CRHR2 — 75 ClinVar variants
All ClinVar germline CRHR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
2 Benign · 6 Likely benign · 67 Uncertain significance
Full CRHR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRHR2 p.Arg145Leu Uncertain significance Single submitter
- CRHR2 p.Arg148Trp Uncertain significance Single submitter
- CRHR2 p.Arg221His Uncertain significance Single submitter
- CRHR2 p.Asn344Asp Uncertain significance Single submitter
- CRHR2 p.Asp262Asn Uncertain significance Single submitter
- CRHR2 p.Asp262Glu Uncertain significance Single submitter
- CRHR2 p.Cys50Trp Uncertain significance Single submitter
- CRHR2 p.Cys64Phe Uncertain significance Single submitter
- CRHR2 p.Glu175Asp Uncertain significance Single submitter
- CRHR2 p.Glu301Lys Uncertain significance Single submitter
- CRHR2 p.Glu66Ala Uncertain significance Single submitter
- CRHR2 p.Gly261Ser Uncertain significance Single submitter
- CRHR2 p.Gly48Ala Uncertain significance Single submitter
- CRHR2 p.Ile213Thr Uncertain significance Single submitter
- CRHR2 p.Ile244Val Uncertain significance Single submitter
- CRHR2 p.Leu347Pro Uncertain significance Single submitter
- CRHR2 p.Met291Thr Uncertain significance Single submitter
- CRHR2 p.Phe194Ile Uncertain significance Single submitter
- CRHR2 p.Phe361Leu Uncertain significance Single submitter
- CRHR2 p.Pro394Ser Uncertain significance Single submitter
- CRHR2 p.Ser297Phe Uncertain significance Single submitter
- CRHR2 p.Thr157Ile Uncertain significance Single submitter
- CRHR2 p.Trp89Cys Uncertain significance Single submitter
- CRHR2 p.Tyr113His Uncertain significance Single submitter
- CRHR2 p.Tyr193Asn Uncertain significance Single submitter
- CRHR2 p.Tyr37Asn Uncertain significance Single submitter
- CRHR2 p.Val150Met Uncertain significance Single submitter
- CRHR2 p.Val281Leu Uncertain significance Single submitter
- CRHR2 p.Val287Ile Uncertain significance Single submitter
- CRHR2 p.Val355Met Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- CRHR2 p.Arg114Cys Uncertain significance Single submitter
- CRHR2 p.Arg142Trp Uncertain significance Single submitter
- CRHR2 p.Arg145Cys Uncertain significance Single submitter
- CRHR2 p.Arg221Cys Uncertain significance Single submitter
- CRHR2 p.Arg223His Uncertain significance Single submitter
- CRHR2 p.Arg295Cys Uncertain significance Single submitter
- CRHR2 p.Arg367Cys Uncertain significance Single submitter
- CRHR2 p.Arg376Cys Uncertain significance Single submitter
- CRHR2 p.Arg389Gln Uncertain significance Single submitter
- CRHR2 p.Arg399Trp Uncertain significance Single submitter
- CRHR2 p.Arg81Gln Uncertain significance Single submitter
- CRHR2 p.Asn251Lys Uncertain significance Single submitter
- CRHR2 p.Asn329Asp Uncertain significance Single submitter
- CRHR2 p.Asp173Asn Uncertain significance Single submitter
- CRHR2 p.Cys233Tyr Uncertain significance Single submitter
- CRHR2 p.Gln337His Uncertain significance Single submitter
- CRHR2 p.Gln378His Uncertain significance Single submitter
- CRHR2 p.Glu332Lys Uncertain significance Single submitter
- CRHR2 p.Glu66Lys Uncertain significance Single submitter
- CRHR2 p.Lys307Arg Likely benign Single submitter
- CRHR2 p.Met165Ile Uncertain significance Single submitter
- CRHR2 p.Met324Thr Uncertain significance Single submitter
- CRHR2 p.Phe138Leu Uncertain significance Single submitter
- CRHR2 p.Phe326Leu Uncertain significance Single submitter
- CRHR2 p.Pro237Ser Uncertain significance Single submitter
- CRHR2 p.Pro63Arg Uncertain significance Single submitter
- CRHR2 p.Ser218Phe Uncertain significance Single submitter
- CRHR2 p.Ser396Leu Uncertain significance Single submitter
- CRHR2 p.Thr211Met Uncertain significance Single submitter
- CRHR2 p.Thr298Ile Uncertain significance Single submitter
- CRHR2 p.Thr302Ala Uncertain significance Single submitter
- CRHR2 p.Thr408Met Uncertain significance Single submitter
- CRHR2 p.Tyr248Cys Uncertain significance Single submitter
- CRHR2 p.Tyr39Cys Uncertain significance Single submitter
- CRHR2 p.Val195Met Uncertain significance Single submitter
- CRHR2 p.Val328Ile Uncertain significance Single submitter
- CRHR2 p.Val411Met Benign Single submitter
All CRHR2 variants
Benign 2
- p.Ala32= Single submitter
- p.Val411Met Single submitter ⚠
Likely benign 6
- c.832-5T>A Single submitter
- p.Ala410Thr Single submitter
- p.Gly245Ser Single submitter
- p.Ile115Val Single submitter
- p.Ile190Val Single submitter
- p.Lys307Arg Single submitter ⚠
Uncertain significance 67
- p.Arg114Cys Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg145Cys Single submitter ⚠
- p.Arg145Leu Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg221Cys Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg223His Single submitter ⚠
- p.Arg295Cys Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg389Gln Single submitter ⚠
- p.Arg399Trp Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Asn251Lys Single submitter ⚠
- p.Asn329Asp Single submitter ⚠
- p.Asn344Asp Single submitter ⚠
- p.Asp173Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp262Glu Single submitter ⚠
- p.Cys233Tyr Single submitter ⚠
- p.Cys50Trp Single submitter ⚠
- p.Cys64Phe Single submitter ⚠
- p.Gln337His Single submitter ⚠
- p.Gln36His Single submitter
- p.Gln378His Single submitter ⚠
- p.Glu175Asp Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu332Lys Single submitter ⚠
- p.Glu66Ala Single submitter ⚠
- p.Glu66Lys Single submitter ⚠
- p.Gly261Ser Single submitter ⚠
- p.Gly48Ala Single submitter ⚠
- p.Ile213Thr Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Leu347Pro Single submitter ⚠
- p.Met165Ile Single submitter ⚠
- p.Met291Thr Single submitter ⚠
- p.Met324Thr Single submitter ⚠
- p.Phe138Leu Single submitter ⚠
- p.Phe194Ile Single submitter ⚠
- p.Phe326Leu Single submitter ⚠
- p.Phe361Leu Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro394Ser Single submitter ⚠
- p.Pro63Arg Single submitter ⚠
- p.Ser218Phe Single submitter ⚠
- p.Ser297Phe Single submitter ⚠
- p.Ser396Leu Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr211Met Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
- p.Thr302Ala Single submitter ⚠
- p.Thr408Met Single submitter ⚠
- p.Trp89Cys Single submitter ⚠
- p.Tyr113His Single submitter ⚠
- p.Tyr193Asn Single submitter ⚠
- p.Tyr248Cys Single submitter ⚠
- p.Tyr37Asn Single submitter ⚠
- p.Tyr39Cys Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val195Met Single submitter ⚠
- p.Val281Leu Single submitter ⚠
- p.Val287Ile Single submitter ⚠
- p.Val328Ile Single submitter ⚠
- p.Val355Met Single submitter ⚠
- p.Tyr305= No assertion criteria