CRIP1 — 25 ClinVar variants
All ClinVar germline CRIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Benign · 24 Uncertain significance
Full CRIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRIP1 p.Ala58Pro Uncertain significance Single submitter
- CRIP1 p.Arg68Gly Uncertain significance Single submitter
- CRIP1 p.Arg68Pro Uncertain significance Single submitter
- CRIP1 p.Cys28Trp Uncertain significance Single submitter
- CRIP1 p.Cys34Arg Uncertain significance Single submitter
- CRIP1 p.Glu47Gln Uncertain significance Single submitter
- CRIP1 p.Glu47Lys Uncertain significance Single submitter
- CRIP1 p.Glu72Lys Uncertain significance Single submitter
- CRIP1 p.Gly21Cys Uncertain significance Single submitter
- CRIP1 p.Leu38Pro Uncertain significance Single submitter
- CRIP1 p.Lys30Arg Uncertain significance Single submitter
- CRIP1 p.Lys30Glu Uncertain significance Single submitter
- CRIP1 p.Phe66Leu Uncertain significance Single submitter
- CRIP1 p.Phe76Leu Uncertain significance Single submitter
- CRIP1 p.Pro55His Uncertain significance Single submitter
- CRIP1 p.Val11Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CRIP1 p.Arg16Thr Uncertain significance Single submitter
- CRIP1 p.Arg26Gln Uncertain significance Single submitter
- CRIP1 p.Arg26Trp Uncertain significance Single submitter
- CRIP1 p.Arg68Gln Uncertain significance Single submitter
- CRIP1 p.Arg68Trp Uncertain significance Single submitter
- CRIP1 p.Gly42Arg Uncertain significance Single submitter
- CRIP1 p.Pro55Ala Uncertain significance Single submitter
- CRIP1 p.Thr37Met Uncertain significance Single submitter
All CRIP1 variants
Benign 1
- p.Cys52Phe Multiple submitters
Uncertain significance 24
- p.Ala58Pro Single submitter ⚠
- p.Arg16Thr Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg68Pro Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Cys28Trp Single submitter ⚠
- p.Cys34Arg Single submitter ⚠
- p.Glu47Gln Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly21Cys Single submitter ⚠
- p.Gly42Arg Single submitter ⚠
- p.Leu38Pro Single submitter ⚠
- p.Lys30Arg Single submitter ⚠
- p.Lys30Glu Single submitter ⚠
- p.Phe66Leu Single submitter ⚠
- p.Phe76Leu Single submitter ⚠
- p.Pro55Ala Single submitter ⚠
- p.Pro55His Single submitter ⚠
- p.Thr37Met Single submitter ⚠
- p.Val11Leu Single submitter ⚠