CRHBP — 28 ClinVar variants
All ClinVar germline CRHBP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
2 Benign · 2 Likely benign · 24 Uncertain significance
Full CRHBP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRHBP p.Ala32Thr Uncertain significance Single submitter
- CRHBP p.Arg136Gln Uncertain significance Single submitter
- CRHBP p.Arg59Gln Uncertain significance Single submitter
- CRHBP p.Arg76Leu Uncertain significance Single submitter
- CRHBP p.Asp75Asn Uncertain significance Single submitter
- CRHBP p.Glu238Gln Uncertain significance Single submitter
- CRHBP p.Gly236Ser Uncertain significance Single submitter
- CRHBP p.Gly50Ala Uncertain significance Single submitter
- CRHBP p.His10Asn Uncertain significance Single submitter
- CRHBP p.His10Tyr Uncertain significance Single submitter
- CRHBP p.His80Gln Uncertain significance Single submitter
- CRHBP p.Ile14Val Uncertain significance Single submitter
- CRHBP p.Ile240Met Uncertain significance Single submitter
- CRHBP p.Phe37Val Uncertain significance Single submitter
- CRHBP p.Val225Ile Uncertain significance Single submitter
- CRHBP p.Val285Ile Uncertain significance Single submitter
- CRHBP p.Val294Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CRHBP p.Asn179Ser Uncertain significance Single submitter
- CRHBP p.Asp219His Uncertain significance Single submitter
- CRHBP p.Asp98His Uncertain significance Single submitter
- CRHBP p.Glu305Lys Uncertain significance Single submitter
- CRHBP p.Phe123Ser Uncertain significance Single submitter
- CRHBP p.Pro130Arg Uncertain significance Single submitter
All CRHBP variants
Likely benign 2
- p.His164Arg Single submitter
- p.Thr258Met Single submitter
Uncertain significance 24
- p.Ala32Thr Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg59Gln Single submitter ⚠
- p.Arg76Leu Single submitter ⚠
- p.Asn179Ser Single submitter ⚠
- p.Asp219His Single submitter ⚠
- p.Asp75Asn Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Glu238Gln Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Gly236Ser Single submitter ⚠
- p.Gly50Ala Single submitter ⚠
- p.His10Asn Single submitter ⚠
- p.His10Tyr Single submitter ⚠
- p.His80Gln Single submitter ⚠
- p.Ile14Val Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Phe123Ser Single submitter ⚠
- p.Phe160Ile Single submitter
- p.Phe37Val Single submitter ⚠
- p.Pro130Arg Single submitter ⚠
- p.Val225Ile Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val294Leu Single submitter ⚠