitter ⚠
- p.Pro89His Single submitter ⚠
- p.Ser103Leu Single submitter ⚠
- p.Ser128Arg Single submitter ⚠
- p.Val114Leu Single submitter ⚠